1H-Pyrrolo[2,3-b]pyridine, 5-bromo-

The main application fields of 1H-pyrrolido [2,3-b] pyridine and 5-bromine are very important in medicinal chemistry, materials science and organic synthesis.
In the field of medicinal chemistry, this compound is often used as a key intermediate to create various biologically active drug molecules. Because of its special chemical structure, it can interact with specific targets in organisms, so it plays an important role in the development of many drugs such as anti-tumor, anti-virus, and antibacterial. For example, the design of some new anti-tumor drugs is based on 1H-pyrrolido [2,3-b] pyridine, 5-bromine, which has been modified and optimized to improve their targeting and inhibitory effect on tumor cells.
In the field of materials science, 1H-pyrrolido [2,3-b] pyridine, 5-bromine can be used to prepare functional materials. Due to its unique electronic and optical properties, it can be applied to optoelectronic devices such as organic Light Emitting Diodes (OLEDs) and organic photovoltaic cells. Materials made from it may exhibit excellent luminous efficiency, stability and charge transport properties, thereby enhancing the overall efficiency of optoelectronic devices.
In the field of organic synthesis, 1H-pyrrolido [2,3-b] pyridine, 5-bromine are extremely useful synthetic building blocks. With its active reaction check point, it can construct complex organic molecules through various chemical reactions, such as nucleophilic substitution and coupling reactions. Organic chemists can use this to expand the structural diversity of compounds, provide an effective way for the creation of new substances, and promote the sustainable development of organic synthetic chemistry.

The synthesis method of 1H-pyrrolido [2,3-b] pyridine, 5-bromo-is mostly based on various organic reactions.
First take the pyridine derivative, and use the halogenation method to make the bromine atom properly substituted. This is a key step. In a suitable reaction vessel, place a pyridine substrate, an appropriate amount of brominating reagents, such as bromine, N-bromosuccinimide (NBS), accompanied by a suitable catalyst, such as Lewis acid, at a suitable temperature and reaction time, stir the reaction. After the reaction is completed, the bromine-containing pyridine intermediate is obtained by separation and purification. < Br >
Then, react with pyrrole derivatives containing active hydrogen. Select pyridine intermediates and pyrrole derivatives, place them in organic solvents, such as dichloromethane, tetrahydrofuran, and add alkali reagents, such as potassium carbonate, triethylamine, etc., to adjust the pH of the reaction system and promote nucleophilic substitution. During the reaction, the temperature is strictly controlled to make the reaction proceed smoothly. After several times of reaction, the product gradually emerges.
Compound by refining to remove its impurities. Column chromatography is commonly used to select suitable silica gel and eluent, and separate them according to the polarity of the product and impurities, so as to obtain pure 1H-pyrrolido [2,3-b] pyridine, 5-bromo-target products. Transition metal catalysis is also used to optimize the synthesis path and improve the yield and selectivity. Metal catalysts such as palladium and copper are used to coordinate ligands to make the reaction more efficient. However, this law requires precise control of the reaction conditions to achieve the desired effect.

The physicochemical properties of 1H-pyrrolido [2,3-b] pyridine, 5-bromine are related to the physical and chemical properties of this compound. This physical property, at room temperature, is either a solid, looking at its appearance, or in the shape of a white to light yellow crystalline powder, which is due to the characteristics of its molecular structure. Its melting point is also an important physical property. It has been experimentally determined, or it is in a specific temperature range. This is determined by the intermolecular force. The strength of the intermolecular interaction determines the energy required for it to change from a solid state to a liquid state, that is, the melting point. Furthermore, its solubility is also the key to physical properties. It may have a certain solubility in organic solvents such as ethanol and dichloromethane. Due to the principle of "similar miscibility", its molecular structure has a polar or non-polar part similar to that of organic solvent molecules, so it can be soluble.
As for chemical properties, the presence of bromine atoms in this compound endows it with active chemical properties. Bromine atoms have strong electronegativity, which can cause changes in the density of electron clouds in the ortho and para-sites, making the benzene ring more prone to electrophilic substitution reactions. If they meet with electrophilic reagents, the ortho or para-carbon atoms of bromine atoms are vulnerable to electrophilic attack and form new replacement products. At the same time, pyridine rings are also alkaline and can react with acids to form salt compounds. This is because the nitrogen atom in the pyridine ring has a lone pair of electrons, which can accept protons and is alkaline. And because of the existence of the conjugate system, the whole molecule has a certain stability, but it also lays the foundation for its participation in various chemical reactions. Under appropriate conditions, many reactions such as addition, oxidation and reduction can occur, showing rich chemical activities.

1H-pyrrolido [2,3-b] pyridine, 5-bromine is in the market, and its price is variable, due to many reasons.
When it comes to the quality of the material, the superior is expensive, and the inferior is slightly cheaper. If its purity is very high, impurities are rare, the preparation process is exquisite, and the labor cost is also more, the price must be high. On the contrary, if the purity is slightly inferior, the process is simple, the price may be slightly lower.
Furthermore, the trend of supply and demand affects its price. If there are many people in the market, but there are few products, and the supply exceeds the demand, the price will rise; if the supply exceeds the demand, the merchant will sell the goods quickly, and the price may drop.
The difficulty of preparation is complex. If the preparation method is complicated, the raw materials are rare, the required utensils and medicines are rare, and the price must be high; if the preparation is easy and the raw materials are widely available, the price may be close to the people.
In addition, the difference between time and place also has an impact. At different times, due to changes in policies, climate, and economy, prices may fluctuate; in different places, due to differences in taxes, freight, and market preferences, prices also vary.
Generally speaking, the price of this 1H-pyrrolido [2,3-b] pyridine, 5-bromine product varies from tens of gold to hundreds of gold per gram in the market, and it is difficult to determine its fixed price. It needs to be observed in real time depending on the above reasons.

There are many patents related to 1H-pyrrolido [2,3-b] pyridine, 5-bromine, because the compound has a wide range of uses in medicine, materials and other fields. The following is a brief description of the relevant patents.
In the field of pharmaceutical research and development, many patents focus on it as a pharmaceutical active ingredient. Due to its unique chemical structure, it can be closely bound to specific biological targets, and has the potential to be developed into drugs for the treatment of various diseases. There are patent reports that by modifying the structure of 1H-pyrrolido [2,3-b] pyridine, 5-bromine, a compound with significant inhibitory activity on a certain type of tumor cells has been successfully obtained, opening up a new path for the development of anti-cancer drugs. This patent describes the compound synthesis method, pharmacological activity testing process and results in detail, providing an important reference for subsequent related drug development.
There are also many related patents in the field of materials science. 1H-pyrrolido [2,3-b] pyridine, 5-bromine can be introduced into polymer materials through specific reactions to endow the materials with special photoelectric properties. For example, there are patents showing the preparation of new organic Light Emitting Diode materials with this compound as a structural unit. The material has high luminous efficiency and good stability, which is expected to improve the performance of organic Light Emitting Diode display technology and promote the development of the display field.
In terms of synthesis methods, many patents are dedicated to the development of more efficient and green synthesis routes. The traditional synthesis of 1H-pyrrolido [2,3-b] pyridine, 5-bromine method or cumbersome steps, low yield, environmental pollution and other drawbacks. The new patent explores the use of new catalysts and green solvents to optimize the reaction conditions, realize a more convenient, efficient and environmentally friendly synthesis process, greatly reduce production costs, improve the production efficiency and quality of the compound, and is of great significance to promote its large-scale industrial application.