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What is the main use of 1H-pyrazolo [4,3-c] pyridine, 6-bromo -?
1H-pyrazolo [4,3-c] pyrazole, 6-bromo - This substance has a wide range of uses. In the field of medicinal chemistry, it can be used as a key intermediate to assist in the synthesis of drug molecules with specific biological activities. Due to the unique chemical properties of this structure, it can interact with specific targets in organisms, or new antibacterial, anti-inflammatory and even anti-cancer drugs can be developed.
In the field of materials science, compounds containing this structure may exhibit specific optoelectronic properties. Or it can be used to prepare organic Light Emitting Diode (OLED) materials, which can be used to regulate the luminescence properties through their molecular structure to improve luminous efficiency and color purity, and then applied to display technology. Or it can be used as a sensor material to achieve highly sensitive detection of specific components in the environment by virtue of its selective reaction with specific substances.
In the agricultural field, this may be the basis for the development of new pesticides. Because of its targeted inhibition or killing effect on certain pests or pathogens, and compared with traditional pesticides, it may have higher selectivity and lower environmental toxicity, which can effectively protect crop growth and reduce the negative impact on the ecological environment.
What are the physical properties of 1H-pyrazolo [4,3-c] pyridine, 6-bromo-
The physical properties of 1H-pyrazolo [4,3-c] pyrazole, 6-bromine are as follows:
This compound often appears as a crystalline solid in appearance, and forms a regular lattice structure due to the orderly arrangement of atoms in the molecular structure. It exists stably at room temperature and pressure. Its stability is derived from the conjugated structure of pyrazolo-pyrazole rings, which makes the electron cloud distributed uniformly and enhances molecular stability.
In terms of melting point, it is usually in a certain temperature range, and the specific value varies due to purity and other factors. Interactions such as van der Waals forces and hydrogen bonds exist between molecules. It is necessary to absorb enough energy to overcome these effects before the lattice can disintegrate and the substance can melt.
Solubility, slightly soluble in water. Due to the hydrophobicity of the molecule as a whole, the pyrazole-pyrazole ring and the non-polar part of the bromine atom account for a large proportion, and the ability to form hydrogen bonds with water molecules is weak. As a polar solvent, water has limited solubility. However, it is soluble in some organic solvents, such as dichloromethane, chloroform, N, N-dimethylformamide (DMF), etc. In non-polar or weakly polar organic solvents such as dichloromethane, the van der Waals force between the molecule and the solvent is conducive to its dispersion and dissolution; in polar organic solvents such as DMF, although the overall hydrophobicity, the polar part can form a weak interaction with DMF to promote its dissolution. < Br >
The density is related to the relative molecular weight and the degree of molecular packing. Due to the structure of the pyrazole-pyrazole ring system and the existence of bromine atoms, the relative density is higher. The atomic weight of bromine atoms is larger, which increases the molecular weight, and the molecular structure is relatively tightly packed, which increases the mass per unit volume.
1H-pyrazolo [4,3-c] pyrazole, 6-bromine has specific physical properties, which are determined by its molecular structure. In the fields of chemical synthesis, drug research and development, it is of great significance for its separation, purification, and application.
What are the chemical properties of 1H-pyrazolo [4,3-c] pyridine, 6-bromo
1H-pyrazolo [4,3-c] pyrazole, 6-bromo-This material property is particularly important, related to its performance in various reactions, and also involves the wide range of its uses.
When it comes to physical properties, 1H-pyrazolo [4,3-c] pyrazole, 6-bromo are often in the shape of a solid state, and their color is either white or yellowish. Its melting point and boiling point have specific values due to molecular interactions. These parameters are key indicators in the process of separation and purification. Its solubility also has characteristics. In common organic solvents such as ethanol and dichloromethane, the degree of solubility varies, which is determined by the interaction between the polarity of its molecules and the polarity of the solvent.
As for chemical properties, it has unique reactivity due to its pyrazole structure. The presence of 6-bromine adds to the diversity of its reactions. Bromine atoms can be used as good leaving groups for nucleophilic substitution reactions. When encountering nucleophilic reagents, substitution can occur and new functional groups can be introduced. This is an important means for building complex structures in the process of organic synthesis. At the same time, nitrogen atoms on pyrazole rings, with solitary pairs of electrons, can act as nucleophilic check points and react with electrophilic reagents to derive various derivatives. And it also has unique performance in oxidation and reduction reactions, and can generate different products according to different reaction conditions. Such chemical properties make 1H-pyrazolo [4,3-c] pyrazole, 6-bromine have potential application value in medicine, pesticides and other fields, and can provide key structural units for the creation of novel active compounds.
What is the synthesis method of 1H-pyrazolo [4,3-c] pyridine, 6-bromo-
The synthesis method of 1H-indazolo [4,3-c] indazole, 6-bromo-is quite complicated and can only be obtained through multi-step reaction.
The first step is to carry out a condensation reaction with suitable starting materials, such as phenylhydrazine compounds containing specific substituents, and corresponding carbonyl compounds under suitable reaction conditions. This reaction may be carried out by heating in an organic solvent under the catalysis of an acid or a base to form a preliminary cyclic structure. In this process, the choice of solvent is crucial, such as ethanol, toluene, etc., which can be selected according to the characteristics of the reaction substrate. The type and amount of catalyst also have a significant impact on the reaction rate and yield.
Next, the obtained intermediate needs to undergo a further functional group transformation. If you want to introduce bromine atoms at the 6-position, you can choose a suitable bromination reagent, such as N-bromosuccinimide (NBS). During the reaction, care should be taken to control the reaction temperature and time to prevent excessive bromination. This bromination reaction is often carried out in a suitable solvent such as dichloromethane under the protection of inert gases.
Then, the obtained product may need to be purified by recrystallization, column chromatography, etc., to obtain a high-purity 1H-indazolo [4,3-c] indazole, 6-bromo-target product. During recrystallization, a suitable solvent needs to be selected to dissolve the product at high temperature and precipitate at low temperature; column chromatography needs to select suitable fixed and mobile phases according to the polarity difference between the product and the impurity to achieve effective separation.
Each step of the reaction requires fine regulation of the reaction conditions, and also requires the purity of the raw materials and the cleanliness of the reaction equipment. In this way, it is expected to synthesize 1H-indazolo [4,3-c] indazolo, 6-bromo-with higher yield and purity.
1H-pyrazolo [4,3-c] pyridine, 6-bromo - in which fields is it used?
1H-pyrazolo [4,3-c] pyrazole, 6-bromo This substance has important applications in the fields of medicine, materials science and organic synthesis.
In the field of medicine, it is often a key intermediate to create new drugs. Due to its unique chemical structure, it can precisely fit with specific targets in organisms and has good biological activity and pharmacological properties. For example, in the research and development of anti-tumor drugs, this structure can be modified to optimize its targeting and inhibitory ability on tumor cells, interfere with tumor cell growth, proliferation and metastasis related signaling pathways, and provide new opportunities for conquering cancer; in the field of antibacterial drugs, its structural advantages can be used to design compounds that have strong inhibitory effects on specific pathogens, destroy bacterial cell walls, cell membranes or interfere with bacterial metabolic processes, thus effectively fighting bacterial infections.
In the field of materials science, 1H-pyrazolo [4,3-c] pyrazole, 6-bromo derivatives exhibit unique photoelectric properties. It can be used to prepare organic Light Emitting Diode (OLED) materials. With its structure, the luminous color and efficiency can be adjusted, the OLED display effect can be improved, and the screen color is brighter and the contrast ratio is higher. In terms of solar cell materials, it can improve the absorption and charge transfer efficiency of the material through rational design, improve the photoelectric conversion efficiency of the solar cell, and contribute to the development of renewable energy.
In the field of organic synthesis, it is an extremely useful synthetic block. Because of its rich reaction check points, complex organic molecular structures can be constructed through various chemical reactions, such as nucleophilic substitution and coupling reactions. Organic chemists can use this to design and synthesize organic compounds with specific functions and structures, providing powerful tools for the study of new functional materials, total synthesis of natural products, etc., greatly expanding the boundaries of organic synthetic chemistry, and helping to create more organic compounds with novel structures and unique properties.