1H-Pyrrolo[2,3-c]pyridine, 3-bromo-

3-Bromo-1H-pyrrolido [2,3-c] pyridine is one of the organic compounds. It has many unique chemical properties.
Looking at its structure, it contains the skeleton of pyrrolido-pyridine and has bromine atoms attached at the 3rd position. This structural feature makes its chemical activity quite special. Bromine atoms have certain electronegativity, which can change the distribution of molecular electron clouds, which in turn affects the reactivity.
In nucleophilic substitution reactions, bromine atoms are good leaving groups. Due to its electronegativity, the carbon-bromine bond electron cloud is biased towards bromine, making the carbon atoms partially positively charged and vulnerable to nucleophilic reagents. Nucleophiles such as alcohols and amines can attack the positively charged carbon atoms, and bromine ions leave to form new compounds.
Furthermore, this compound is alkaline due to its nitrogen heterocycle. Nitrogen atoms have lone pairs of electrons and can accept protons. In acidic environments, nitrogen atoms easily combine with protons to form salts. This property is of great significance in the fields of medicinal chemistry and organic synthesis. It can help them combine with other acidic substances to achieve specific reactions or be used in preparations.
In addition, its conjugate system has an impact on light and thermal stability. The conjugate system can reduce the molecular energy and stabilize the structure. However, under certain conditions, such as strong light or high temperature, the conjugated system may be destroyed, triggering chemical reactions and causing molecular structure changes.
In organic synthesis, 3-bromo-1H-pyrrolido [2,3-c] pyridine is often used as an intermediate. Due to its special structure and reactivity, complex organic molecules can be constructed through various reactions, providing a key foundation for drug development, materials science and other fields.

3-Bromo-1H-pyrrolido [2,3-c] pyridine has a wide range of uses. In the field of medicinal chemistry, it is a very critical organic intermediate.
This compound can be used to create new drugs. Due to its unique chemical structure, it can bind to specific targets in organisms, thereby exhibiting diverse biological activities. Or it can act on specific enzymes and inhibit their activity for the purpose of treating diseases. For example, in the development of anti-tumor drugs, it can target abnormally expressed protein kinases in tumor cells by binding to specific regions of the kinase, blocking its signal transduction pathway, thereby inhibiting the growth and proliferation of tumor cells.
In the field of materials science, 3-bromo-1H-pyrrolido [2,3-c] pyridine is also used. Because of its conjugated structure, it can be used as a basic unit for constructing functional materials. After rational molecular design and synthesis, materials with special photoelectric properties can be prepared, such as in the field of organic Light Emitting Diode (OLED), which may improve the luminous efficiency and stability of devices and improve the display effect.
In addition, in organic synthetic chemistry, it is often used as a key building block to participate in the construction of complex organic molecules. Through various organic reactions, such as halogenation reactions, coupling reactions, etc., different functional groups can be introduced to expand the structural diversity of molecules, providing the possibility for the synthesis of organic compounds with specific functions and structures, and promoting the in-depth development of organic synthetic chemistry.

To prepare 3-bromo-1H-pyrrolido [2,3-c] pyridine, the method is as follows:
First, 1H-pyrrolido [2,3-c] pyridine is used as the starting material, liquid bromine or N-bromosuccinimide (NBS) as the bromine source, in suitable solvents such as dichloromethane and chloroform, at low temperature or room temperature, or in the presence of light and initiator. Due to the structural characteristics of 1H-pyrrolido [2,3-c] pyridine, the bromine atom is easily reduced to the 3-position.
If liquid bromine is used as the bromine source, dissolve 1H-pyrrolido [2,3-c] pyridine into dichloromethane, cool to about 0 ° C, slowly add the dichloromethane solution of liquid bromine dropwise, add it dropwise, and stir at room temperature for a few hours. After washing with sodium bicarbonate solution, drying with anhydrous sodium sulfate, distillation under reduced pressure, and purification by column chromatography, the product can be obtained.
If N-bromosuccinimide is used, 1H-pyrrolido [2,3-c] pyridine and NBS are added to chloroform in a suitable ratio, and a small amount of benzoyl peroxide is added as the initiator. Heat the reflux reaction. After the reaction is completed, the solid is cooled, filtered, and the filtrate is washed, dried, distilled, and column chromatography according to the previous method to obtain 3-bromo-1H-pyrrolido [2,3-c] pyridine.
There are also derivatives containing pyrrolido [2,3-c] pyridine structure as raw materials. After multi-step reaction, a transformable group is introduced first, and then it is converted into a bromine atom through appropriate reaction to obtain the target. However, this approach has many steps, and the reaction route needs to be carefully planned and the reaction conditions of each step are controlled in order to achieve the purpose of efficient synthesis.

What you are inquiring about is the price range of 1H-pyrrolido [2,3-c] pyridine-3-bromide in the market. However, the price of this product is difficult to determine, and it is affected by many factors.
First, the purity of this compound has a great impact on the price. If the purity is very high and reaches the scientific research level, the preparation process will be complicated, the cost will be huge, and the price will be high. If the purity reaches more than 99%, the price per gram may reach hundreds of gold spectra.
Second, the situation of supply and demand is also key. If there is a strong demand for this product in the market and the supply is scarce, the price will rise. On the contrary, if there is little demand and sufficient supply, the price may decline.
Third, the place of production and the channel are also related. The origin is from a well-known large factory, and the quality control is strict. The price may be higher than that of an ordinary small factory. And different sales channels, such as purchasing directly from the manufacturer, or changing hands through intermediaries, the price also varies.
Overall, the price of 1H-pyrrolido [2,3-c] pyridine-3-bromide fluctuates between tens of gold and hundreds of gold per gram. The specific number depends on the above factors. To know the exact price, you need to consult the relevant suppliers in detail to obtain the exact number.

3-Bromo-1H-pyrrolido [2,3-c] pyridine is an organic compound, and its safety precautions are described as follows:
This substance is potentially chemically hazardous. Chemically, the presence of bromine atoms increases the activity of the compound. Bromine atoms are more active, and under certain conditions, they may participate in substitution, addition and other reactions. If there are substances that are easy to react in the operating environment, or cause unexpected chemical reactions, such as encounters with strong oxidants, there is a risk of violent reactions or even explosions. Therefore, when conducting reactions involving this compound, it is necessary to clarify its chemical activity in advance and operate with caution to prevent contact with incompatible substances.
In terms of physical properties, its appearance, odor and other characteristics also need to be paid attention to. Although its specific physical properties are not known, most organic compounds may have a special odor, and some odors may be irritating, causing irritation to the respiratory tract. If it is a volatile substance, it evaporates in the air, or causes air pollution, endangering human health. The operation should be carried out in a well-ventilated environment, such as a fume hood, to reduce the concentration of the substance in the air.
From the perspective of toxicity, although there is no exact toxicity data, many organic compounds containing nitrogen and bromine may have certain toxicity. Or enter the human body through inhalation, skin contact, ingestion, etc., causing damage to the human body, such as damage to the liver, kidneys and other organs, affecting the function of the nervous system. Appropriate protective measures must be taken during operation, such as wearing protective gloves to avoid direct contact with the skin; wearing a gas mask to prevent inhalation of its dust or volatile gases; do not eat or drink during operation to prevent accidental ingestion.
In addition, when storing the compound, it should be placed in a cool, dry and well-ventilated place, away from fire and heat sources, and away from direct sunlight. At the same time, it needs to be stored separately from oxidants, acids, alkalis and other substances to prevent reactions. The storage area should be equipped with corresponding fire equipment and leakage emergency treatment equipment for emergencies. In case of accidental leakage, personnel from the leakage contaminated area should be quickly evacuated to a safe area and isolated, and access should be strictly restricted. It is recommended that emergency personnel wear self-contained positive pressure breathing apparatus and anti-gas clothing to cut off the leakage source as much as possible. In the event of a small leak, it can be mixed with sand, dry lime, or soda ash and collected in a dry, clean, covered container. In the event of a large leak, build a dike or dig a pit to contain it, cover it with foam to reduce the vapor hazard, and then collect, transfer, recycle, or dispose of it harmlessly.