1H-Pyrazolo[4,3-b]pyridine, 3-bromo-

3-Bromo-1H-pyrazolo [4,3-b] pyridine, its main application fields involve pharmaceutical chemistry, materials science and organic synthesis.
In the field of medicinal chemistry, this compound is often a key intermediate for the creation of new drugs. Its unique chemical structure gives it the potential to interact with specific targets in organisms, or to develop new drugs for the treatment of anti-tumor, antiviral and nervous system diseases. The structure of Geiinpyrazolo-pyridine is often biologically active, and the introduction of bromine atoms can fine-tune its physicochemical properties and biological activities, such as improving the lipophilicity of the compound and enhancing its transmembrane ability, thereby enhancing the efficacy of drugs.
In the field of materials science, 3-bromo-1H-pyrazolo [4,3-b] pyridine may be used to prepare optoelectronic materials. Because of the conjugated system in its structure, bromine atoms can affect the electron cloud distribution and energy level structure of molecules, or make materials exhibit unique optical and electrical properties. For example, it can be used in the development of organic Light Emitting Diodes (OLEDs), solar cells and other devices, which can optimize the luminous efficiency and stability of the device.
As for the realm of organic synthesis, this compound is an important building block for the construction of complex organic molecules. Bromine atoms are active and can participate in many classical organic reactions, such as Suzuki coupling, Heck reaction, etc. By reacting with various organoboronic acids or olefins, the carbon skeleton of molecules can be expanded, and diverse structural modifications can be achieved. This can assist in the synthesis of complex organic compounds with specific functions and structures, and promote the development of organic synthesis chemistry.

To prepare 3-bromo-1H-pyrazolo [4,3-b] pyridine, the following ancient method can be followed.
First, pyrazolo [4,3-b] pyridine is used as the starting material, so that it reacts with a brominating agent in a temperature-appropriate agent. Select bromine as the brominating agent, in an inert solvent such as dichloromethane, and catalyze it with a suitable catalyst, such as iron powder or iron tribromide. Gradually raise to room temperature at low temperature, and carefully control the temperature during this period to prevent side reactions from occurring. In this reaction, bromine electrophilically attacks the specific position of pyrazolo [4,3-b] pyridine, and is electrophilically substituted to obtain the target product.
Second, the structure of pyrazolo [4,3-b] pyridine is modified first, and a group that can be converted into a bromine atom is introduced. If a diazo group is introduced, it is reacted with pyrazolo [4,3-b] pyridine in an acid solution with an appropriate diazotization reagent to obtain a diazo salt. Then the diazo salt is treated with a reagent such as cuprous bromide. After the Sandmeier reaction, the diazo group is replaced by a bromine atom to obtain 3-bromo-1H-pyrazolo [4,3-b] pyridine.
Third, starting from the construction of the pyrazolo [4,3-b] pyridine ring. With bromine-containing raw materials, cyclization is carried out in multiple steps. For example, with appropriate bromopyridine derivatives and nitrogen-containing bifunctional reagents, under alkali catalysis, through a series of reactions such as condensation and cyclization, one-step cyclization is formed and bromine atoms are introduced into the target position.
During operation, all reactions must abide by chemical test regulations and pay attention to safety. After the reaction, the product is separated and purified, such as column chromatography, recrystallization, etc., to obtain pure 3-bromo-1H-pyrazolo [4,3-b] pyridine.

3-Bromo-1H-pyrazolo [4,3-b] pyridine, this is an organic compound. Its physical and chemical properties are crucial for its application in various fields.
Let's talk about the physical properties first. Generally speaking, this substance is either in a solid state, as for the color, or a white to light yellow powder, which varies depending on the molecular structure and impurity conditions. Its melting point is an important physical constant. It has been experimentally determined that it is about a certain temperature range. This melting point is very helpful for its identification and purification.
Let's talk about chemical properties. Due to the bromine atom and the structure of pyrazolopyridine, this compound has unique chemical activity. Bromine atoms are active and can participate in many nucleophilic substitution reactions, such as reacting with compounds containing hydroxyl groups and amino groups to form new organic compounds. This property is of great significance in the field of organic synthesis, and can be used to construct complex organic molecular structures. Its pyrazolopyridine structure imparts certain alkalinity to the compound and can react with acids to form salts. This property may be used to improve drug solubility and stability in medicinal chemistry.
Furthermore, the stability of this compound is also an important chemical property. Under normal temperature and pressure and dry environment, its properties are relatively stable. In case of strong oxidants, strong acids or strong bases, or under high temperature conditions, the molecular structure may change, triggering chemical reactions.
The physicochemical properties of this 3-bromo-1H-pyrazolo [4,3-b] pyridine lay the foundation for its application in organic synthesis, drug development and other fields. According to its properties, researchers can explore suitable application scenarios and synthesis methods.

I don't know the price range of "1H - Pyrazolo [4,3 - b] pyridine, 3 - bromo -" in the market. This is a more professional chemical substance, and its price will vary due to many factors. First, the purity has a great impact. Those with high purity are expensive, and those with low purity are relatively cheap. Second, the market supply and demand relationship is also key. If there is more demand and less supply, the price will rise; conversely, if the supply exceeds the demand, the price may drop. Third, the manufacturer and the source are different, and the price is also different. Products produced by well-known large factories may be expensive due to factors such as quality control; while some small factory products may be relatively close to the people. In addition, the amount of purchase also affects the price, and bulk purchases can often be discounted.
However, it is difficult for me to determine the specific price range. For details, you can consult chemical product suppliers, chemical trading platforms, or consult relevant industry reports, so as to obtain more accurate price information.

3-Bromo-1H-pyrazolo [4,3-b] pyridine is an important organic compound, which is widely used in medicine, pesticides and other fields. Today, many manufacturers are involved in the production of this compound.
In China, there are many chemical companies in Jiangsu that focus on the production of fine chemicals, some of which involve 3-bromo-1H-pyrazolo [4,3-b] pyridine. With advanced production technology and strict quality control, the products they produce are of high quality and are not only supplied to the domestic market, but also exported overseas.
Shandong also has a chemical industry cluster, some of which have deep attainments in the synthesis of nitrogen-containing heterocyclic compounds. In the production of 3-bromo-1H-pyrazolo [4,3-b] pyridine, they continuously optimize their technology and enhance their product competitiveness.
Internationally, many well-known chemical companies in Europe, America and other regions also produce this compound. Some large chemical companies in the United States, relying on their strong R & D strength and advanced production equipment, produce 3-bromo-1H-pyrazolo [4,3-b] pyridine of excellent quality and are widely used in high-end pharmaceutical research and development.
Under the guidance of the concept of green chemistry and sustainable development, European chemical companies pay attention to environmental protection and efficient use of resources in the production process of 3-bromo-1H-pyrazolo [4,3-b] pyridine, and their products are also favored by the market.
Overall, many manufacturers around the world continue to improve the production technology and product quality of 3-bromo-1H-pyrazolo [4,3-b] pyridine in response to different market needs to meet the needs of development in various fields.