1H-pyrazolo[3,4-c]pyridine, 5-bromo-

1H-pyrazolo [3,4-c] pyridine-5-bromide, this is an organic compound. It has a wide range of uses and is often used as a key intermediate in the field of medicinal chemistry to create new drugs. Due to its specific chemical structure and activity, it can interact with many targets in organisms, such as specific enzymes or receptors. By modifying the structure of the compound, its affinity and selectivity with the target can be adjusted, providing the possibility for the development of drugs with excellent efficacy and less side effects.
In the field of materials science, the compound also shows potential uses. With its unique optoelectronic properties, it is expected to be applied to optoelectronic devices such as organic Light Emitting Diode (OLED) and organic solar cells. For example, by rational molecular design and modification, its luminous efficiency, charge transport performance, etc. can be optimized, thereby improving the performance of optoelectronic devices.
In the field of chemical synthesis, 1H-pyrazolo [3,4-c] pyridine-5-bromide is an important synthetic building block for building more complex and diverse organic molecular structures. Chemists can use the activity check point of this compound according to the principles and methods of organic synthesis to construct organic compounds with unique structures and functions through various chemical reactions, such as nucleophilic substitution, coupling reactions, etc., providing rich materials and diverse paths for the development of organic synthetic chemistry.

1H-pyrazolo [3,4-c] pyridine-5-bromide, this is an organic compound. Its physical properties are quite important and affect many chemical application fields.
This substance is usually in a solid state, and it has a relatively stable form at room temperature and pressure due to the intermolecular forces. Looking at its color, it is mostly white or off-white crystal powder. This pure color state may be due to the regular molecular structure and orderly crystal arrangement.
Melting point is of great significance for its chemical operation and identification. The specific melting point value will vary slightly depending on the purity of the compound and the measured environmental conditions. However, roughly speaking, it falls within a specific temperature range. This temperature range is the critical range for the molecular transition from solid to liquid. This property can help to distinguish the compound and play a key role in the separation and purification process.
Solubility is also an important physical property. In organic solvents, such as common ethanol and dichloromethane, etc., it exhibits a certain solubility. In ethanol, some molecules interact with ethanol molecules by means of intermolecular forces, and then dissolve them. In dichloromethane, its solubility may vary due to the polarity of dichloromethane and the adaptability of the molecular structure to the compound. However, in water, the solubility is poor, which is mainly due to the large proportion of hydrophobic parts in its molecular structure, which is difficult to form effective interactions with water molecules.
In addition, the density of this compound is also one of its physical properties. Density represents the mass of a substance in a unit volume, and this value is of great significance for studying its distribution in different media and the calculation of the dosage when participating in chemical reactions. Compared with other similar structural compounds, its density may vary due to the type, quantity and molecular space arrangement of atoms.
1H-pyrazolo [3,4-c] pyridine-5-bromide has various physical properties, which are interrelated and affect its application in chemical synthesis, drug development and many other fields.

1H-pyrazolo [3,4-c] pyridine-5-bromide, this physical property is relatively stable.
Looking at its structure, the pyrazolo-pyridine ring system has the characteristics of conjugation, which makes the distribution of molecular electron clouds uniform and the structure is solid. Although the bromine atom is highly electronegative, when connected to the ring, through conjugation and induction effect, the charge dispersion is good, and the molecular activity is not abnormal.
In the chemical environment, its stability is multi-terminal. At room temperature, if there is no strengthening effect, such as strong acid, strong base, strong oxidant or reducing agent, this compound can maintain its inherent structure. In case of mild reagents, the reaction selects a specific activity check point, which does not cause the disintegration of the overall structure.
In the field of organic synthesis, it is often used as an intermediate. Its stability guarantees the orderly progress of the synthesis steps and reduces side reactions. Chemists can precisely design the reaction path according to its stability characteristics to achieve the construction of the target product.
However, the stability is not absolute. Its structure may change at high temperature, high pressure or in a specific catalytic environment. Under the catalysis of strong Lewis acid, bromine atoms or involve nucleophilic substitution; at high temperature, the ring system may also open or rearrange.
In conclusion, 1H-pyrazolo [3,4-c] pyridine-5-bromide is usually physically stable, but the chemical world is changeable, and it can also be changed under special conditions. Chemists must take into account the situation and make good use of its properties according to the needs of the reaction.

To prepare 5-bromo-1H-pyrazolo [3,4-c] pyridine, there are many synthesis methods, and the following are listed:
The starting material is selected as a pyridine derivative, and the bromine atom can be introduced at a specific position of the pyridine ring first. In this step, liquid bromine and a suitable catalyst are used to replace the bromine at a selected position under mild heating conditions to obtain a bromine-containing pyridine intermediate. Subsequently, with suitable reagents and conditions, the construction of the pyridine ring is promoted. If a nitrogen-containing heterocyclic reagent is used, under alkali catalysis, through a series of reactions such as nucleophilic substitution and cyclization, the skeleton of the target molecule is gradually formed, and 5-bromo-1H-pyrazolo [3,4-c] pyridine is finally obtained.
If a pyrazole derivative is used as the starting material, the pyrazole ring can be modified first to have the activity check point of fusion with the pyridine ring. If a suitable substituent is introduced at a specific position of the pyrazole, the substitution can be coupled to the pyridine fragment based on the subsequent reaction. Then, with a pyridine-containing structural reagent, under metal catalysis or other promotion conditions, the two are coupled and cyclized. In the process, metal catalysts may affect the selectivity and efficiency of the reaction, and the product needs to be carefully screened. After multi-step reaction, the final product is obtained.
There are also those who construct heterocyclic systems by multi-step reaction. First, from simple organic raw materials, through condensation, cyclization and other reactions, the intermediate containing part of the target structure is constructed. For example, common reagents such as aldodes, ketones, amines, etc. are condensed to form intermediates containing unsaturated bonds, and then through intraconon cyclization and rearrangement, the mother nucleus of pyrazolopyridine is gradually built. After that, bromine atoms are introduced at a suitable stage, and brominated reagents can be used to achieve 5-bromo-1H-pyrazolo [3,4-c] pyridine under controlled reaction conditions, thus completing the synthesis of 5-bromo-1H-pyrazolo [3,4-c] pyridine. In the synthesis, the precise control of each step of the reaction conditions, such as temperature, solvent, reactant ratio, etc., is related to the yield and purity of the product, which needs to be optimized by repeated experiments.

1H-pyrazolo [3,4-c] pyridine, 5-bromo (5-bromo-1H-pyrazolo [3,4-c] pyridine) is useful in various fields.
In the field of pharmaceutical research and development, this compound has great potential. Due to its unique chemical structure, it can be used as a key intermediate for the creation of new drugs. Its structure can interact with specific targets in organisms, or it can be used to develop anti-tumor drugs. The growth and proliferation of tumor cells depend on many specific proteins and signaling pathways. 5-bromo-1H-pyrazolo [3,4-c] pyridine may act precisely on these targets, inhibit the growth of tumor cells, and provide a new way to overcome cancer problems.
In the context of materials science, it also has its place. It can be introduced into polymer materials through specific chemical reactions to give the material special properties. For example, it can improve the optical properties of the material and make it have fluorescent properties, which can be used to prepare fluorescent sensing materials. Such materials can be very useful in environmental monitoring, capable of perceiving specific pollutants in the environment and alerting by changes in fluorescent signals.
In the field of organic synthetic chemistry, 5-bromo-1H-pyrazolo [3,4-c] pyridine is an important cornerstone. Its bromine atom is highly active and can participate in a variety of classical organic reactions, such as Suzuki coupling reaction, Heck reaction, etc. With this, chemists can construct more complex and diverse organic molecules, expand the types and functions of organic compounds, and contribute to the development of organic synthetic chemistry.