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What is the main use of 1H-pyrrolido [2,3-c] pyridine, 3-bromo-5-chloro-?
1H-pyrrolido [2,3-c] pyridine, 3-bromo-5-fluorine, has a wide range of uses. In the field of medicine, it is a key organic synthesis intermediate and can be used to create new drugs. In the process of many drug development, through structural modification and modification, compounds with specific physiological activities and pharmacological properties can be obtained to target specific disease targets, such as when developing anti-tumor drugs, or when it can be used to construct active molecules with unique structures to achieve precise inhibition of tumor cell growth and proliferation.
In the field of materials science, it can participate in the preparation of materials with special photoelectric properties. Due to its unique structure, the material is endowed with specific properties in light absorption, emission and charge transport, and can be applied to the manufacture of optoelectronic devices such as organic Light Emitting Diode (OLED) and solar cells to improve the performance and efficiency of the device.
also plays an important role in pesticide research and development. It can be used as a starting material or key structural unit for the synthesis of highly efficient, low toxic and environmentally friendly pesticides. With its structural characteristics, pesticides with high selectivity and high activity for specific pests can be designed and synthesized, providing strong support for agricultural pest control.
In conclusion, 1H-pyrrolido [2,3-c] pyridine, 3-bromo-5-fluorine are of great significance in the fields of medicine, materials and pesticides, and their application prospects will be broader with the deepening of scientific research.
What are the physical properties of 1H-pyrrolido [2,3-c] pyridine, 3-bromo-5-chloro-
The properties of 1H-pyrrolido [2,3-c] pyridine, 3-bromo-5-fluorine are as follows:
Its appearance is usually white to off-white crystalline powder. This is due to the arrangement and combination of various atoms in the molecular structure, which causes it to form such an aggregated state at room temperature and pressure, which is easy to identify and follow-up processing.
When it comes to melting points, they are usually in a specific temperature range, which is determined by the intermolecular forces. Intermolecular interactions such as van der Waals forces and hydrogen bonds require molecules to absorb specific energy in order to break free from lattice constraints and transform from solid to liquid.
In terms of solubility, it has a certain solubility in organic solvents such as dichloromethane and N, N-dimethylformamide. This is due to the fact that similar intermolecular forces can be formed between the molecules of the substance and the molecules of the organic solvent, following the principle of "similar phase dissolution". However, the solubility in water is very small, because the interaction of water molecules dominated by hydrogen bonds and the intermolecular forces of the substance are quite different, it is difficult to intersperse and dissolve each other.
In terms of stability, it is relatively stable under conventional conditions. However, it should be noted that because it contains halogen atoms such as bromine and fluorine, it may initiate chemical reactions and cause structural changes when exposed to specific chemical reagents such as strong oxidants and strong bases. For example, in a strong alkali environment, halogen atoms may undergo a substitution reaction, which affects their chemical properties.
From the perspective of spectral properties, in infrared spectroscopy, due to the vibration of various chemical bonds on pyrrole rings and pyridine rings, there will be absorption peaks of specific wavenumbers. These absorption peaks are like "fingerprints" of molecules and can be used for qualitative identification. In hydrogen nuclear magnetic resonance spectroscopy, hydrogen atoms in different chemical environments will show different signal peaks of chemical shifts, which can infer the number of hydrogen atoms in the molecule and the chemical environment in which it is located, which can help determine its molecular structure.
What are the chemical properties of 1H-pyrrolido [2,3-c] pyridine, 3-bromo-5-chloro-
The chemical properties of 1H-pyrazolo [2,3-c] pyridine, 3-bromo-5-fluorine are unique and valuable for investigation. This compound is different from common organic compounds due to the combination of pyrazole and pyridine in its structure.
From the perspective of electron cloud distribution, the pyrazole ring is conjugated with the pyridine ring, so that the electron cloud density is redistributed across the molecular skeleton. The nitrogen atom of the pyridine ring has an electron-absorbing effect, and the nitrogen atom on the pyrazole ring also affects the electron cloud distribution, which makes the molecular electronic structure complex. This property affects its chemical reactivity. In the electrophilic substitution reaction, due to the difference in electron cloud density distribution, the reactivity at different positions is different, and the specific position may be more susceptible to the attack of electrophilic reagents.
The introduction of bromine and fluorine atoms greatly changes the molecular physical and chemical properties. Fluorine atoms have extremely strong electronegativity, which can significantly enhance molecular polarity and affect their solubility and intermolecular forces. When interacting with other substances, fluorine atoms can participate in hydrogen bonds or other weak interactions by virtue of strong electronegativity, which can change the physical and chemical behavior of compounds. Bromine atoms are relatively large, and their presence increases molecular steric resistance. In chemical reactions, spatial factors have a great impact on the reaction process and product selectivity. For example, in some substitution reactions, the space around the bromine atom hinders or restricts the proximity of the reagent, thereby changing the reaction path and the ratio of the product.
In addition, 1H-pyrazolo [2,3-c] pyridine, 3-bromo-5-fluorine also have unique performances in redox reactions. Due to the influence of the conjugate system and the halogen atom, its ability to gain and lose electrons is different from that of ordinary hydrocarbon compounds, or exhibits a specific redox potential, which plays a special role in reactions involving electron transfer. In short, this compound has rich and complex chemical properties due to its unique structure and substitution of halogen atoms, and has broad research and application prospects in organic synthesis, medicinal chemistry and other fields.
What is the synthesis method of 1H-pyrrolo [2,3-c] pyridine, 3-bromo-5-chloro-
To prepare 1H-pyrrolido [2,3-c] pyridine, 3-bromo-5-chlorine, the following steps can be followed.
Take a suitable pyridine derivative first, and use a brominating agent to interact with it to replace the bromine atom at a specific position. Commonly used brominating agents, such as liquid bromine, N-bromosuccinimide (NBS), etc. If NBS is used, in a suitable organic solvent, such as carbon tetrachloride, in the presence of an initiator such as benzoyl peroxide, heating or lighting can selectively replace the bromine atom at a specific position in the pyridine ring to obtain a bromine-containing pyridine intermediate. < Br >
Next, the bromine-containing intermediate is treated with a chlorinating agent. Select suitable chlorinating agents, such as thionyl chloride, phosphorus oxychloride, etc. Under appropriate reaction conditions, the chlorinating agent reacts with the intermediate to replace the group at the target position with a chlorine atom, thereby introducing a chlorine atom to obtain a pyridine derivative of 3-bromo-5-chloro.
Subsequently, this pyridine derivative of 3-bromo-5-chloro is used as a raw material and reagents containing pyrrole structures are reacted in a suitable organic solvent under alkali catalysis. The alkali can be selected from potassium carbonate, potassium tert-butyl alcohol, etc., and the organic solvent can be selected from dichloromethane, N, N-dimethylformamide (DMF), etc. After condensation reaction, the pyridine ring is connected to the pyrrole ring to construct the basic skeleton of 1H-pyrrolido [2,3-c] pyridine.
After the reaction is completed, the product is purified by conventional separation and purification methods, such as column chromatography, recrystallization method, etc., and the unreacted raw materials, by-products and other impurities are removed, and the purified 1H-pyrrolido [2,3-c] pyridine and 3-bromo-5-chlorine products are finally obtained. Throughout the process, it is necessary to pay attention to the precise control of the reaction conditions, including temperature, time, and reagent dosage, etc., in order to ensure the efficient and smooth progress of the reaction and achieve the ideal product yield and purity.
In which fields is 1H-pyrrolido [2,3-c] pyridine, 3-bromo-5-chloro-used?
1H-pyrazolo [2,3-c] pyridine, 3-bromo-5-fluorine are used in medicine, materials and other fields.
In the field of medicine, it can be used as a drug intermediate. Due to its special chemical structure, it can participate in many drug synthesis reactions and help develop new drugs. For example, in the development of anti-tumor drugs, it may introduce drug molecules through specific reaction steps, and by virtue of its structural characteristics, adjust the effect of drugs and targets, improve drug activity and selectivity, and provide a new direction for the treatment of tumor diseases.
In the field of materials, it also has performance. Because of its nitrogen-containing heterocyclic structure and bromine and fluorine atoms, it may endow materials with unique optoelectronic properties. For example, in organic Light Emitting Diode (OLED) materials, the introduction of this structure through rational molecular design may optimize the material's luminous efficiency, stability and other properties, and promote the development of display technology. In addition, in the preparation of some functional polymer materials, it can be used as a structural unit to endow the material with special chemical and physical properties to meet the needs of different application scenarios.
