1H-pyrrolo[2,3-b]pyridine, 5-methyl-

1H-pyrrole [2,3-b] pyridine-5-methyl, its chemical properties are quite important. This compound has a unique structure, formed by the combination of pyrrole and pyridine, and has a methyl group at the 5th position.
From the perspective of physical properties, it is usually in a solid state, and its melting point and boiling point are determined by intermolecular forces. Due to the existence of a conjugate system within the molecule, it has a certain stability. Its solubility is related to molecular polarity. In this structure, nitrogen atoms can participate in the formation of hydrogen bonds and have a certain solubility in polar solvents.
In terms of chemical properties, its nitrogen atom has lone pairs of electrons, is basic, and can form salts with acids. And the conjugated system allows it to participate in the electrophilic substitution reaction. Because the electron cloud density of the pyridine ring is lower than that of the pyrrole ring, the electrophilic substitution mostly occurs in the pyrrole ring. The existence of 5-methyl affects the reactivity and selectivity, increases the steric resistance, and changes the electron cloud distribution. Under appropriate conditions, methyl groups can undergo oxidation, substitution and other reactions.
In addition, the compound can be used as an intermediate in organic synthesis for the construction of complex nitrogen-containing heterocyclic compounds, with potential applications in pharmaceutical chemistry, materials science and other fields. Its unique chemical properties provide broad space for research and application in related fields.

The common synthesis methods of 1H-pyrrolido [2,3-b] pyridine-5-methyl derivatives are as follows:
First, nitrogen-containing heterocyclic and halogenated hydrocarbons are used as raw materials. In a suitable reaction vessel, put the corresponding nitrogen-containing heterocyclic precursor, such as pyrrolido [2,3-b] pyridine derivative, which must have a suitable activity check point. Complex with halogenated methyl reagents, such as iodomethane, bromomethane, etc. Select appropriate bases, such as potassium carbonate, sodium carbonate, etc., to help the reaction proceed. In an organic solvent, such as N, N-dimethylformamide (DMF), dimethylsulfoxide (DMSO), etc., the reaction is stirred at a certain temperature. This reaction involves the mechanism of nucleophilic substitution. The halogen atom of the halogenated hydrocarbon leaves, and the methyl group is substituted to a specific position of the nitrogen-containing heterocycle to form the target product 1H-pyrrolido [2,3-b] pyridine-5-methyl derivative.
Second, the coupling reaction catalyzed by transition metals. Take a pyrrolido [2,3-b] pyridine substrate containing a specific substituent, and methylation reagents, such as methyl borate, methyl tin reagents, etc. Using transition metal complexes such as palladium and nickel as catalysts, such as tetra (triphenylphosphine) palladium (0) and the like. And add ligands to enhance the activity and selectivity of metal catalysts. In the presence of suitable bases and organic solvents, at a certain temperature and reaction time, through the coupling process of metal catalysis, the connection of methyl groups to pyrrolido [2,3-b] pyridine substrates is realized, thereby obtaining 1H-pyrrolido [2,3-b] pyridine-5-methyl derivatives.
Third, an intramolecular cyclization strategy. Design a suitable linear precursor molecule, which should contain the structural unit that can construct the pyrrolido [2,3-b] pyridine ring system, and have the potential check point of methylation at the appropriate position. Under acidic or basic conditions, or with the help of specific catalysts, intra-molecular cyclization reactions are initiated. During the reaction, the chemical bonds in the molecule are rearranged and connected, and the methylation step is realized at the same time, and the structure of 1H-pyrrolido [2,3-b] pyridine-5-methyl is constructed in one step. This method requires precise design of the structure of the precursor molecule to ensure that the cyclization reaction can proceed smoothly and the target product can be obtained.

1H-pyrrolido [2,3-b] pyridine-5-methyl is useful in many fields.
In the field of pharmaceutical research and development, it has attracted much attention. Due to its unique structure, it has specific biological activities, or it can be used as a lead compound to help create new drugs. It may act on specific biological targets and have potential efficacy in disease treatment. For example, in tumor treatment research, some compounds containing this structure have been studied, showing the possibility of inhibiting tumor cell growth, or can affect tumor cell proliferation and apoptosis by regulating related signaling pathways, adding new ideas for anti-cancer drug research and development.
In the field of materials science, it also has application potential. For example, it can be used as an organic Light Emitting Diode (OLED) material because of its unique electronic structure, or it can emit light efficiently under the action of an electric field to improve the luminous efficiency and performance of OLED devices; or it can be used in organic semiconductor materials to improve the material carrier transport performance, and can be used in the manufacture of high-performance organic field effect transistors and other electronic devices.
In the field of pesticides, it may also play a role. Because it has a specific mechanism of action on certain pests or microorganisms, it can be developed into a new type of pesticide. It can interfere with the physiological functions of the nervous system and respiratory system of pests, achieving the purpose of pest control; or it can inhibit or kill specific plant pathogens, protect crops from disease infestation, and because of its novel structure, it can reduce the problem of traditional pesticide resistance, providing assistance for the sustainable development of agriculture.

Today there is 1H - pyrrolo [2,3 - b] pyridine, 5 - methyl -, which is the name of an organic compound. Its market prospect is related to many aspects.
Look at the field in which this compound is located, or involves pharmaceutical research and development, materials science, etc. In the field of pharmaceutical research and development, if this compound has unique biological activity, can act on specific targets, or can become a key raw material for the creation of new drugs. In today's society, human beings are unremitting in their pursuit of health, and the pharmaceutical market demand is ever-thriving. If innovative drugs based on this can be developed to cure intractable diseases, they will gain a broad market. Pharmaceutical companies must compete and invest resources in in-depth development, and their market prospects will be bright.
In the field of materials science, if this compound has special physical and chemical properties, such as excellent optical and electrical properties, it may be applied to the preparation of new materials. With the advancement of science and technology, the demand for high-performance materials in electronic equipment, optical instruments and other fields is increasing. If it can be successfully applied to related materials to meet the needs of industrial upgrading, the market will also open the door.
However, its market prospects are also facing challenges. Synthesis of this compound may have technical problems, and production costs may remain high. If costs cannot be effectively reduced, it may be difficult to gain an advantage in market competition. And the road to new drug research and development is long, and it requires rigorous clinical trials, which is quite risky. Material application also needs to overcome many technical barriers to meet actual production and application requirements.
In summary, if 1H-pyrrolo [2,3-b] pyridine, 5-methyl-can break through technical bottlenecks and solve cost problems, it will have considerable market prospects in fields such as medicine and materials; otherwise, it may be trapped in development and the prospects are uncertain.

The physical properties of 1H-pyrrolido [2,3-b] pyridine, 5-methyl-pyridine are also quite important, and are related to its behavior in various situations. Its shape may be solid, often with a specific color, or white or yellowish, depending on its purity and preparation method.
Its melting point is also one of the key physical properties. Generally speaking, the melting point of 5-methyl-1H-pyrrolido [2,3-b] pyridine is in a certain temperature range. If you want to know it for sure, it needs to be determined by precise experiments. The melting point is determined by intermolecular forces, such as hydrogen bonds, van der Waals forces, etc. The structure of the molecule, the presence of 5-methyl, affects the way the molecule is stacked, and then the melting point is left and right.
Furthermore, the solubility of this substance cannot be ignored. In organic solvents, such as common ethanol, dichloromethane, etc., it may exhibit different degrees of solubility. In polar organic solvents, due to the interaction between molecular polarity and solvent polarity, there may be good solubility; however, in non-polar solvents, solubility may be poor. This characteristic is due to its molecular structure containing nitrogen heterocycles and methyl groups, which have certain polarity.
Its density is also a physical property. Although the exact value needs to be measured experimentally, its density is related to the molecular weight and the degree of intermolecular arrangement. From its structure, it can be seen that the relative molecular mass changes due to the addition of methyl groups, and the molecular arrangement is also affected by it, which ultimately affects the density.
In addition, the volatility of this compound also belongs to the category of physical properties. Volatility is related to the intermolecular force and boiling point. Due to the different size of the intermolecular force, the boiling point is different, which determines the volatility strength. The volatility of 5-methyl-1H-pyrrolido [2,3-b] pyridine may vary according to specific conditions, such as temperature, pressure, etc.