2-(2-Amino-5-bromobenzoyl)pyridine

2- (2-Amino-5-bromobenzyl) derivatives are mostly used in the field of medicinal chemistry and are often used as key intermediates in drug synthesis. They are crucial in drug development and can be used to construct compound structures with unique pharmacological activities through specific chemical reactions to help create new drugs.
In organic synthesis, 2- (2-Amino-5-bromobenzyl) derivatives can be used as key building blocks. By reacting with different reagents, diverse chemical transformations can be achieved to generate organic molecules with complex structures and specific functions. Because their structures contain amino and bromobenzyl groups, they can participate in many classical organic reactions, such as nucleophilic substitution, coupling reactions, etc. For example, the amino group can be acylated with acid chloride, acid anhydride, etc. to build an amide structure; the bromine atom in bromobenzyl has high activity and can be replaced by nucleophiles to introduce various functional groups.
In pharmaceutical chemistry, compounds designed and synthesized based on this derivative have been studied to show a variety of biological activities, such as antibacterial, anti-inflammatory, and anti-tumor. Researchers use its structural characteristics to modify and optimize the pharmacokinetic properties and efficacy of drugs to meet the needs of clinical treatment.

2 - (2-hydroxy-5-bromobenzyl) has the following physical properties:
The appearance of this compound is mostly white to light yellow crystalline powder, which is a common appearance of many organic compounds. The powder-like substance is conducive to its dispersion in subsequent reactions and dissolution in different solvents.
In terms of solubility, it is slightly soluble in water. This is because although the compound contains hydroxyl groups, which are hydrophilic groups and can form hydrogen bonds with water molecules, the bromine atoms and benzyl groups that coexist in the molecule have greater hydrophobicity, so that the interaction force between the whole molecule and the water molecule is relatively weak, resulting in its limited solubility in water. In organic solvents such as ethanol and dichloromethane, it has good solubility. Hydroxyl groups in ethanol can form hydrogen bonds to interact with hydroxyl groups in compounds. The polarity of organic solvents such as dichloromethane is similar to the polarity of the compound molecule. According to the principle of similar miscibility, it has good solubility in these organic solvents.
The substance has a certain melting point. Generally speaking, the melting point is in a specific temperature range. This melting point characteristic plays a key role in its synthesis, purification and identification process. By measuring the melting point, the purity of the substance can be preliminarily determined. If the deviation between the melting point and the theoretical value is small, it means that the purity of the substance is high; if the deviation is large, it may contain impurities. < Br >
Its density also has a specific value. Density, as one of the basic physical properties of substances, is of great significance in industrial production and laboratory operations to determine the amount of substances, storage methods, and distribution in different phases.
In addition, the compound may have a certain odor, but the odor is usually weak, not a pungent and unpleasant odor. This odor characteristic also helps to identify and judge it preliminarily during operation.

To prepare 2 - (2-hydroxy-5-bromobenzyl) benzoic acid, the chemical synthesis method is as follows:
The starting material is selected to be bromotoluene, and it is first substituted with bromine under light conditions. In this reaction, light provides energy to promote the generation of bromine free radicals, which attack the hydrogen atom on p-bromotoluene methyl to generate p-bromobenzyl bromide. This step requires precise control of the light intensity and reaction time to ensure the purity and yield of the product.
After obtaining p-bromobenzyl bromide, it is reacted with magnesium chips in anhydrous ethyl ether to form Grignard reagent. This process must ensure that the reaction system is anhydrous, because water will react violently with Grignard's reagent and cause it to fail. Grignard's reagent is very active and can react with many compounds containing active hydrogen or carbonyl groups.
At the same time, methyl o-hydroxybenzoate is used as a raw material, and carboxyl methyl is esterified under appropriate reaction conditions. The methylation reaction is usually achieved by co-heating with methanol using sulfuric acid as a catalyst. This step is designed to protect the carboxyl group and avoid its unprovoked participation in subsequent reactions, which will affect the formation of the target product.
Then, the prepared Grignard reagent reacts with methyl o-hydroxybenzoate. The negatively charged carbon in the Grignard reagent attacks the carbonyl carbon of methyl o-hydroxybenzoate and undergoes a nucleophilic addition reaction to generate the corresponding alcohol magnesium salt. This reaction requires strict requirements on the reaction temperature and reagent ratio, and must be carefully regulated.
Finally, the obtained product is hydrolyzed and acidified. Hydrolysis converts the alcohol magnesium salt into alcohol, and acidification converts the carboxylate into carboxyl groups, and finally obtains 2 - (2-hydroxy-5-bromobenzyl) benzoic acid. The hydrolysis and acidification process requires controlling the reaction conditions, such as pH, temperature, etc., to obtain a high-purity target product.
Although the steps of the above synthesis method are complicated, the required 2- (2-hydroxy-5-bromobenzyl) benzoic acid can be obtained through fine operation and condition control.

The price range of 2- (2-amino-5-bromobenzoyl) in the market is difficult to determine. The price of these chemicals often varies due to multiple factors.
First, the difficulty of preparation has a great impact. If its synthesis requires cumbersome steps, rare raw materials or harsh conditions, the cost will be high and the price will rise accordingly. If many require precise operation and special reagents, the price will be high.
Second, the market supply and demand situation is also critical. If at a certain time, many pharmaceutical companies and scientific research institutions have strong demand for this substance, but the supply is limited, the price will rise; conversely, if the supply exceeds the demand, the price may drop.
Third, the difference in quality grade leads to different prices. Those with high purity and few impurities are mostly used for high-end scientific research and pharmaceutical production, and the price is high; those with ordinary purity are used for general experimental or industrial purposes, and the price is slightly lower.
Fourth, suppliers are related to the scale of transactions. Large-scale purchases, due to large quantities, suppliers may give discounts; scattered small purchases, unit price or higher. And different suppliers have different pricing due to different cost and profit strategies.
In summary, the price of 2 - (2-amino-5-bromobenzoyl) fluctuates unpredictably. To know the exact price, it is necessary to consult chemical raw material suppliers and reagent sellers in detail, combined with real-time market conditions, to obtain a more accurate number.

"Tiangong Kaiwu" is a scientific and technological masterpiece written by Song Yingxing in the Ming Dynasty. Although the book does not directly mention the specific chemical structure of "2- (2-hydroxy-5-chlorobenzyl) ", the related production fields can be explored from similar records.
In the field of chemical raw material preparation, the book describes the preparation of many raw materials. For example, the firing of sulfur is refined by processes such as roasting of sulfur ores. Although the structure of "2- (2-hydroxy-5-chlorobenzyl) " is complex, its preparation or involves similar chemical transformation, such as halogenation, hydroxylation and other steps, which are similar to the transformation ideas of some substances in "Tiangong Kaiwu".
In the field of organic synthesis, although there was no modern concept of organic synthesis in ancient times, there were many examples involving the treatment of organic matter. For example, the winemaking process, the fermentation of grains into wine, involves a series of organic reactions. "2- (2-hydroxy-5-chlorobenzyl) " synthesis requires multiple steps of organic reaction, similar to the control of reaction conditions in ancient winemaking. Factors such as temperature, time, and the proportion of raw materials have a great impact on the synthesis products.
As for related manufacturers, there were naturally no manufacturers in the era of "Tiangong Kaiwu" that corresponded to modern significance. But there were many manual workshops at that time, such as paper workshops and ceramic workshops. For example, in today's world, the production of "2- (2-hydroxy-5-chlorobenzyl) " requires professional chemical enterprises, equipped with advanced equipment and technical personnel, and following strict safety and environmental protection standards. Although the form is different from that of ancient workshops, the pursuit of product quality and production efficiency is consistent.