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What is the chemical structure of 2- (1H-Imidazol-1-yl) -4-pyridinecarboxamide
2-%281H-Imidazol-1-yl%29-4-pyridinecarboxamide, in ancient Chinese, this is the expression of an organic compound. Its chemical structure can be analyzed as follows:
Look at its name, this compound contains the core of pyridine (pyridine). Pyridine has a six-membered aromatic ring, which contains a nitrogen atom. At the fourth position of the pyridine ring, there is a carboxamide group (carboxamide), which is formed by connecting a carbonyl group (C = O) with an amino group (-NH2O). It is a common group in organic chemistry and often has certain polarity and reactivity.
After further inspection, in the second position of the pyridine ring, there is 1H-Imidazol-1-yl (1H-Imidazol-1-yl). Imidazole is a five-membered nitrogen-containing aromatic heterocycle with two nitrogen atoms. Among them, 1H-imidazol-1-yl, the group formed by removing the hydrogen at the first position on the imidazole ring, is connected to the pyridine ring through this check point.
The chemical structure of this compound is endowed with unique physical and chemical properties due to the combination of pyridine ring, carboxamide group and imidazole group. Its aromatic ring structure endows certain stability and conjugation effect, carboxylamide group can participate in hydrogen bond formation and other reactions, imidazole group also has a variety of reactive activity check points, which can make this compound in organic synthesis, medicinal chemistry and other fields show unique properties and potential applications.
What are the main uses of 2- (1H-Imidazol-1-yl) -4-pyridinecarboxamide
2-% (1H-imidazole-1-yl) -4-pyridinecarbonamide has a wide range of uses. In the field of medicine, it is often used as a key intermediate for drug development. Due to its unique chemical structure, it can be combined with specific targets in organisms or participate in the regulation of various biochemical reactions in organisms, thus laying the foundation for the creation of new drugs for the treatment of specific diseases.
In the field of scientific research, this compound can be used to study cell signaling pathways. By observing its impact on cell physiological functions and metabolic processes, scientists can gain in-depth insight into the internal working mechanism of cells, explore the root cause of diseases, and provide theoretical support for disease prevention strategies.
In the field of materials science, it also shows potential application value. Or because of its special electronic properties and molecular interaction ability, it can be used to prepare new functional materials, such as materials with special optical and electrical properties, injecting new vitality into the development of materials science.
In the field of pesticides, 2-% (1H-imidazole-1-yl) -4-picolinecarbonamide may provide new ideas for the creation of new pesticides. Use its impact on specific biological activities to develop high-efficiency, low-toxicity and environmentally friendly pesticides to help sustainable agricultural development.
What is the synthesis method of 2- (1H-Imidazol-1-yl) -4-pyridinecarboxamide
To prepare 2- (1H-imidazole-1-yl) -4-pyridinecarbonamide, the method is as follows:
Take the pyridine as the group first, and introduce the carboxyl group into the 4-position of the pyridine in a suitable reaction vessel under specific conditions. The carboxyl group can be obtained from the 4-position of the pyridine through acylation reaction and other pathways to form 4-pyridinecarboxylic acid. This step requires controlling the reaction temperature, duration and proportion of reactants to determine the yield and purity.
Next, 1H-imidazole is introduced into 4-pyridinecarboxylic acid. This process may require the selection of suitable catalysts and solvents to promote the combination of the two. The 1-position of imidazole can be connected to the 2-position of pyridine by means of coupling reaction. The catalyst used should be carefully selected according to the reaction mechanism and conditions, and the solvent should also be considered to affect the solubility and reactivity of the reactants and products.
After the reaction is completed, it needs to go through the steps of separation and purification. High purity 2- (1H-imidazole-1-yl) -4-pyridineformamide can be obtained by recrystallization, column chromatography, etc. During recrystallization, select the appropriate solvent and temperature to precipitate the product and leave impurities in the solution; column chromatography achieves the purpose of separation according to the polarity difference of the substance.
The whole process of preparation requires strict measurement of the reaction process and conditions to ensure the smooth reaction of each step, in order to achieve high yield and high quality products.
What are the physical and chemical properties of 2- (1H-Imidazol-1-yl) -4-pyridinecarboxamide
2- (1H-imidazole-1-yl) -4-pyridineformamide, this is an organic compound. Its physical and chemical properties are unique, let me explain in detail for you.
Looking at its properties, under room temperature and pressure, it is mostly white to white crystalline powder. This form is easy to store and handle, and has shown good operability in many chemical experiments and industrial production processes.
When it comes to solubility, the compound has good solubility in organic solvents such as dimethyl sulfoxide (DMSO), N, N-dimethylformamide (DMF). This property makes it convenient for it to act as a reactant or intermediate in organic synthesis reactions. Because it can be uniformly dispersed in the solvent, the reaction is easier to carry out and the reaction efficiency is improved. However, its solubility in water is relatively limited, but this does not prevent it from functioning in a specific system.
Melting point is one of the important physical properties of the compound to consider. After experimental determination, its melting point is in a specific temperature range, which is of great significance for the purity identification of the compound. If the melting point is accurate and the melting range is narrow, it can be preliminarily inferred that the purity of the compound is quite high; conversely, if the melting point deviates from the expected and the melting range is wide, it implies that it may contain impurities and needs to be further purified.
Looking at its chemical stability, under conventional environmental conditions, 2- (1H-imidazole-1-yl) -4-pyridineformamide has certain stability. However, when it encounters strong oxidizing agents, strong acids or strong bases, its chemical structure may be damaged, triggering chemical reactions. In practical applications, it is necessary to pay full attention to its chemical environment and avoid contact with these substances that may cause structural changes to ensure its chemical stability and maintain its due function.
In addition, the imidazolyl and pyridineformamide groups in the molecular structure of the compound give it unique chemical activity. The nitrogen atom in the imidazolyl group is rich in lone pair electrons, which easily participates in the coordination reaction and can form stable complexes with metal ions. This property may have potential applications in the fields of materials science and biomedicine. Pyridine formamide group makes the compound have a certain biological activity, or can be used in drug development, as a lead compound for structural optimization to find new drugs with higher biological activity and selectivity.
What is the application prospect of 2- (1H-Imidazol-1-yl) -4-pyridinecarboxamide in the market?
2-%281H-Imidazol-1-yl%29-4-pyridinecarboxamide, this is a chemical substance. Looking at its application prospects in the market, it is quite impressive.
In the field of pharmaceutical research and development, this compound may contribute to the creation of new drugs. Because of its unique chemical structure, or specific biological activity, it can act on specific targets in the human body, and is expected to become a potential drug precursor for the treatment of difficult diseases such as cancer and neurological diseases. Researchers can use in-depth investigation of its interaction with biological macromolecules, carefully optimize its structure, improve its efficacy, and reduce toxic and side effects to develop innovative drugs with excellent efficacy and high safety.
In the field of agriculture, it may emerge as a new type of pesticide or plant growth regulator. With its regulatory effect on physiological processes in organisms, it may enhance the disease resistance of crops, resist the invasion of diseases and pests, and ensure crop yield and quality. It may also regulate plant growth and development, promote seed germination, plant growth, optimize crop morphology, and improve agricultural production benefits.
In terms of materials science, its unique chemical properties may endow materials with novel characteristics. It can be integrated into polymer materials as functional additives to improve the stability, conductivity or optical properties of materials, etc., broaden the application range of materials, and provide new opportunities for the development of electronics, optics and other fields.
However, its application prospects also face challenges. It is necessary to study its toxicological properties in depth to ensure that it is safe and harmless to human body and environment in medicine, agriculture and other applications. The research and development process also requires a significant investment of time and resources for experimentation and optimization in order to realize its potential value.