1H-pyrrolo[2,3-B]pyridine, 4-Chloro-

The physical properties of 1H-pyrrolido [2,3-B] pyridine, 4-fluorine are as follows:
The appearance of this compound is often a crystalline solid. Its melting point is crucial for identification and purification, but the specific value varies depending on the synthesis and purification method. Generally speaking, the transition from solid state to liquid state occurs within a certain temperature range.
The boiling point is also an important physical property. The boiling point reflects the strength of intermolecular forces and is significantly affected by the structure of the compound. However, the exact boiling point data also needs to be determined experimentally, which will fluctuate due to different conditions.
The density is related to the unit volume mass and is of great significance when studying its behavior in different media. Its density also varies depending on the measurement conditions.
In terms of solubility, the compound may exhibit certain solubility properties in common organic solvents such as dichloromethane, N, N-dimethylformamide (DMF), etc. In dichloromethane, it may interact with the solute-solvent according to temperature, showing partial or complete solubility. In water, due to its structure containing nitrogen heterocycles and fluorine atoms, the polarity is not exactly matched with water molecules, so the solubility is poor.
In addition, the refractive index of 1H-pyrrolido [2,3-B] pyridine and 4-fluorine can reflect the degree of change in the direction of light passing through the substance, which is closely related to the molecular structure. It may have application value in the fields of optics and analysis. < Br >
Its physical properties are the key basis for studying the chemical behavior of the compound, participating reaction conditions and application scenarios.

The chemical properties of 1H-pyrrolido [2,3-B] pyridine, 4-chlorine are as follows:
This compound contains a nitrogen heterocyclic structure and exhibits a certain alkalinity. Because the nitrogen atom has a lone pair of electrons, it can accept protons. In acid, the nitrogen atom easily combines with the proton to form the corresponding salt.
Its nucleophilic substitution reaction activity is quite high. 4-chlorine atom is a good leaving group and is easily replaced when encountering nucleophilic reagents. For example, when it encounters sodium alcohol, the chlorine atom will be replaced by an alkoxy group to form an ether product; when it reacts with amines, the chlorine atom will be replaced by an amino group to obtain a nitrogen-containing derivative.
The compound can also perform electrophilic substitution reactions. In view of the fact that the pyrrolidine ring system is rich in electrons, it is attractive to electrophilic reagents. Generally speaking, the reaction occurs at a position with a higher electron cloud density. For example, under suitable conditions, halogenation reactions occur with halogenating reagents, introducing halogen atoms on the ring; reactions with acylating reagents achieve acylation.
In addition, it has certain redox properties. Under the action of a specific oxidant, some atoms on the ring may be oxidized; and in the presence of suitable reducing agents, a reduction reaction can occur, which can change the molecular structure.
At the same time, due to the presence of conjugated systems in the molecule, this compound absorbs in the ultraviolet-visible region, and can be analyzed and identified by spectroscopy. It is widely used in organic synthesis, medicinal chemistry, and other fields. It is often used as a key intermediate to prepare various functional compounds and drugs.

The common use of 1H-pyrrolido [2,3-B] pyridine and 4-chlorine has important applications in many fields such as medicinal chemistry and materials science.
In medicinal chemistry, this compound is often a key intermediate for the synthesis of many biologically active drug molecules. Due to its unique chemical structure, it can interact with specific targets in organisms. For example, some drugs synthesized based on this can act on cell signaling pathways and be beneficial in the treatment of certain diseases such as tumors and inflammation. By precisely modifying its structure, the activity, selectivity and pharmacokinetic properties of the drug can be adjusted, thereby improving the efficacy of the drug and reducing side effects.
In the field of materials science, 1H-pyrrolido [2,3-B] pyridine, 4-chlorine can be used to prepare functional organic materials. Due to its special electronic structure and optical properties, it can be applied to the fabrication of organic Light Emitting Diodes (OLEDs), organic solar cells and other devices. In OLEDs, it can be used as a luminescent material or electron transport material to improve the luminous efficiency and stability of devices; in organic solar cells, it helps to improve the light absorption and charge transfer efficiency, thereby improving the photoelectric conversion efficiency of batteries.
In addition, in the field of organic synthetic chemistry, this compound is often used as an important building block, participating in the construction of various complex organic molecules. With its active reaction check point, it can combine with other organic fragments through various chemical reactions, such as nucleophilic substitution, coupling reaction, etc., to expand the structural diversity of organic molecules and provide a basis for the creation of new compounds.

The synthesis method of 1H-pyrrolido [2,3-B] pyridine, 4-halogen is an important research direction in the field of organic synthesis. According to the ancient narrative of "Tiangong Kaiwu", the synthesis method is described.
Synthesis of this compound, one of the methods is to use nitrogen-containing heterocycles as starting materials and introduce halogen atoms by nucleophilic substitution reaction. In previous methods, suitable halogenated reagents, such as halogenated sulfoxide and phosphorus halide, were often selected to react with nitrogen-containing heterocycles at suitable temperatures and solvents. This reaction requires fine regulation of the reaction conditions. Due to the high activity of halogenated reagents, it is easy to cause side reactions. If the temperature is too high, or the halogenation is excessive; if the temperature is too low, the reaction will be slow and the yield will be poor.
Furthermore, it can be formed by a metal-catalyzed coupling reaction. Transition metal catalysts, such as palladium and nickel, are often used in synergy with ligands to couple halogenated aromatics to nitrogen-containing heterocyclic substrates. In this process, the metal catalyst activates the substrate, causing the carbon-halogen bond to break, and then forms a new carbon-nitrogen bond with the nitrogen-containing heterocyclic ring. However, this method requires strict catalyst requirements, and the choice of catalyst, the dosage and the purity of the reaction system all have a significant impact on the reaction effect.
Another strategy is to introduce halogen atoms synchronously by constructing pyrrolido [2,3-B] pyridine parent nuclei. First, the parent nucleus structure is constructed by cyclization with appropriate raw materials. During the reaction process, the reaction steps are cleverly designed to embed the halogen atoms in the target position when cyclization occurs. This method needs to be well understood about the reaction mechanism in order to accurately control the reaction process and improve the selectivity and yield of the target product.
There are many synthesis methods, each with advantages and disadvantages. It is necessary to carefully choose according to actual needs, such as product purity, cost, difficulty of reaction conditions, etc., in order to achieve the best synthesis effect.

I look at your question, it is about the price range of 1H-pyrrole [2,3-B] pyridine, 4-halogen-this substance in the market. However, the price of this chemical is difficult to generalize, and it is also subject to many factors.
The first to bear the brunt is the type of halogen atom. If it is fluorine, its synthesis process may be more complicated, and the raw materials may be rare, so the price should be higher; if it is chlorine, the process may be relatively simple, and the raw materials are easily available, the price may be slightly lower; bromine and iodine, each due to its characteristics, also vary in price.
Furthermore, purity has a great impact. For high purity, the preparation requires finer processes and steps, the cost is greatly increased, and the price is high; for low purity, although the preparation is easier, the application is limited, and the price is also low.
Market supply and demand are also key. If there is a large increase in demand for this product at a certain time, and the supply is limited, the merchant will raise the price; on the contrary, if there is an excess supply and the demand is small, the price will drop.
In addition, the difference between manufacturers and regions will also lead to different prices. Different manufacturers have different technologies and costs, and transportation costs and market competition in various places make the price fluctuate.
Roughly speaking, the price of such chemicals ranges from a few yuan to several hundred yuan per gram. If it is a common halogen and the purity is average, it may cost a few to tens of yuan per gram; if it is a special halogen and high purity, it may cost hundreds or even hundreds of yuan per gram. However, this is only a rough estimate. For the exact price, you need to consult the chemical product supplier in detail, subject to the real-time market conditions.