1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid, 5-methoxy-

1H-pyrrolido [3,2-b] pyridine-2-carboxylic acid, 5-methoxy-This physical property is particularly important, depending on its use and reaction path.
From the perspective of its properties, it may be in a solid state at room temperature. Because the molecule is rich in polar groups, such as carboxyl and methoxy, it may have certain solubility in polar solvents, such as alcohols and aqueous phases. However, the acidity of the carboxyl group can make it more soluble in alkaline media, forming corresponding salts.
When it comes to the melting point, although there is no conclusive data, it is inferred from its structure, or due to the existence of intermolecular hydrogen bonds and conjugate systems, the melting point is higher. In this structure, the conjugated system of pyridine and pyrrole imparts considerable stability to the molecule, and high energy is required to disintegrate the lattice.
As for the boiling point, due to the complex intermolecular forces, in addition to van der Waals forces, hydrogen bonds also contribute, so the boiling point is not low.
In terms of spectral characteristics, in the infrared spectrum, the stretching vibration peak of the carboxyl group can be observed around about 1700 cm ², which is the characteristic peak of the carboxyl group; the C-O stretching vibration of the methoxy group, or the peak appears in the range of 1000-1300 cm ². In hydrogen NMR spectroscopy, hydrogen atoms in different chemical environments will peak at the corresponding chemical shifts, such as methoxy hydrogen, or peak at about 3.8 ppm, which can be used for structural confirmation.
The physical properties of this compound lay the foundation for its application in organic synthesis, drug development and other fields. Scholars need to observe it in detail to clarify its properties and make good use of its properties.

5-Methoxy-1H-pyrrolido [3,2-b] pyridine-2-carboxylic acid, this is an organic compound. Looking at its structure, it contains a pyrrolido-pyridine parent nucleus, and is connected with a methoxy group at the 5th position and a carboxyl group at the 2nd position.
In terms of its physical properties, it is usually in a solid state, but the specific melting point needs to be accurately determined according to experiments. Its solubility, due to the hydrophilicity of the carboxyl group in the molecule, and the hydrophobicity of the methoxy group and the aromatic ring, may have a certain solubility in polar organic solvents such as methanol, ethanol, and dimethyl sulfoxide, and its solubility in water may be limited.
When it comes to chemical properties, the carboxyl group can exhibit acidic properties, and can neutralize with bases to form corresponding carboxylic salts. This compound can also participate in esterification reactions, and react with alcohols to form esters under suitable catalyst and reaction conditions. Its aromatic ring structure endows it with certain aromaticity, and it can undergo electrophilic substitution reactions, such as halogenation, nitration, sulfonation, etc. The substitution check point is affected by the localization effect of methoxy and carboxyl groups. Methoxy group as the power supply group may increase the electron cloud density of the aromatic ring, which makes the electrophilic substitution reaction more likely to occur, and the substituent group may mainly enter the methoxy ortho and para-position. In addition, the nitrogen atom in the parent nucleus of pyrrolidopyridine may have certain alkalinity and can It can be used as a key intermediate to prepare various nitrogen-containing heterocyclic derivatives, and is used in many fields such as medicinal chemistry and materials science.

1H-pyrrolido [3,2-b] pyridine-2-carboxylic acid, 5-methoxy group, its main uses are as follows:
This compound has great potential for pharmaceutical research and development. Its unique structure may be compatible with specific biological targets, and then it will make a name for itself in the field of drug creation. Physicians seeking new therapeutic agents against various diseases, such as tumors, diseases of the nervous system, or inflammation, often rely on these compounds as starting materials, carefully modified to obtain new drugs with ideal pharmacological activity and safety.
It is also a key intermediate in the process of organic synthesis. The craftsman of organic synthesis uses it as a cornerstone to use various ingenious reactions to build more complex and functional organic molecular structures. This helps to expand the variety of organic compounds, enrich the treasure house of chemical substances, and provide a variety of raw materials for the development of materials science and other fields.
In the field of materials science, there are also potential uses. If its structure can be properly modified, it may be able to endow materials with unique photoelectric and electrical properties, which can be used in the preparation of new optoelectronic devices, sensors, etc., to open up new paths for material innovation. In summary, 1H-pyrrolido [3,2-b] pyridine-2-carboxylic acid, 5-methoxy group, has a great potential in many fields such as medicine, organic synthesis and materials science.

The synthesis method of 5-methoxy-1H-pyrrolido [3,2-b] pyridine-2-carboxylic acid covers the chemical synthesis process, which needs to be based on its structural characteristics and reaction mechanism.
First look at the structure of this compound, which contains a ring system of pyrrolido and pyrrole, and has methoxy and carboxyl groups attached to it. To synthesize this compound, you can start with the construction of pyrrolido-pyridine ring.
Alternatively, a suitable pyridine derivative can be used as the starting material, and a suitable substituent can be introduced at a specific position of the pyridine ring to lay the foundation for the subsequent construction of pyrrole ring. For example, a pyridine derivative is introduced into a halogen atom at a specific carbon site through a halogenation reaction, and the halogen atom can be the activity check point for subsequent nucleophilic substitution reactions.
Then, the classical reaction of nitrogen-containing heterocyclic synthesis is used, such as the reaction of nitrogen-containing nucleophilic reagents with halogenated pyridine derivatives, and the nucleophilic substitution is used to preliminarily construct the ring system of pyrrolido-pyridine. At this time, the obtained ring system or methoxy group and carboxyl group are still lacking. The introduction of
methoxy group can be used by means of a nucleophilic substitution reaction to react with a suitable methoxylating reagent with a precursor to connect the As for the carboxyl group, the nitrile group can be introduced at an appropriate stage by the method of hydrolysis of the nitrile group, and then hydrolyzed to convert it into a carboxyl group. In this way, after a multi-step reaction, it can be obtained as this 5-methoxy-1H-pyrrolido [3,2-b] pyridine-2-carboxylic acid. However, the process of synthesis requires fine regulation of the reaction conditions, such as temperature, solvent, catalyst, etc., to ensure that the reaction proceeds in the expected direction and a pure product is obtained.

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