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What is the main application field of 1H-Pyrazolo [4,3-c] pyridine, 4,5,6, 7-tetrahydro-1-phenyl-
The main application fields of 1H-pyrazolo [4,3-c] pyridine, 4,5,6,7-tetrahydro-1-phenyl-this substance are related to many aspects. In the field of pharmaceutical research and development, it may have unique effects. Due to its special structure, it can be used as a potential drug molecule for the exploration of therapeutic agents for specific diseases. Such as some difficult diseases, traditional drugs have poor efficacy, and based on this substance, through ingenious modification and research, new specific drugs may be created, bringing good news to patients.
In the field of organic synthetic chemistry, it is also a key intermediate. Chemists can use various reactions to construct more complex and functional organic molecules. With it as a starting material, through carefully designed reaction routes, novel compounds can be synthesized, providing a new material basis for materials science and other fields.
In the field of materials science, if it is reasonably introduced into the material structure, or endowed with special properties. Such as optical properties, electrical properties, etc., and then develop advanced materials suitable for specific scenarios, such as new optoelectronic materials, which may have outstanding performance in electronic display, optoelectronic device manufacturing, etc.
Furthermore, in the field of biological activity research, it can be used to explore the mechanism of action of specific targets in organisms. With the interaction with biological macromolecules, in-depth understanding of physiological and pathological processes in organisms provides important clues and tools for life science research. In conclusion, 1H-pyrazolo [4,3-c] pyridine, 4,5,6,7-tetrahydro-1-phenyl-has shown potential and important application value in the fields of medicine, organic synthesis, materials science and biological activity research.
What are the synthesis methods of 1H-Pyrazolo [4,3-c] pyridine, 4,5,6, 7-tetrahydro-1-phenyl-
The synthesis method of 1H-pyrazolo [4,3-c] pyridine, 4,5,6,7-tetrahydro-1-phenyl-can follow the following path:
Starting with suitable pyridine derivatives as raw materials, this is the starting material of synthesis. Under specific reaction conditions, it interacts with the reagent containing the pyrazole structure. Or it can be heated and accompanied with a suitable catalyst to promote the condensation reaction of the pyridine ring and the pyrazole ring to construct the basic skeleton of 1H-pyrazolo [4,3-c] pyridine.
Furthermore, in order to introduce the structural characteristics of 4,5,6,7-tetrahydro, the obtained pyrazole-pyridine intermediates can be hydrogenated. Often a metal catalyst, such as palladium carbon or platinum black, is reacted under a hydrogen atmosphere, so that the double bond on the pyridine ring is hydrogenated and saturated, so as to achieve the structural modification of tetrahydro.
As for the introduction of 1-phenyl, a nucleophilic substitution reaction can be used at an appropriate stage. Select a suitable phenyl halide, and in the presence of a base, undergo nucleophilic substitution with the aforementioned reaction products, so that the phenyl group is connected to the 1 position of pyrazole-pyridine. The choice of alkali is crucial, such as potassium carbonate, sodium carbonate and other inorganic bases, which can provide the alkaline environment required for the reaction and help the smooth progress of nucleophilic substitution.
In addition, attention should be paid to the precise control of the reaction conditions during the reaction process. Temperature, reaction time and the proportion of reactants all have a significant impact on the yield and selectivity of the reaction. The appropriate temperature may range from tens of degrees Celsius to hundreds of degrees Celsius, and the reaction time depends on the monitoring of the reaction process, which may take several hours or even tens of hours. The proportion of reactants should also be carefully considered and optimized to ensure that each step of the reaction is advanced efficiently, and the final target product is 1H-pyrazolo [4,3-c] pyridine, 4,5,6,7-tetrahydro-1-phenyl-.
What are the physicochemical properties of 1H-Pyrazolo [4,3-c] pyridine, 4,5,6, 7-tetrahydro-1-phenyl-
The physical and chemical properties of 1H-pyrazolo [4,3-c] pyridine, 4,5,6,7-tetrahydro-1-phenyl-this substance are as follows:
Its appearance or a specific crystalline shape, because the molecular structure contains specific groups and atomic arrangement, resulting in its crystal has a unique lattice structure. Under normal temperature and pressure, it is mostly solid state. This is due to intermolecular forces, such as van der Waals force, hydrogen bonds, etc., which make the molecules closely arranged and maintain the stability of the solid state.
When it comes to melting point, it is experimentally determined that it is often in a specific temperature range. This is because when the temperature rises, the molecule gains energy, the vibration intensifies, and when the energy is sufficient to overcome the intermolecular force, the lattice disintegrates, and the substance changes from solid to liquid. In terms of boiling point, there is also a corresponding value, which is closely related to the relative molecular weight and intermolecular force of the molecule. The larger the relative molecular mass, the stronger the intermolecular force, the more energy required for boiling, and the higher the boiling point.
In terms of solubility, the substance behaves differently in different solvents. In polar solvents, such as water, due to the degree of matching between the polarity of the molecule and the polarity of the water molecule, if the molecule has a polar group or forms a hydrogen bond with water, it has a certain solubility; in non-polar solvents, such as alkanes, due to the difference between the intermolecular force and the intermolecular force of the solvent, the solubility may be extremely low.
Its chemical properties are also interesting. The structure of pyrazole and pyridine in the molecule gives it unique reactivity. The aromatic ring part is aromatic and can undergo electrophilic substitution reactions, such as halogenation, nitrification, sulfonation, etc. Due to the density distribution of the electron cloud of the aromatic ring, the specific position is vulnerable to the attack of electrophilic reagents. The saturated carbon chain of the tetrahydro part is relatively stable, but under specific conditions, such as strong oxidants and high temperatures, oxidation and cracking reactions can also occur. The presence of phenyl groups not only affects the spatial configuration of the molecule, but also has a significant impact on its reactivity and selectivity, often guiding the reaction in a specific direction. In short, the physical and chemical properties of this substance are determined by its molecular structure, and play a key role in many chemical processes and applications.
How does 1H-Pyrazolo [4,3-c] pyridine, 4,5,6, 7-tetrahydro-1-phenyl- look in the market?
Today there is a product named 1H-pyrazolo [4,3-c] pyridine, 4,5,6,7-tetrahydro-1-phenyl. This is an organic compound, but in the market situation, let me elaborate.
Looking at today's market, this compound has a rich application field. In the field of pharmaceutical research and development, because of its unique chemical structure, it can be used as a potential drug intermediate. Doctors and pharmacists hope to use it as a basis to create new agents to cure various diseases, so it is often needed in scientific research institutions and pharmaceutical companies.
Furthermore, in the field of material science, it may have special physical and chemical properties, which can be used to prepare new materials, such as photoelectric materials. Those who study materials also pay close attention to it, so that it is gradually emerging in the relevant market transactions.
However, its market also has challenges. The process of synthesizing this compound may require exquisite technology and specific reagents, and the cost is not light, which may limit its large-scale production and wide application. And similar substitutes also exist in the market, and the state of competition cannot be ignored.
But in general, with the advance of science and technology, the rapid development of medicine and materials industries, 1H-pyrazolo [4,3-c] pyridine, 4,5,6,7-tetrahydro-1-phenyl, with its potential value, the market prospect can still be expected. With time, advanced technology and cost control, its performance in the market may be more eye-catching.
What are the key steps in the production process of 1H-Pyrazolo [4,3-c] pyridine, 4,5,6, 7-tetrahydro-1-phenyl-
The key steps in the production process of 1H-pyrazolo [4,3-c] pyridine, 4,5,6,7-tetrahydro-1-phenyl-this compound are as follows:
The selection of starting materials is of paramount importance, and suitable pyridine derivatives and phenylhydrazine compounds are often used as starting materials. These two need to be carefully selected to ensure purity and quality before laying a good foundation for subsequent reactions.
Then cyclization is carried out, which is one of the core steps. In a suitable reaction vessel, an appropriate amount of catalyst and solvent is added to control the reaction temperature and time. Temperature control must be accurate, too high or too low will affect the reaction process and product purity. In this process, pyridine derivatives interact with phenylhydrazine compounds to gradually form the basic structure of pyrazolopyridine. This reaction requires close observation and timely adjustment of conditions according to the reaction process to make the reaction proceed smoothly.
The construction of tetrahydropyrazolopyridine structure is also crucial. It is usually achieved by means of hydrogenation reaction. Appropriate hydrogenation reagents and catalysts are selected to react under specific pressure and temperature conditions. This step requires careful operation, because hydrogenation reactions are often more violent, and a little carelessness can cause accidents. Precise control of pressure and temperature, as well as real-time monitoring of the reaction system, can ensure the smooth progress of the reaction and the successful construction of tetrahydropyrazolopyridine structure.
Finally, the separation and purification of the product. After the reaction, the resulting mixture contains the target product and many impurities. Separation methods such as column chromatography and recrystallization are used to precisely separate the target product from the mixture and improve the purity of the product. During column chromatography, appropriate stationary and mobile phases need to be selected, and for recrystallization, appropriate solvents need to be selected, which are all related to the quality of the final product.