1H-Pyrrolo[2,3-b]pyridine, 5-(4-chlorophenyl)-

1H-pyrrolido [2,3-b] pyridine, 5- (4-chlorophenyl), its chemical structure is as follows.
This compound has a parent nucleus structure of pyrrolido [2,3-b] pyridine. The part of pyrrolido pyridine is formed by fusing a pyrrole ring with a pyridine ring, and the two rings share two adjacent carbon atoms, forming a unique fused ring system.
At the 5th position of the parent nucleus, a substituent, namely 4-chlorophenyl, is connected. This 4-chlorophenyl group is composed of a benzene ring, which is connected with a chlorine atom at the 4th position of the benzene ring (calculated as the carbon atom of the benzene ring connected to the parent nucleus of pyrrolido-pyridine).
Its overall chemical structure fuses the heterocyclic properties of pyrrolido-pyridine and the aromatic properties of 4-chlorophenyl. The presence of nitrogen atoms endows the molecule with a certain electron cloud distribution and chemical activity. The introduction of 4-chlorophenyl not only increases the steric resistance of the molecule, but also affects the electron density of the molecule due to the electronegativity of the chlorine atom, which in turn has a significant impact on the physical, chemical and biological activities of the compound.

5- (4-chlorophenyl) -1H-pyrrolido [2,3-b] pyridine, the physical properties of this substance are as follows:
Looking at its shape, under normal conditions, or in a solid state, it is mostly powdery, fine like dust and smoke, uniform and delicate. Its color is often white to off-white, pure and simple, just like the purity of first snow, and like the color of new cotton.
When it comes to melting point, it is about a certain temperature range. This value is its inherent characteristic, just like a human endowment, depending on the structure. When the outside temperature slowly rises to the melting point, the substance is like ice and snow meeting the warm sun, gradually melting from the solid state to the liquid state, and the binding force between the molecules gradually weakens and begins to flow freely.
As for solubility, it may have different behaviors in many common organic solvents. In some organic solvents, such as alcohols, there is a certain solubility, just like fish entering water, some molecules can be evenly dispersed; in the aqueous phase, the solubility is poor, just like the incompatibility of oil and water. Due to the characteristics of molecular structure, it is difficult to form an effective interaction with water molecules.
Its density is also one of the important physical properties. Although there is no exact value, it can be known that it is an inherent property of the substance, which reflects the mass of the substance contained in the unit volume and is closely related to the accumulation of molecules.
The physical properties of this substance are of great significance in the fields of chemical industry and pharmaceutical research and development. In chemical production, rational preparation and purification processes can be designed according to its solubility, melting point and other properties; in pharmaceutical research and development, these properties are closely related to the absorption, distribution, metabolism and other processes of drugs, and are related to whether new drugs can be successfully developed and treat diseases and save lives.

1H-pyrrolido [2,3-b] pyridine-5- (4-chlorophenyl) has a wide range of uses. In the field of pharmaceutical research and development, it is often used as a key intermediate. Due to its unique molecular structure, it can be ingeniously chemically modified to obtain compounds with specific pharmacological activities, and then used in the treatment of various diseases, such as the development of anti-tumor drugs. In the process of tumor cell growth and proliferation, this compound may play an intervention role, providing a new opportunity to overcome tumor problems.
In the field of materials science, it also shows potential value. Its structural properties give materials other physical and chemical properties, such as affecting the electrical and optical properties of materials. Scientists can use this to develop new organic electronic materials, such as organic Light Emitting Diodes (OLEDs), solar cells, etc., to improve the performance and efficiency of such devices.
Furthermore, in the creation of pesticides, it can be used as a lead compound. After rational structure optimization, high-efficiency, low-toxicity and environmentally friendly pesticide varieties may be derived, which is of great significance to agricultural sustainable development.

To prepare 5- (4-chlorophenyl) -1H-pyrrolido [2,3-b] pyridine, there are many methods, and now Chen is the first one.
First take appropriate starting materials, such as compounds containing pyridine and pyrrole structures, and use them as groups to find a suitable reaction path. 4-chlorophenyl is often introduced by halogenated aromatics. Choose 4-chlorophenyl halide, such as 4-chlorobromobenzene, to react with pyridine-pyrrole intermediates containing active check points. This reaction requires suitable bases, such as potassium carbonate, sodium carbonate, etc., to promote the reaction. In an organic solution, such as N, N-dimethylformamide (DMF), dichloromethane, etc., heat and stir to make the reactants fully contact and achieve the purpose of substitution reaction.
When reacting, pay attention to the control of reaction conditions. The temperature should not be too high or too low. If it is too high, side reactions will occur, and if it is too low, the reaction will be slow or not occur. Use a temperature control device to adjust to a suitable temperature range, such as 60-100 degrees Celsius. At the same time, the reaction time is also critical, and it needs to be monitored according to the reaction process. Thin-layer chromatography (TLC) can be used to observe the consumption of raw materials and the formation of products.
After the reaction is completed, the separation and purification It is commonly used in column chromatography, select a suitable silica gel column, and rinse with eluents of different polarities to obtain pure 5- (4-chlorophenyl) -1H-pyrrolido [2,3-b] pyridine. Recrystallization can also be used to select a suitable solvent to dissolve the product and recrystallize it to remove impurities to obtain a pure product.
This is a method for preparing 5- (4-chlorophenyl) -1H-pyrrolido [2,3-b] pyridine. When implemented, it can be optimized according to the situation to achieve better results.

1H-pyrrolido [2,3-b] pyridine, 5 - (4-chlorophenyl) This substance is a matter of safety and must be cautious. When handling this chemical substance, it is essential to protect it. First of all, make sure that the space is well ventilated to prevent the accumulation of harmful gas and endanger the human body. Operators must wear appropriate protective equipment, such as a gas mask, which can prevent harmful particles from entering the body; wear protective gloves to prevent skin contact with it and erosion; wear protective clothing to fully protect their body.
Furthermore, when storing, also pay attention. It should be placed in a cool, dry and ventilated place, away from fire and heat sources, to prevent accidents. It needs to be placed separately from oxidizing agents, acids and other substances. Due to its active chemical properties, if it is improperly mixed with other substances, it may cause violent reactions and cause disasters.
During use, operate with precision and strictly abide by the procedures. Do not change the operation method without authorization to avoid danger. After use, properly dispose of the remaining objects and utensils used. Do not discard at will. In accordance with relevant regulations, properly dispose of the method to avoid polluting the environment and harming the four parties.
All substances involved in this chemical should be treated with awe, carefully observe their properties, and strictly abide by safety regulations, so as to ensure safety and everything goes smoothly.