1H-pyrrolo[3,2-c]pyridine, 4-chloro-2,3-dihydro-

1H-pyrrolido [3,2-c] pyridine, 4-fluoro-2,3-dihydro, has a wide range of main application fields. In the field of medicinal chemistry, this compound is often a key intermediate. Due to its unique chemical structure, it can be linked to many active groups by organic synthesis to create drug molecules with specific pharmacological activities. For example, when developing anti-tumor drugs, such structures may be modified to achieve precise effects on specific targets of tumor cells, by interfering with the growth, proliferation or signal transduction pathways of tumor cells, to achieve the effect of inhibiting tumors.
In the field of materials science, this compound also shows potential application value. Due to the nitrogen-containing heterocyclic structure endowing it with certain electronic properties, it may be used to prepare organic optoelectronic materials. After rational molecular design and synthesis, materials with good photoelectric conversion efficiency and fluorescence properties may be obtained, which will play a role in the preparation of organic Light Emitting Diode (OLED), solar cells and other devices.
In pesticide chemistry, 1H-pyrrolido [3,2-c] pyridine derivatives may have insecticidal and bactericidal activities. Through structural modification and optimization, new pesticides with high efficiency, low toxicity and environmental friendliness can be developed, providing a new way for agricultural pest control.

The synthesis method of 1H-pyrrolido [3,2-c] pyridine, 4-fluoro-2,3-dihydro-can follow the following general paths:
First, the structure of the pyridine ring is built by palladium-catalyzed coupling reaction with nitrogen-containing heterocycles and halogenated aromatics as starting materials. Among them, the activity of the halogenated aromatics is very important, and it is necessary to choose the appropriate activity to make the reaction smooth. The choice of palladium catalyst should not be underestimated. Different palladium catalysts have different reaction rates and yields, so they need to be carefully identified. The alkali in the reaction system also has a great influence on the reaction, which can not only promote the reaction, but also regulate the selectivity of the reaction.
Second, specific ketones and amines are used as raw materials to obtain a series of reactions such as condensation and cyclization. In the condensation stage, it is necessary to strictly control the reaction temperature and time to fully react ketones and amines to form key intermediates. In the cyclization step, a specific dehydrating agent or acidic catalyst may be added to promote the cyclization of the molecule to construct the target pyrrolido-pyridine structure. In this process, the proportion of the reactants also needs to be precisely prepared, and improper proportions can easily lead to side reactions and reduce the purity and yield of the product.
Third, a simple pyrrole or pyridine fragment can be constructed first by a multi-step reaction strategy, and then the two can be spliced together through subsequent reactions. Although there are many steps in this path, the reaction conditions at each step are relatively mild and easy to control. The purification of the intermediate at each step is extremely critical. Only by ensuring the purity of the intermediate can the subsequent reaction occur as expected and finally obtain the target product. And the connection between each step of the reaction needs to be carefully planned, considering the stability and reactivity of the intermediate, to ensure the feasibility and efficiency of the entire synthesis route.

The physical and chemical properties of 1H-pyrrolido [3,2-c] pyridine, 4-chloro-2,3-dihydro are as follows:
The appearance of this compound may be a crystalline solid, with a specific melting point and boiling point. The melting point may vary due to purity and measurement methods. Usually in organic synthesis, its melting point can help confirm purity and identify structure. The boiling point affects its behavior in separation processes such as distillation.
In terms of solubility, because of its nitrogen-containing heterocyclic ring and chlorine atom, it has a certain solubility in organic solvents, or in common organic solvents such as dichloromethane and chloroform, because these solvents and compounds can form van der Waals forces and other interactions. However, the solubility in water may be limited. Due to the relatively strong non-polarity of the molecule as a whole, the ability to form hydrogen bonds with water molecules is weak.
In terms of stability, the compound is relatively stable at room temperature and pressure and in a dry environment. However, due to its active chlorine atoms, chlorine atoms are easily replaced in the presence of nucleophiles, triggering nucleophilic substitution reactions. In case of strong oxidants, nitrogen heterocycles may be partially oxidized, which affects the structure and properties. And at high temperatures, molecular structures may undergo reactions such as rearrangement.
Spectral properties are unique. In hydrogen nuclear magnetic resonance spectroscopy (H-NMR), hydrogen atoms in different chemical environments will give specific chemical shift signals, which can help determine the position and number of hydrogen atoms. Carbon spectra can provide information on the chemical environment of carbon atoms. In infrared spectra (IR), characteristic functional groups such as C-Cl bonds, N-H bonds (if any) will appear corresponding absorption peaks, providing strong evidence for structure identification.

What you are asking is the price of 1H-pyrrolido [3,2-c] pyridine, 4-fluoro-2,3-dihydro in the market. Sadly, I have not obtained a detailed price in the current market. Because the market is fickle, its price often varies with supply and demand, origin, quality, and season.
If you want to know the exact price, you can visit the chemical raw material trading market and ask the merchant, who may be able to tell you the recent price. Or you can check it on the chemical product e-commerce platform. There are many prices of various chemicals on the platform for reference. There are also chemical information agencies. They often collect market data and analyze the trend of their prices, which may be able to solve your doubts.
Although I cannot tell you the price directly, following this path, you may be able to obtain an approximate price to meet your needs.

I look at your question, it is about the manufacturer of 1H-pyrrolido [3,2-c] pyridine, 4-chloro-2,3-dihydrogen. The production of these chemicals is related to many fine chemical and pharmaceutical chemical fields.
In China, there are many manufacturers involved in this. For example, a factory in Jiangsu, which is good at fine chemical synthesis, has considerable experience in the production of pyridine compounds, and its exquisite process can produce this product in an efficient way, and the quality is high, which is favored by many downstream enterprises.
Another example is an enterprise in Zhejiang, which focuses on the manufacture of pharmaceutical and chemical raw materials. It invests a lot in the research and development and production of 1H-pyrrolido [3,2-c] pyridine, 4-chloro-2,3-dihydrogen. It has advanced equipment and a professional team, and the purity of the products is very high, which can meet the needs of the high-end pharmaceutical market.
Shandong also has manufacturers. With the advantages of the chemical industry cluster, it integrates resources and optimizes processes. In the production of such compounds, the cost is properly controlled, and the products are quite competitive in terms of cost performance. It also occupies a place in the domestic market.
Furthermore, the chemical enterprises in Shanghai, with their geographical and technological advantages, have cooperated with universities and scientific research institutions to continuously improve the production process, and their output of 1H-pyrrolido [3,2-c] pyridine, 4-chloro-2,3-dihydro is commendable in terms of quality and innovation.
All these factories are important producers of 1H-pyrrolido [3,2-c] pyridine and 4-chloro-2,3-dihydro, each developing its own strengths and promoting the development of this field.