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What is the chemical structure of 2- [ (1E) -1- (4-methylphenyl) -3-pyrrolidin-1-ylprop-1-en-1-yl] pyridine?
This is the naming of an organic compound. To clarify its chemical structure, it is necessary to analyze it according to the naming rules of organic chemistry. "2 - [ (1E) -1 - (4-methylphenyl) -3 -pyrrolidine-1-ylpropyl-1-ene-1-yl] pyridine" can be solved step by step.
"Pyridine" is the basic structure of a six-membered nitrogen-containing heterocycle and is the core parent ring of this compound. At position 2 of the pyridine ring, there is a complex side chain connected.
"[ (1E) -1 - (4-methylphenyl) -3-pyrrolidine-1-ylpropane-1-ene-1-yl]" In this section, the configuration of the " (1E) " table double bond is E-type, that is, the larger group on both sides of the double bond is in the trans form. "1 - (4-methylphenyl) " is shown in the position 1 of the propane-1-ene-1-group with 4-methylphenyl, and the position 4 of this phenyl group has methyl substitution. " 3-Pyrrolidine-1-yl "refers to the presence of a pyrrolidine group at position 3 of propylene-1-ene-1-yl, and the nitrogen atom of pyrrolidine is connected to the chain.
In summary, the chemical structure of this compound is centered on a pyridine ring, and at position 2, there are side chains containing E-type double bonds, 4-methylphenyl and pyrrolidine groups. The accurate drawing of its structure needs to be explained by organic chemical diagrams such as lines and atomic symbols, but the text expression has fulfilled its structural meaning.
What are the physical properties of 2- [ (1E) -1- (4-methylphenyl) -3-pyrrolidin-1-ylprop-1-en-1-yl] pyridine?
2-%5B%281E%29-1-%284-methylphenyl%29-3-pyrrolidin-1-ylprop-1-en-1-yl%5Dpyridine, this is an organic compound. Its physical properties are related to many factors.
Looking at its shape, under room temperature and pressure, it is difficult to determine whether it is solid or liquid. It is necessary to study its molecular structure and intermolecular forces in detail. If the intermolecular forces are quite strong, such as the existence of hydrogen bonds, van der Waals forces, etc., or more inclined to the solid state; conversely, if the force is weak, it may be a liquid state.
When it comes to the melting point, due to the presence of aromatic rings and heterocycles in the molecular structure, the intermolecular forces are enhanced by the accumulation of π-π between aromatic rings and the characteristics of heterocycles, so the melting point may be higher. However, the specific value needs to be accurately determined by experiments to determine the exact melting point range.
In terms of boiling point, the compound has a moderate molecular weight, and the structure contains polar moieties (pyridine ring and pyrrolidine group), and the boiling point is increased due to the force between polar molecules. However, because the molecule is not extremely large, the boiling point is not unreachable.
In terms of solubility, given that the polar groups containing pyridine ring and pyrrolidine group may have a certain solubility in polar solvents such as alcohols and ketones, due to the principle of "similar miscibility", polar solutes are easily soluble in polar solvents. In non-polar solvents such as alkanes, the solubility may be extremely low, because the non-polar part is relatively limited, it is difficult to be well miscible with non-polar solvents.
The density is related to the degree of close accumulation of molecules and the relative molecular weight. Due to the complexity of the structure, the molecules are piled up or relatively tight, and the relative molecular weight has a certain value, so the density may be greater than that of common organic solvents.
In addition, the compound may have a certain degree of volatility, but due to the intermolecular force, it is volatile or not strong, and it is difficult to quickly evaporate into the air at room temperature.
All these physical properties are closely related to the structure of the compound. The structure determines the properties, and the properties disprove the structural characteristics. Although the exact experimental data are not available, the above inferences are made according to its structural characteristics for reference in exploring the physical properties of this compound.
What are the main uses of 2- [ (1E) -1- (4-methylphenyl) -3-pyrrolidin-1-ylprop-1-en-1-yl] pyridine?
2-%5B%281E%29-1-%284-methylphenyl%29-3-pyrrolidin-1-ylprop-1-en-1-yl%5Dpyridine, this is an organic compound with a wide range of uses. In the field of medicinal chemistry, it is often used as a key intermediate to help develop new drugs. Because of its specific chemical structure, it can interact with targets in organisms, or has the potential to regulate physiological functions, such as affecting the signaling pathways related to certain diseases, laying the foundation for the development of drugs to treat specific diseases.
In the field of materials science, it may be used to prepare functional materials. With its unique chemical properties, it can participate in the material synthesis process and endow materials with special properties, such as improving the optical, electrical or mechanical properties of materials, so as to meet the special requirements of material properties in different application scenarios.
In organic synthetic chemistry, it is an important cornerstone for the construction of more complex organic molecular structures. According to its structural characteristics, chemists can modify and expand its structure through various organic reactions, synthesize a series of organic compounds with diverse structures, enrich the types of organic compounds, and provide more possibilities for the development of organic synthetic chemistry.
Overall, 2-%5B%281E%29-1-%284-methylphenyl%29-3-pyrrolidin-1-ylprop-1-en-1-yl%5Dpyridine is of great significance in many scientific fields, promoting the development and progress of medicine, materials and organic synthesis.
What are the synthesis methods of 2- [ (1E) -1- (4-methylphenyl) -3-pyrrolidin-1-ylprop-1-en-1-yl] pyridine?
To prepare 2 - [ (1E) - 1 - (4 - methylphenyl) - 3 - pyrrolidine - 1 - ylpropyl - 1 - ene - 1 - yl] pyridine, the method of organic synthesis is often followed. First, halogenated pyridine can be obtained by the coupling reaction of halogenated pyridine with boric acid or borate containing a specific alkenyl structure and palladium catalyzed by Suzuki. Halogenated pyridine is prepared first, or a halogen atom is introduced at a specific position in the pyridine ring. Bromine or iodine are commonly used to prepare it to suit the halogenating agent and reaction conditions. At the same time, (1E) -1- (4-methylphenyl) -3-pyrrolidine-1-ylpropyl-1-ene-1-ylboronic acid or borate ester can be prepared by the corresponding halogen and borate ester reagent through metal catalysis. Then, palladium is used as a catalyst, such as tetra (triphenylphosphine) palladium, in the presence of a base, the two are reacted. Bases such as potassium carbonate, sodium carbonate, etc., are heated and stirred in suitable solvents such as toluene, dioxane, etc. Through this step, the two can be coupled to obtain the target product.
Second, Heck reaction can also be used. Halogenated pyridine is used as raw material to react with alkenyl compound under the action of palladium catalyst and base. The alkenyl compound should contain (1E) -1- (4-methylphenyl) -3-pyrrolidine-1-ylpropyl-1-alkenyl-1-yl structure. In the reaction conditions, the palladium catalyst can be selected from palladium acetate, etc., the base can be selected from triethylamine, etc., the solvent can be selected from acetonitrile, etc., and the reaction is heated. The alkenyl group is connected to the pyridine ring to generate the required 2- [ (1E) -1- (4-methylphenyl) -3-pyrrolidine-1-ylpropyl-1-ene-1-yl] pyridine.
The synthesis path requires fine temperature control and time control for each step of the reaction, and the purity of the raw material and the reaction environment are quite strict to improve the yield and purity.
2- [ (1E) -1- (4-methylphenyl) -3-pyrrolidin-1-ylprop-1-en-1-yl] pyridine What are the precautions during storage and transportation?
2-%5B%281E%29-1-%284-methylphenyl%29-3-pyrrolidin-1-ylprop-1-en-1-yl%5Dpyridine is an organic compound, and many key points must be paid attention to during storage and transportation.
Let's talk about storage first. This compound is quite sensitive to environmental factors, and the first temperature is controlled. It should be stored in a cool place. If the temperature is too high, it is easy to change its chemical properties and even cause undesirable conditions such as decomposition. Therefore, the warehouse temperature should be carefully maintained in an appropriate range, generally 5 to 25 degrees Celsius.
Humidity should not be underestimated. Humid environment may make the compound absorb moisture, which in turn affects its purity and stability. The warehouse needs to be kept dry, and the relative humidity should be controlled at 40% to 60%. And it should be stored in a sealed container to avoid excessive contact with air to prevent reactions such as oxidation.
As for transportation, the compound may have certain chemical activity and potential danger. Before transportation, the packaging must be tight, and professional and suitable packaging materials must be used to prevent leakage. During transportation, avoid violent vibration and collision, damage to the package due to mechanical force or even chemical reactions.
The environmental conditions of the transportation vehicle are also critical, and the appropriate temperature and humidity should be maintained, which is similar to the storage requirements. At the same time, the transportation personnel need to be professionally trained, familiar with the characteristics of the compound and emergency treatment methods. In the event of an accident, they can respond quickly and properly to reduce the harm.
In addition, whether it is storage or transportation, it is necessary to strictly follow the relevant regulations and standards, make records and labels, and ensure that the source, whereabouts and status are clear and traceable, so as to ensure the safety and stability of 2-%5B%281E%29-1-%284-methylphenyl%29-3-pyrrolidin-1-ylprop-1-en-1-yl%5Dpyridine in all links.