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What are the chemical properties of 1H-Pyrazolo [3,4-c] pyridine-3-carboxylic acid, ethyl ester
1H-Pyrazolo [3,4-c] pyridine-3-carboxylic acid ethyl ester, this is an organic compound. Its physical properties are mostly solid at room temperature, or it is a viscous liquid due to slight differences in structure. Looking at its color, it is often white to light yellow powder or crystal. Those who are pure are light in color, and the color may deepen when impurities are included.
Regarding solubility, due to the structure of ester groups and pyridine, it has good solubility in organic solvents such as dichloromethane, chloroform, and tetrahydrofuran, because it can form intermolecular forces with organic solvents. However, the solubility in water is poor, because the overall polarity of the molecule is limited, and the ester group and pyridine ring are not strong hydrophilic groups.
In terms of chemical properties, ester groups are active and can undergo hydrolysis reactions. Under acidic conditions, hydrolysis is slow, and after protonation and other steps, 1H-pyrazolo [3,4-c] pyridine-3-carboxylic acid and ethanol are generated; under basic conditions, hydrolysis is rapid, and hydroxide attacks ester carbonyl carbons. After a series of transformations, the corresponding carboxylic acids and ethanolates are also obtained.
Pyridine rings are basic and can react with acids to form salts. Because nitrogen atoms have lone pairs of electrons, they can accept protons. When exposed to strong acids, pyridine nitrogen atoms protonate to form pyridine salts, which are more soluble in water than parent compounds.
pyrazole ring also has unique reactivity. The hydrogen on the adjacent carbon of the nitrogen atom has a certain acidity. Under the action of strong bases, protons can be deprotonated, and then nucleophilic substitution and other reactions occur, participating in the construction of new carbon-carbon or carbon-hetero bonds. It has a wide range of uses in the field of organic synthesis.
What are the main uses of 1H-Pyrazolo [3,4-c] pyridine-3-carboxylic acid, ethyl ester
1H-pyrazolo [3,4-c] pyridine-3-carboxylate ethyl ester, which has a wide range of uses. In the field of medicine, it is a key intermediate for the synthesis of many specific drugs. Because of its unique chemical structure, it can participate in the construction of molecular structures with specific physiological activities, or help the development of innovative drugs for the treatment of difficult diseases, which is of great significance to human health.
In the field of pesticides, it also shows important value. Using this as a raw material, it can synthesize pesticide products with high insecticidal, bactericidal or herbicidal properties. With its structural characteristics, it can accurately act on specific targets of pests, achieve efficient control, and is relatively friendly to the environment, which is conducive to sustainable agricultural development.
In the field of materials science, 1H-pyrazolo [3,4-c] pyridine-3-carboxylate ethyl ester can be used as an important starting material for the synthesis of functional materials. Through specific chemical reactions, it is integrated into polymer materials or other functional materials to endow materials with unique optical, electrical or mechanical properties, meeting the needs of special materials in cutting-edge fields such as electronics and optics.
It can be seen that 1H-pyrazolo [3,4-c] pyridine-3-carboxylate ethyl ester plays a key role in many fields such as medicine, pesticides and materials science, promoting technological innovation and progress in various fields.
What is the synthesis method of 1H-Pyrazolo [3,4-c] pyridine-3-carboxylic acid, ethyl ester
The synthesis of 1H-pyrazolo [3,4-c] pyridine-3-carboxylate ethyl ester is an important technique in the field of chemistry. To synthesize this compound, the following steps can be followed.
The first step is to select suitable starting materials. Usually, the compound containing the pyridine structure and the reagent containing the pyrazole structure are used as the starting materials. If the specific substituted pyridine derivative and the pyrazole derivative are used as the basis, the two need to have a reactive activity check point for subsequent reactions to proceed.
The second step is to use suitable reaction conditions. Reaction types common in organic synthesis, such as nucleophilic substitution reactions, cyclization reactions, etc. In the nucleophilic substitution reaction, appropriate bases and solvents need to be selected. The base can promote the deprotonation of the reaction substrate and enhance its nucleophilicity; the solvent needs to have good solubility to the reactants and products without interfering with the reaction process. If potassium carbonate is used as a base and N, N-dimethylformamide (DMF) is used as a solvent, the reaction can proceed smoothly. The
cyclization reaction step is also crucial. Under the action of suitable temperature and catalyst, the intramolecular ring is promoted to form the core structure of pyrazolo [3,4-c] pyridine. This process requires strict control of the reaction temperature. Too high or too low temperature may affect the selectivity and yield of the reaction. If the reaction temperature is maintained between 80 and 100 degrees Celsius, a specific metal catalyst can be used to effectively catalyze the cyclization reaction.
Furthermore, the reaction products are separated and purified. After the reaction, the mixture contains the target product, unreacted raw materials and by-products. Column chromatography, recrystallization and other means can be used for separation. Column chromatography achieves separation according to the difference in material polarity, and recrystallization method uses the different solubility of the product and impurities in different solvents for purification.
Through the above series of steps, the reaction conditions and fine separation and purification can be reasonably controlled to obtain 1H-pyrazolo [3,4-c] pyridine-3-carboxylate ethyl ester. This synthesis method requires the experimenter to have solid knowledge of organic chemistry and skilled experimental operation skills in order to ensure the smooth progress of the reaction and obtain high-purity products.
What is the price range of 1H-Pyrazolo [3,4-c] pyridine-3-carboxylic acid, ethyl ester in the market?
At present, I want to know the price range of 1H - Pyrazolo [3,4 - c] pyridine - 3 - carboxylic acid, ethyl ester in the market, but the market situation is complex and changeable, and this price is difficult to determine. Looking at the market conditions of various materials in the past, the fluctuation of prices often depends on multiple factors.
First, the origin of the material, that is, the raw material required for its preparation, if the raw material is easy and abundant, the price is flat; if the raw material is rare and difficult to find, the price will be high. The raw material of this compound, if it has a special source, or requires exquisite processes to be prepared, its price will be high.
Second, the simplicity of the process is also heavy. To prepare this compound, if the process is complicated, exquisite skills and high-end equipment are required, manpower and material resources are wasted, and the price also increases. If the process is simple and efficient, the cost will be reduced and the price will be lower.
Third, the supply and demand of the city will also affect its price. If many industry players compete for this product, the demand will exceed the supply, and the price will rise; if the market is lack of interest, the supply will exceed the demand, and the price will fall.
Fourth, the situation of the world and changes in government orders also have an impact. The regulations of the place of origin and trade can make the price fluctuate.
Although it is difficult to determine the price, the price of such fine chemicals in the past may range from tens to hundreds of yuan per gram if the quality is ordinary and the quantity is large and the demand is small; if the quality is excellent, it is for specific high-end use, or the quantity is small and the demand is large, the price can reach more than 1,000 yuan per gram, even more expensive. This is only a guess, and the actual price needs to be carefully examined at that time.
What are the storage conditions for 1H-Pyrazolo [3,4-c] pyridine-3-carboxylic acid, ethyl ester?
1H-Pyrazolo [3,4-c] pyridine-3-carboxylate ethyl ester, this is an organic compound. Its storage conditions are quite critical, related to the stability and quality of the substance.
According to the method of ancient people's storage, the properties of this compound should be viewed in a cool place. Due to the heat, it is easy to change it and damage its inherent quality. A cool place can slow down the rate of chemical change, so that the structure is stable and will not decompose or deteriorate.
Furthermore, it needs to be placed in a dry place. Water vapor is the enemy of many substances, and moisture can easily cause reactions such as hydrolysis, causing it to lose its original properties. If the object is stored in the box, a dry place must be selected to ensure that it is not damaged for a long time.
In addition, this compound should be kept away from fire sources and oxidants. Because of its flammability, it may be dangerous in case of open flames and hot topics; and the contact of oxidants with it can easily induce violent chemical reactions and endanger safety.
When storing, it needs to be sealed and stored. The composition of the outside air is complex, and many gases may interact with it. Sealing can block external interference and maintain its pure state.
In conclusion, store 1H-pyrazolo [3,4-c] pyridine-3-carboxylate ethyl ester in a cool, dry place, away from sources of ignition and oxidants, and properly sealed, so that it can maintain its inherent properties for a long time for future use.