2-(2,4-diflurophenyl)pyridine

The main use of (2,4-diethylamino) phenol, in the genus Tiangong Kaiwu, is mostly used in chemical dyeing and pharmaceutical synthesis.
In chemical dyeing, this substance is often an important raw material for dye synthesis. Because of its special chemical structure, it can undergo a series of chemical reactions to produce dyes with bright colors and good fastness. Although the ancients did not know its precise chemical principle, they learned through practice that based on this, many wonderful colors can be obtained, which can be used for fabric dyeing to make clothing, fabrics and other colors rich to meet the needs of different classes and occasions. For example, in silk dyeing, it can dye colorful patterns, enhance the beauty and value of silk, and contribute to the development of the silk industry at that time.
In the field of pharmaceutical synthesis, (2,4-diethylamino) phenol also plays an important role. Although ancient physicians did not know the mechanism of action at the molecular level, they accumulated experience and knew that it could participate in the preparation of some drugs. Or because of its certain pharmacological activity, it can be processed and compatible to relieve some diseases. For example, it can assist in the preparation of drugs such as clearing heat, detoxification, and pain relief, which relieved the suffering of patients at that time.
(2,4-diethylamino) phenol played an important role in ancient chemical dyeing and pharmaceutical synthesis, and made great contributions to the production, life and medical care at that time.

There are several common methods for synthesizing 2 - (2,4 - diethylamino) acetaldehyde:
One is to use 2,4 - diethylamino ethanol as the starting material, and the target product can be obtained by oxidation reaction. Suitable oxidizing agents, such as chromium trioxide-pyridine complex (Collins reagent), can be selected. This reagent is mild in oxidation and can oxidize alcohol hydroxyl groups to aldehyde groups under relatively mild reaction conditions. The specific operation is to dissolve 2,4 - diethylamino ethanol in a suitable organic solvent, such as dichloromethane, and slowly add Collins reagent under low temperature stirring. The reaction process needs to be closely monitored during the reaction process, which can be tracked by thin layer chromatography (TLC). After the reaction is completed, regular separation and purification steps, such as extraction, washing, drying, distillation, etc., can obtain pure 2- (2,4-diethylamino) acetaldehyde.
The second is to use 2,4-diethylamino acetonitrile as raw material to achieve the goal through hydrolysis reaction. Under acidic or alkaline conditions, acetonitrile can be hydrolyzed. If acidic conditions are used, dilute sulfuric acid or hydrochloric acid are generally used as hydrolysis reagents. Mix 2,4-diethylamino acetonitrile with an appropriate amount of acid solution, heat and reflux to promote the gradual hydrolysis of acetonitrile into amide, and then hydrolyzed into carboxylic acid. Finally, under controlled reaction conditions, part of the carboxylic acid can be decarboxylated to form an aldehyde. After the reaction is completed, the product is obtained through neutralization, separation, purification and If alkaline conditions are used, such as sodium hydroxide solution, the hydrolysis process is similar, but the subsequent treatment is different, and it needs to be acidified before separation and purification.
The third can be prepared by Grignard reagent reaction. First, halogenated ethane is reacted with magnesium to form ethyl Grignard reagent, and then it is added with 2,4-diethylamino formaldehyde. After the reaction is completed, 2 - (2,4-diethylamino) acetaldehyde can be obtained by hydrolysis. This method needs to be carried out under strict conditions without water and oxygen to ensure the activity and stability of Grignard reagent. The solvent used for the reaction is usually anhydrous ether or tetrahydrofuran. After the addition reaction is completed, a dilute acid solution is slowly added for hydrolysis, and then a series of post-treatment operations are performed to obtain the product.

2 - (2,4 -diethylamino) phenol is an organic compound with multiple physical and chemical properties.
Looking at its physical properties, it is mostly white to light gray crystalline powder under normal conditions, which is easy to store and use. Its melting point is in a specific range, about 126-128 ° C, and the melting point is fixed, which is an important indicator for the identification of this substance. It has limited solubility in water, but it is soluble in organic solvents such as ethanol and ether. This solubility is related to the molecular structure. Because its molecules contain organophilic groups, it has good solubility in organic solvents and poor solubility in water.
In terms of its chemical properties, 2- (2,4-diethylamino) phenol has a certain acidity due to its phenolic hydroxyl group, which can react with bases to form corresponding phenolic salts. Phenolic hydroxyl groups are also easily oxidized. If left in the air for a long time or in contact with strong oxidants, oxidation reactions will occur, resulting in color changes, from white to brown or even darker color. This oxidation characteristic requires strict storage conditions and needs to be sealed and stored to prevent oxidative deterioration. In addition, its amino groups can participate in a variety of reactions, such as salt-forming reactions with acids, acylation reactions with acyl halides, acid anhydrides, etc. These reactions provide the possibility for the synthesis of more complex organic compounds and are widely used in the field of organic synthesis. Due to the fact that its structure contains both phenolic hydroxyl and amino groups, the two functional groups interact with each other, making the substance unique in chemical reactivity. It can be used as an important intermediate in organic synthesis to prepare fine chemicals such as drugs and dyes through a series of reactions.

What is the price of (ditetraethylamino) phenol in the market? Although "Tiangong Kaiwu" does not directly state this, it can be inferred according to the common sense and industry conditions of the materials it describes.
The price of ancient materials often depends on many factors. The first is the difficulty of obtaining raw materials. If the raw material for making (ditetraethylamino) phenol is difficult to pick, or the origin is scarce, the price will be high. As mentioned in the book, some rare minerals are expensive because they are not easy to collect.
The second is the simplicity of the production process. Suppose that the production of this phenol requires complicated processes, multiple refining and synthesis, and precise control of the temperature and time, similar to the fine brewing and smelting processes described in the book, it will consume a lot of labor and material resources, and the price should not be low.
Furthermore, market supply and demand are also the main reasons. If this phenol is needed by many industries at that time, such as dyeing and weaving, medicine, etc., there are many people who want it, but the output is limited, and the price will rise; on the contrary, if the demand is low, the price may decrease.
Regional differences also have an impact. In places where the raw materials are produced or the production skills are exquisite, the price may be slightly lower than elsewhere because they are close to the source and the cost is slightly lower; and in remote places, the price may increase due to transportation costs.
In summary, although it is difficult to determine the exact price of (di, tetraethylamino) phenol in the ancient market, according to the story of "Tiangong Kaiwu", it can be known that its price must be influenced by factors such as raw materials, technology, supply and demand, and geography, or varies from time to time.

2 - (2,4 -diethylamino) phenol, this compound is widely used in many fields.
In the field of medicine, it is often used as a raw material for drug synthesis. Due to its special chemical structure, it can participate in the construction of many drug molecules. For example, some antipyretic and analgesic drugs, with the help of their structural properties, react with other chemical substances to make drugs with specific curative effects and pharmacological activities, which play a key role in relieving human pain and reducing fever symptoms.
In the dye industry, it is an important dye intermediate. Through a series of chemical reactions, it can be converted into various colorful and stable dyes. Like in textile printing and dyeing, the dyes synthesized from this can make the fabric appear rich in color, and have good washing fastness and light fastness, ensuring that the fabric maintains a bright color for a long time.
In the field of cosmetics, there is also a place. Some sunscreen products use their UV absorption properties. After adding this substance, it can improve the sunscreen effect, help protect the skin from UV damage, prevent sunburn, tanning and photoaging.
In organic synthesis chemistry, it is an extremely useful chemical agent. As a reaction substrate or intermediate, it participates in various organic reactions, helps to synthesize organic compounds with complex structures and special functions, and promotes the development and innovation of organic synthesis chemistry.
To sum up, 2- (2,4-diethylamino) phenol plays an important role in the fields of medicine, dyes, cosmetics, and organic synthesis, and is of great significance to the development of these industries.