1H-Pyrrolo[3,2-c]pyridine-3-carboxylicacid

The chemical structure of 1H-pyrrolido [3,2-c] pyridine-3-carboxylic acids is a key content in the field of organic chemistry. Its structural characteristics contain unique atomic arrangements and chemical bonding methods.
This compound is formed by fusing the pyridine ring with the pyrrole ring to form a unique fused ring system. In this system, the pyridine ring has a six-membered nitrogen-heterocyclic ring structure, and the pyrrole ring is a five-membered nitrogen-containing heterocyclic ring. The two fused in a specific way to construct a complex multi-ring structure.
In 1H-pyrrolido [3,2-c] pyridine-3-carboxylic acid, a carboxyl (-COOH) functional group is connected at a specific position in the pyrrolido-pyridine fused ring structure, that is, position 3. The presence of this carboxyl group endows the compound with specific chemical properties and reactivity.
Carboxyl groups are acidic and can participate in many chemical reactions, such as acid-base neutralization and esterification. The pyrrolido-pyridine fused ring structure also endows the compound with a unique electron cloud distribution and spatial configuration, which affects its physicochemical properties and biological activities. Compounds with such structures often show potential application value in the fields of medicinal chemistry and materials science, or can be used as lead compounds in drug development or play a key role in material synthesis. Their unique chemical structures provide an important structural basis for the exploration of new functional materials and high-efficiency drugs.

1H-pyrrolido [3,2-c] pyridine-3-carboxylic acid, an organic compound. It has a wide range of uses in the field of medicinal chemistry and is often a key intermediate in the synthesis of many biologically active compounds. Due to the unique chemical structure of this compound, it can interact with specific targets in organisms, so it is often used in the process of drug development to build molecular structures with potential therapeutic effects.
It also has applications in the field of materials science. Or through specific chemical reactions, materials with special photoelectric properties can be prepared, such as used in organic Light Emitting Diode (OLED), solar cells and other devices, with its unique electronic structure to improve the charge transport and luminescence properties of materials.
In the field of organic synthesis, 1H-pyrrolido [3,2-c] pyridine-3-carboxylic acid is an important building block, which can participate in the construction of various complex organic molecules. With its carboxyl group and pyrrolido-pyridine structure reactivity, it can introduce different functional groups through esterification, amidation and other reactions, expand the structural diversity of compounds, and provide an effective way for the synthesis of novel organic compounds.
Furthermore, in chemical biology research, probe molecules built on this compound may be used to track specific biological processes in organisms, label biomolecules, and help scientists delve deeper into the molecular mechanisms in organisms.

The synthesis method of 1H-pyrrolido [3,2-c] pyridine-3-carboxylic acid can be obtained from many ways.
One, or can be initiated by a pyridine derivative with a suitable substituent group. Before introducing a specific functional group at a specific position of the pyridine ring, through a halogenation reaction, a hydrogen atom on the pyridine ring is replaced by a halogen, such as chlorine or bromine. This halogenated pyridine derivative is then reacted with a pyrrole-containing reagent in a suitable base and solvent environment. The choice of bases, such as potassium carbonate, sodium carbonate, etc., the solvent can be selected from dimethylformamide (DMF), dimethyl sulfoxide (DMSO) and the like. The basic structure of pyrrolido-pyridine can be constructed by the reaction of the two. After oxidation, specific groups are converted into carboxyl groups. Commonly used oxidants, such as potassium permanganate, potassium dichromate, etc., result in 1H-pyrrolido [3,2-c] pyridine-3-carboxylic acid.
Second, pyrrole derivatives can also be used as starting materials. First, the pyrrole ring is modified to introduce the substituent required for the construction of the pyridine ring. Pyridine-containing structural fragments are introduced on the pyrrole ring through the Friedel-Crafts reaction. Lewis acids such as aluminum trichloride are used as catalysts and react in suitable solvents such as dichloromethane. After that, the cyclization reaction prompts the pyrrole to connect with the pyridine fragment to form a ring. The cyclization reaction conditions may require heating and specific catalysts, such as copper salt catalysis. After cyclization, the obtained product is further modified, and the carboxylation reaction, such as carbon dioxide as the carboxyl source, converts the specific group into a carboxyl group in the presence of a suitable base and catalyst, so as to obtain the target product 1H-pyrrolido [3,2-c] pyridine-3-carboxylic acid.
Third, there is a strategy to use a simple straight-chain compound as the starting material. First, through a multi-step reaction, the prototype of pyrrole ring and pyridine ring is constructed respectively, and then through an intramolecular cyclization reaction, the pyrrole-pyridine structure is formed in one step. For example, pyrrole and pyridine fragments are constructed from simple compounds containing nitrogen and carbon through a series of reactions such as condensation and cyclization, and then cyclized under suitable conditions, such as high temperature, strong basic environment or specific metal catalysis. Subsequent functional group conversion converts the specific group into a carboxyl group. If treated with suitable oxidation reagents or carboxylating reagents, the synthesis of 1H-pyrrole [3,2-c] pyridine-3-carboxylic acid is achieved.

1H-pyrrolido [3,2-c] pyridine-3-carboxylic acid, the physical properties of this substance are quite important and relevant to its many applications.
Its appearance is often white to light yellow crystalline powder, fine and uniform in texture. This morphology is easy to identify and has a deep impact on its subsequent treatment and use.
When it comes to melting point, it is usually within a specific temperature range, about [X] ° C to [X] ° C. Melting point is an inherent characteristic of a substance, and accurate melting point data can help to identify its purity. If it contains impurities, the melting point may be offset, so the determination of melting point is a key part of quality control.
Solubility is also a key property. In organic solvents, such as dimethyl sulfoxide (DMSO), N, N-dimethylformamide (DMF), etc., it has good solubility and can quickly disperse and dissolve to form a homogeneous solution. However, it has poor solubility in water and is only slightly soluble. This difference in solubility is an important basis for solvent selection in drug research and development and chemical synthesis process design.
In terms of density, after accurate measurement, its density is about [X] g/cm ³. The density is related to the accumulation and space occupation of substances, and it is of great significance in storage, transportation and industrial production.
In addition, the stability of the substance is good, and it can maintain its own structure and properties under conventional environmental conditions. However, in case of extreme conditions such as high temperature, strong acid, and strong alkali, or chemical reactions occur, the structure changes and the properties also change. Therefore, storage needs to avoid such extreme factors to ensure the stability of its physical properties for subsequent use.

I look at you and ask "What is the price range of 1H - Pyrrolo [3,2 - c] pyridine - 3 - carboxylic acid in the market". However, the price of this product often changes due to many factors, and it is difficult to determine the exact price.
First, the purity of the product has a great impact on the price. If the purity is very high, it is almost flawless, and the price is high; on the contrary, if the purity is slightly lower, the price is also low. For example, those with a purity of 99%, or those with a purity of 95%, the price is several times higher.
Second, the market supply and demand situation also affects its price. If the demand is strong and the supply is scarce, the so-called "scarcity is the most expensive", the price will rise; if the supply exceeds the demand, the price will stabilize or even decline.
Third, the price varies depending on the manufacturer. Well-known large factories, due to their exquisite production technology and stable product quality, their price may be higher than that of ordinary manufacturers.
Fourth, the purchase quantity is also related to the price. Bulk purchasers, merchants often treat each other at preferential prices, the so-called "large quantity is better", which is a market practice.
Generally speaking, in small packages commonly used in laboratories, those with higher purity may cost between tens of yuan and hundreds of yuan per gram. If it is industrial grade and large-scale procurement, according to the above factors, the price per ton may range from tens of thousands to hundreds of thousands of yuan. However, this is only a rough estimate, and the actual price should be subject to the quotation of each supplier.