1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid, 6-chloro-, ethyl ester

1H-pyrrolido [2,3-b] pyridine-2-carboxylic acid, 6-chloro-ethyl ester, the physical properties of this substance are as follows.
Its appearance is often white to off-white crystalline powder, which is determined by its molecular structure arrangement and interaction. In terms of solubility, it has a certain solubility in organic solvents such as dichloromethane, N, N-dimethylformamide. This characteristic is due to the interaction force between polar groups in the molecule and the organic solvent molecules, which can make the molecules uniformly disperse. However, its solubility in water is low, because the hydrophobic part of the compound accounts for a large proportion, and it is difficult to form an effective interaction with water molecules. The melting point of
is in a specific range, which is roughly between [X] ° C and [X] ° C. As one of the important physical properties of a substance, the melting point is closely related to the intermolecular forces. The strength of the interaction between the molecules of this compound, such as Van der Waals force and hydrogen bonds, determines its melting point value. The density of
is also a key physical property, which is about [X] g/cm ³, which reflects the mass of the substance in a unit volume and is related to the degree of tight packing of molecules and the relative mass of atoms.
The stability of this compound is good at room temperature and pressure, but care should be taken to avoid contact with strong oxidants, strong acids, strong bases and other substances, because some chemical bonds in its structure may break or react under specific chemical environments, thereby changing its chemical structure and physical properties. This stability is based on the analysis of the bond energies and reactivity check points of various chemical bonds in its molecular structure.

The synthesis method of 6-chloro-1H-pyrrolido [2,3-b] pyridine-2-carboxylate ethyl ester follows the following path.
First, a suitable pyridine derivative is used as the starting material. The chlorine atom is introduced at a specific position of the pyridine ring first, which can be achieved by halogenation reaction. Appropriate halogenating reagents, such as chlorine-containing halogenating agents, are selected to achieve precise substitution of chlorine atoms under appropriate reaction conditions, such as the presence of specific temperatures, solvents and catalysts. This step requires fine regulation of the reaction conditions to ensure that the chlorine atom is connected at the desired 6 positions.
Then, the pyrrole ring structure is constructed. Condensation reactions are often used to select reagents containing suitable functional groups to react with halogenated pyridine derivatives. Such reagents usually have activity check points that can be condensed with specific groups of the pyridine ring, and go through the process of intramolecular cyclization to construct pyrrolido [2,3-b] pyridine parent nuclei. During the reaction process, solvent properties, temperature, and reaction time are all key factors, which need to be carefully controlled to make the reaction proceed in the desired direction.
Wait for the parent nucleus to form, and then perform carboxylic acid ethyl esterification reaction. Using carboxyl reagents, react with alcohols (this is ethanol) under the action of esterification reagents. Common esterification reagents such as concentrated sulfuric acid or specific dehydrating agents promote the condensation of carboxyl groups with alcohol hydroxyl groups to form the target product 6-chloro-1H-pyrrolio [2,3-b] pyridine-2-carboxylic acid ethyl ester. In this step, attention should be paid to the reversibility of the reaction, or measures should be taken to remove the water generated by the reaction to promote the positive progress of the reaction and improve the yield of the product.
Second, pyrrole derivatives are also used as starting materials. First, the pyrrole ring is modified, the structure fragment of the pyridine ring is introduced, and then the target compound is obtained through a series of reactions such as halogenation and esterification. The reaction conditions of each step in this path also need to be carefully optimized and adjusted according to the characteristics of the substrate and the properties of the reagents used, etc., in order to synthesize 6-chloro-1H-pyrrolido [2,3-b] pyridine-2-carboxylic acid ethyl ester with high efficiency and high purity.

Ethyl 6-chloro-1H-pyrrolido [2,3-b] pyridine-2-carboxylate has a wide range of uses. In the field of medicinal chemistry, it is often a key intermediate in the synthesis of many drugs. Due to its specific chemical structure and activity, compounds with specific pharmacological activities can be constructed through a series of chemical reactions, and then therapeutic drugs for specific diseases can be developed, or in the modification of drug molecules, the pharmacokinetic properties of drugs can be improved, such as improving bioavailability and enhancing stability.
In the field of organic synthesis chemistry, it is an important starting material for the construction of complex organic molecules. With its various active functional groups, it can participate in various classical organic reactions, such as nucleophilic substitution, electrophilic addition, etc., to prepare organic materials with novel structures and unique functions, or to synthesize substances with special optical and electrical properties, playing an important role in the field of materials science.
At the level of scientific research and exploration, researchers often use this material as a basis to carry out various reaction mechanism studies and explore new synthesis methods, contributing to the enrichment and development of theoretical knowledge of organic chemistry, and laying the foundation for the synthesis and application of more novel compounds in the future.

I don't know the price range of "1H - pyrrolo [2,3 - b] pyridine - 2 - carboxylic acid, 6 - chloro -, ethyl ester" in the market. The price of various items in the market often varies due to changes in time, place, quality and supply and demand. This compound may be rare or useful in special industries. To know its price, you can go to the chemical raw material market, chemical reagent firm, or consult the chemical product supplier. You can also look at the online chemical product trading platform to get relevant price information. However, the price obtained through these channels is only a reference for a time and place, and it is not constant. And the simplicity of its production process and the level of purity can affect its price. Therefore, the exact price range is difficult to determine solely based on the name of this item, and it must be obtained after multiple explorations and comparisons.

1H-pyrrolido [2,3-b] pyridine-2-carboxylic acid, 6-chloro-, ethyl ester, the safety and toxicity of this substance are related to human life and cannot be ignored.
Looking at this substance, its chemical structure is unique, but in order to know its safety and toxicity in detail, many complicated experiments and explorations are required. In the laboratory, animals are first tested to observe their various reactions after ingesting this substance. Observe whether their eating, movement, physiological functions, etc. are abnormal. If animals eat it, there are no adverse reactions such as breathing difficulties, convulsions, and malaise, and the physiological state remains the same after several days, it can be preliminarily inferred that its toxicity is weak.
However, only based on this, it is not enough to discuss its safety. It is also necessary to explore its stability in different environments. In case of extreme conditions such as high temperature, strong acid, and strong alkali, if its chemical structure changes, it may form new substances with stronger toxicity. Furthermore, the physiological structures of humans and animals are different, and even if they perform well in animal experiments, it should not be rashly concluded that they are harmless to humans.
In industrial production and daily use scenarios, it is also necessary to consider its impact on the environment. If this substance is released into nature at will, is there any pollution to soil, water sources, air, etc.? If so, what is the degree of pollution? Will it be passed through the food chain layer by layer and eventually endanger human beings?
In summary, in order to determine the safety and toxicity of 1H-pyrrolido [2,3-b] pyridine-2-carboxylic acid, 6-chloro-ethyl ester, it is necessary to conduct in-depth research from multiple aspects and angles, and make prudent judgments. We must not act hastily to avoid endless disasters.