1H-pyrazolo[4,3-b]pyridine, 3-methyl-

3-Methyl-1H-pyrazolo [4,3-b] pyridine is an organic compound. Its physical properties are quite critical and are of great significance in both chemical research and practical applications.
First, the appearance is mentioned. Under normal temperature and pressure, 3-methyl-1H-pyrazolo [4,3-b] pyridine is often in solid form, mostly white to light yellow crystalline powder. This appearance feature is convenient for preliminary identification and distinction.
Melting point is one of its important physical parameters. The melting point of this compound is about [X] ° C. The determination of the melting point has a significant effect on the determination of its purity. If the purity is extremely high, the melting point range is usually narrow; conversely, if it contains impurities, the melting point will decrease and the range will become wider.
In terms of boiling point, under specific pressure conditions, the boiling point of 3-methyl-1H-pyrazolo [4,3-b] pyridine is about [X] ° C. The boiling point data is of great significance in the process of separation and purification of this compound. According to its boiling point, a suitable distillation method can be selected for separation operation.
The solubility of this compound cannot be ignored, and the solubility of this compound in organic solvents varies. In common organic solvents such as methanol, ethanol, and dichloromethane, there is a certain solubility, which provides a reference for the selection of solvents in their synthesis, reaction, and separation processes. However, the solubility in water is low, which is due to the large proportion of hydrophobic groups in its molecular structure, which makes the force between it and water molecules weak.
In terms of density, the density of 3-methyl-1H-pyrazolo [4,3-b] pyridine is about [X] g/cm ³, and the density data is indispensable in practical application scenarios such as material balance calculation, storage, and transportation of this compound.
In addition, 3-methyl-1H-pyrazolo [4,3-b] pyridine has certain stability, but its structure may change under extreme conditions such as high temperature, strong acid, and strong base. Understanding these physical properties lays a solid foundation for further research on its chemical properties, related experiments, and practical applications.

3-Methyl-1H-pyrazolo [4,3-b] pyridine, which has many unique chemical properties. In its structure, the thick ring system of pyrazolo-pyridine gives it significant aromaticity. Due to the existence of the conjugate system, the electron cloud can be effectively delocalized and the stability is quite good. In chemical reactions, the conjugate structure affects the electron distribution, making specific positions prone to electrophilic substitution reactions. For example, high electron cloud density check points on the pyrazole ring or pyridine ring, such as the ortho and para-position of the pyridine ring, are more susceptible to electrophilic attack.
Its methyl substituents also affect the chemical properties. The inductive effect and superconjugation effect can be used to increase the electron cloud density of the pyridine ring, which not only enhances the aromaticity, but also changes the reactivity at the reactivity check point on the ring. For example, it will make the adjacent and para-sites of methyl more prone to electrophilic substitution. In the electrophilic substitution reactions such as halogenation, nitrification, and sulfonation, methyl has a significant impact on the reaction check point and reactivity.
In addition, the 3-methyl-1H-pyrazolo [4,3-b] pyridine nitrogen atom has potential alkalinity due to its lone pair electrons, and can react with acids to form salts, or in some reactions as ligands to complex with metal ions to form stable complexes, which has great potential for application in catalysis, materials science and other fields. Due to these unique chemical properties, this compound can be used in the field of medicinal chemistry, or it can be used to develop drugs with specific biological activities based on its structural modification; in materials science, it can be used to prepare functional materials with metal ions.

1H-pyrazolo [4,3-b] pyridine-3-methyl derivatives are widely used. In the field of medicinal chemistry, they can be used as key intermediates to create new drugs. Due to the unique chemical structure of this derivative, it can interact with specific targets in organisms, or it can exhibit significant pharmacological activities, such as anti-tumor, anti-virus, anti-inflammatory and other effects, providing new possibilities for human beings to fight various diseases.
In the field of materials science, it also has extraordinary performance. With its own special structure and properties, through appropriate modification and processing, materials with specific functions can be prepared, such as luminescent materials, conductive materials, etc. These materials can play an important role in many fields such as optoelectronic devices and sensors, and contribute to the continuous progress of related technologies.
In the field of organic synthetic chemistry, 1H-pyrazolo [4,3-b] pyridine-3-methyl derivatives are often used as building blocks for organic synthesis. Chemists can use a variety of chemical reactions to ingeniously modify and expand their structures to construct more complex and novel organic molecules, contributing to the development of organic synthetic chemistry, promoting the field to continue to move forward, and creating more organic compounds with unique properties and application value.

There are several methods for synthesizing 3-methyl-1H-pyrazolo [4,3-b] pyridine. One method can also be started from a suitable pyridine derivative. First, a specific reagent is used to cause a substitution reaction at a specific position on the pyridine ring, and the required substituent is introduced. The key to this depends on the precise regulation of the reaction conditions, such as the choice of temperature, solvent and catalyst, which all need to fit the reaction mechanism. If the temperature is too high or too low, the reaction can go astray, and the polarity and solubility of the solvent are also related to the reaction process.
Second, the cyclization reaction is used to construct the thick ring structure of pyrazolo [4,3-b] pyridine. This step often relies on a suitable condensing agent or catalyst to promote the formation of intracellular rings. During cyclization, the rearrangement of chemical bonds and the formation of new bonds must be carefully controlled to prevent the growth of side reactions and ensure the purity and yield of the target product.
Furthermore, there are also nitrogen-containing heterocyclic compounds as raw materials. The raw material is first modified by functional groups to have a check point for reactivity with pyridine derivatives. Subsequently, in a suitable reaction system, the two undergo a condensation reaction to gradually build the skeleton of the target molecule. In this process, the stability and reactivity of the intermediate are also key considerations. The structure of the intermediate needs to be analyzed and optimized to ensure that it can participate in the subsequent reaction smoothly without being too active and causing the reaction to go out of control.
The process of synthesis is really a deep understanding of the reaction mechanism and subtle control of the conditions, so that the product of 3-methyl-1H-pyrazolo [4,3-b] pyridine can be obtained with high efficiency and purity.

I don't know the price range of 1H + - + pyrazolo [4,3 - b] pyridine, 3 - methyl in the market. The price of these chemical substances often varies for many reasons, such as the source of the material, the difficulty of preparation, the amount of demand, and the quality.
If the material is widely sourced and easy to obtain, and the preparation method is simple and efficient, the cost may be reduced, and the price may be low. On the contrary, if the material is scarce, the preparation requires difficult processes and high-priced reagents, the price will be high.
The impact of demand is also great. If the demand for this product in the chemical, pharmaceutical and other industries is strong and the supply is in short supply, the price will rise; if the demand is weak and the supply exceeds the demand, the price may fall.
The quality is also related to the price. For those with high purity and high quality, the price will be higher than that of ordinary quality.
To know the exact price range, when consulting chemical raw material suppliers, chemical trading platforms, or professionals in related industries, they may be able to give a more accurate price range according to the current market conditions.