2-[(2,3-dimethylphenyl)amino]pyridine-3-carboxylic acid

What are the main uses of 2-% 5B% 282% 2C3 + -dimethylbenzyl% 29 hydroxy% 5D alkyl-3-carboxylic acids? This question involves the use of chemical substances. Although "Tiangong Kaiwu" is a masterpiece of ancient science and technology, it covers many process technologies, but the book rarely involves the description of the use of such specific chemical substances.
Because "Tiangong Kaiwu" was written in the Ming Dynasty, at that time, the chemical discipline had not yet developed as systematically as it is today, and it was difficult to accurately explain the uses of such organic chemical structures. The book focuses on agricultural and handicraft production technologies, such as grain processing, silk and hemp textiles, salt making, pottery making, smelting, boat and truck manufacturing, and other fields. Through detailed records of the production processes, tool use, and material selection of these industries, it shows the advanced level of China's industrial and agricultural production at that time.
And for 2-% 5B% 282% 2C3 + -dimethylbenzyl% 29 hydroxy% 5D alkyl-3-carboxylic acids, which are named by modern organic chemistry, their uses need to be explored from the fields of modern chemistry and chemical industry. In modern times, such organic compounds may be used in the field of pharmaceutical synthesis as key intermediates for specific drug molecules, participating in the construction of pharmaceutical active ingredients; they may also be used in materials science to synthesize polymer materials with special properties, such as materials with specific solubility, stability or optical properties; and they may also play an important role in the preparation of fine chemical products, such as some high-end fragrances and special surfactants. In short, to clarify its use, it is necessary to rely on modern chemical research results and materials, which cannot be described in detail in Tiangong Kaiwu.

"Tiangong Kaiwu" says: "The principle of all things has its own origin. The physical properties of Ximing 2- [ (2,3-dimethylbenzyl) amino] ethyl-3-carboxylic acid need to be investigated in detail."
Among this compound, there are many physical properties. Looking at its appearance, it is often in a specific state, either a crystalline solid or a viscous liquid, which varies depending on the surrounding environmental conditions. Its color is also different, either colorless and transparent, or slightly yellowish, which are all characteristics of its physical properties.
When it comes to the melting point, this is the key physical property. The melting point is the temperature at which a substance changes from a solid state to a liquid state. For 2 - [ (2,3 - dimethylbenzyl) amino] ethyl - 3 - carboxylic acids, the melting point reflects the strength of the intermolecular forces. When the temperature rises to the melting point, the molecules gain enough energy to overcome the attractive forces between each other, thereby changing the state of matter. The boiling point is the temperature at which a substance changes from liquid to gaseous state under a specific pressure. Knowing its melting boiling point is crucial in practical operations such as separation and purification.
Solubility cannot be ignored either. This compound exhibits different solubility in different solvents. In polar solvents such as water and alcohols, its solubility may be good or bad, depending on the interaction between the molecular structure and the solvent molecules. If the molecular structure contains polar groups and interacts with the molecules of polar solvents to form hydrogen bonds, etc., it is easily soluble in such solvents; conversely, in non-polar solvents, such as hydrocarbons, the solubility may be different.
In addition, density is also one of its physical properties. Density reflects the mass of a unit volume of matter, and this property is related to the degree of molecular packing of the compound. A tightly packed molecular structure often corresponds to a higher density; otherwise, the density is lower. By measuring the density, it can assist in the identification of the compound and also help to calculate its dosage in practical applications.
The refractive index reflects the ratio of the propagation speed of light in the compound to the propagation speed in vacuum. The refractive index varies depending on the molecular structure of the compound and is an important physical constant for identifying the compound. In optically related applications, accurate determination of refractive index is indispensable.
The physical properties of this 2- [ (2,3-dimethylbenzyl) amino] ethyl-3-carboxylic acid are of great significance in many fields such as chemical industry and medicine, which is related to its application efficiency and prospects.

To prepare 2 - [ (2,3 - dimethylbenzyl) oxy] - 3 - pyridinecarboxylic acid, the synthesis method is as follows:
First, 2,3 - dimethylbenzyl alcohol and suitable halogenated pyridinecarboxylate as starting materials. Take an appropriate amount of 2,3 - dimethylbenzyl alcohol, place it in a clean reactor, add an appropriate amount of basic catalyst, such as potassium carbonate, etc., to enhance the nucleophilicity of the alcohol hydroxyl group. Then slowly add halogenated pyridinecarboxylate, such as methyl chloropyridinecarboxylate, this process needs to control the reaction temperature in a moderate range, about 40 - 60 degrees Celsius, to ensure the smooth progress of the reaction. In the reaction, the alkaline catalyst prompts the oxygen atom of 2,3-dimethylbenzyl alcohol to attack the carbon atom attached to the halogen atom of halogenated pyridinecarboxylate, and a nucleophilic substitution reaction occurs to generate the corresponding ether ester intermediate.
After the reaction is completed, the reaction mixture is processed. The organic phase is extracted with an organic solvent such as ethyl acetate, the organic phase is separated, and an appropriate amount of dilute acid such as dilute hydrochloric acid is washed to remove the remaining alkaline substances, and then washed with saturated saline water to reduce the moisture content in the organic phase. After that, the organic phase is dried with a desiccant such as anhydrous sodium sulfate, the desiccant is filtered off, and the filtrate is distilled under reduced pressure to steam the organic solvent to obtain the ether ester intermediate.
Next, the resulting ether ester intermediate is hydrolyzed. The intermediate is placed in another reactor, an appropriate amount of aqueous sodium hydroxide is added, and the temperature is raised to about 80-90 degrees Celsius to hydrolyze the ester group and convert it to a carboxyl group. After the reaction is completed, the reaction solution is cooled, slowly acidified with dilute hydrochloric acid, and the pH is adjusted to the acidic range. At this time, 2 - [ (2,3-dimethylbenzyl) oxy] -3 -pyridinecarboxylic acid is precipitated in solid form. The precipitated solids are filtered and washed, washed with cold deionized water for several times to remove impurities, and finally dried to obtain the target product 2 - [ (2,3 - dimethylbenzyl) oxy] -3 -pyridinecarboxylic acid.
In addition, other raw material combinations can also be synthesized. If 2,3 - dimethylbenzoic acid is used as the starting material, it is converted into the corresponding acyl chloride through a series of reactions, and then reacted with the alcohol compound containing the pyridine ring under suitable conditions. Subsequent modification is also expected to obtain the target product. This process requires fine control of the reaction conditions and the reaction process of each step.

Looking at what you are asking, it seems to be a matter of prices in the commercial market. What I want to say today is the price of two things, one is "2 - [ (2,3 - dimethylaminoethyl) ether] hydrochloride", and the other is "3 - carboxyphenylboronic acid".
However, in the world of "Tiangong Kaiwu", these chemical substances were not known to people at that time, and there were no such fine chemical substances at that time, so it is difficult to say their prices in the market directly according to the ancient method. Today, unlike in the past, these chemical substances are more common in the fields of chemical industry and scientific research, and their prices often vary greatly due to quality, purity, and supply and demand.
"2 - [ (2,3 - dimethylaminoethyl) ether] hydrochloride", if its purity is very high, suitable for high-end scientific research experiments, its price may be high, up to tens or even hundreds of gold per gram; if it is for industrial use, the purity is slightly lower, the price may be reduced, but it also varies according to the quantity and market supply and demand.
As for "3-carboxyphenylboronic acid", the same is true. Scientific research-grade high purity is required by scientific research institutes and pharmaceutical companies, and its price is not expensive; for industrial use, due to the slightly lower purity requirements, the price may be relatively easy. However, in order to determine its market price, it is necessary to visit chemical raw material firms and chemical trading platforms, and consult recent quotations in detail to obtain accurate figures.

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