2-(1H-Pyrazol-1-yl)pyridine

2-% (1H-imidazole-1-yl) imidazole, its main uses are as follows:
In the field of medicine, it has shown important value. The synthesis of many drugs often uses 2- (1H-imidazole-1-yl) imidazole as the key intermediate. Because of its unique chemical structure and activity, it can skillfully combine with other compounds through a series of chemical reactions to construct drug molecules with specific pharmacological activities. For example, in the synthesis of some drugs used to treat cardiovascular diseases, 2- (1H-imidazole-1-yl) imidazole participates in the reaction, which plays a key role in shaping the structure and function of the drug, helping to improve the affinity and selectivity of the drug to specific targets, thereby enhancing the efficacy and reducing side effects.
It also makes significant contributions in the field of materials science. As a functional organic compound, it can be used to prepare polymer materials with special properties. For example, when preparing some polymer materials with excellent electrical conductivity, the introduction of 2- (1H-imidazole-1-yl) imidazole into the main chain or side chain of the polymer can change the electron cloud distribution of the material and the interaction between molecules, giving the material unique electrical properties. At the same time, in the preparation of adsorption materials, the imidazole group in its structure can coordinate or hydrogen bond with specific ions or molecules to enhance the adsorption capacity of the material to the target substance, which is used in water purification, gas separation and other fields.
In the field of catalysis, 2- (1H-imidazole-1-yl) imidazole can also play a role. It can be used as a ligand to form complexes with metal ions, and then participate in various chemical reactions as an efficient catalyst. For example, in some organic synthesis reactions, the complex catalyst can effectively reduce the activation energy of the reaction, speed up the reaction rate, improve the selectivity of the reaction, make the reaction proceed efficiently in the direction of the desired product, and exhibit good stability and reusability during the reaction process, reducing production costs.

(2- (1H-pyrazole-1-yl) pyridine) has the following physical properties:
The appearance of this compound is often white to light yellow crystalline powder. From the perspective of melting point, it generally has a relatively clear melting point range, which is one of the important physical indicators for identifying the compound. By accurately measuring the melting point, its purity and authenticity can be preliminarily judged.
In terms of solubility, in some common organic solvents such as ethanol and dichloromethane, there is often a certain solubility. In ethanol, with the increase of temperature, its solubility will increase, which can be better dispersed; in dichloromethane, it can also achieve a certain degree of dissolution, which is convenient for uniform dispersion in the organic synthesis reaction system and participation in various reactions.
The compound also has a certain density, a physical property that is crucial in chemical production and quality control, helping to determine the amount of reactant and the ratio of the reaction system.
Its refractive index also has a specific value, and the refractive index can be used to detect the purity of the substance and identify the compound. When light passes through the substance, it will produce a specific refractive phenomenon according to its own structure and molecular arrangement, so as to obtain the corresponding refractive index data. In addition, its chemical properties are relatively stable at room temperature and pressure, but under special conditions such as high temperature, strong acid, and strong base, structural changes may occur or chemical reactions may occur. When storing and using, appropriate conditions should be selected according to these physical properties to ensure that its quality and performance are not affected.

To prepare 2- (1H-pyrazole-1-yl) pyridine, the method is as follows:
First take the pyridine derivative, and introduce the active group at a specific position with appropriate reagents and conditions. This step requires fine control of the temperature, time and reagent dosage of the reaction. The introduced active group should be used to facilitate subsequent connection with the pyrazole.
Then, 1H-pyrazole is prepared. It is often obtained from the corresponding raw materials through cyclization. This cyclization reaction also requires the selection of a suitable catalyst and reaction environment to ensure the purity and yield of the pyrazole product.
When both the pyridine derivative and 1H-pyrazole are ready, the connection reaction between the two is carried out. Coupling reagents can be selected to connect the active position of the pyridine to the specific check point of the pyrazole under mild reaction conditions. In this process, the choice of solvent is also crucial, and its effect on the solubility of the reactants and products and the reaction process must be considered.
After the reaction is completed, the by-products and unreacted raw materials are removed by separation and purification. Column chromatography and recrystallization are commonly used to obtain high-purity 2- (1H-pyrazole-1-yl) pyridine. Throughout the synthesis process, each step of the reaction requires rigorous operation and precise control of the reaction conditions in order to effectively improve the quality and yield of the product.

2-%281H-%E5%90%A1%E5%94%91-1-%E5%9F%BA%29%E5%90%A1 is 2- (1H-pyrazole-1-yl) pyridine, which is an organic compound. In terms of the market, its price range is affected by multiple factors.
First, the purity has a significant impact on the price. If the purity is quite high, it almost reaches the standard used in high-end scientific research or pharmaceutical fields, such as more than 99% purity, the price is often high. Because the preparation of high-purity compounds requires more sophisticated and complex purification processes, the cost will increase significantly. Usually, the price of such high-purity 2- (1H-pyrazole-1-yl) pyridine varies from hundreds to thousands of yuan per gram.
Second, the market supply and demand relationship is also a key factor. If a certain period of time, pharmaceutical companies or scientific research institutions have strong demand for it, but the supply is relatively scarce, the price will rise. On the contrary, if the market supply is sufficient and the demand is flat, the price will fall.
Third, the production scale is closely related to the cost. In large-scale production, due to the scale effect, the unit production cost may be reduced, and the price will be more affordable. In small-scale production, the unit cost is higher, and the price is naturally higher.
Fourth, different sales channels and regions have different prices. Professional chemical reagent suppliers may have relatively high prices due to factors such as brand, service and quality control. In some emerging markets or competitive areas, in order to seize share, the price may be more competitive.
Overall, the price of 2- (1H-pyrazole-1-yl) pyridine of ordinary purity (such as about 95%) may be around tens to hundreds of yuan per gram; for high purity, hundreds to thousands of yuan per gram are possible. The actual price also depends on the specific market conditions and the negotiation between buyers and sellers.

2-%281H-%E5%90%A1%E5%94%91-1-%E5%9F%BA%29%E5%90%A1 is 2- (1H-pyrazole-1-yl) pyridine. The relevant safety precautions for this substance are as follows:
###Toxicity
This substance may be toxic to a certain extent, in the body or interfere with normal physiological functions. The ancients said: "Those who are poisonous are also things that hurt the right." Excessive contact or intake may cause damage to the body. If ingested orally, or irritate the digestive system, cause abdominal pain and vomiting; if absorbed through the skin, or cause skin redness, swelling and itching. For example, the Compendium of Materia Medica says that all kinds of poisons are harmful to the human body, which should not be underestimated.
##Explosion risk
Most of them are organic compounds, which may be flammable under some conditions. "If you can use it well, it will be a blessing, but if you don't use it well, it will be a curse." In case of open fire, hot topic, or cause combustion. And when burning, toxic fumes, such as nitrogen oxides, are released, which are very harmful. Remember the ancient fires. If you use fire carelessly, it will cause life to burn. This thing is flammable and must be cautious.
###Storage Note
It needs to be stored in a cool and ventilated place. "The way to hide things, you must choose a suitable place." Keep away from fire and heat sources to prevent them from reacting when the temperature is too high. And it should be stored separately from oxidants, acids, etc. Because of its active chemical properties, it can mix with other substances, or react violently. If it is not stored properly, such as the accident caused by the mixing of materials recorded in "Tiangong Kaiwu", it should also be taken as a warning.
##Operate protective
Wear protective gloves and goggles when operating. "If you want to do something good, you must first use your tools. Protective equipment, so you can protect yourself." Avoid contact with skin and eyes. If you accidentally come into contact, rinse with plenty of water as soon as possible and seek medical treatment. The operating site also needs to have good ventilation equipment to discharge volatile gases in time to keep the air fresh and prevent the risk of poisoning.