1H-Pyrazolo[3,4-b]pyridine, 5-bromo-

5-Bromo-1H-pyrazolo [3,4-b] pyridine has a wide range of uses. In the field of medicinal chemistry, it is often a key intermediate for the synthesis of many effective drugs. Due to the unique structure of pyrazolopyridine, the prepared drugs are endowed with outstanding biological activity and pharmacological properties. For example, when developing new anti-tumor drugs, compounds that can precisely act on specific targets of tumor cells can be obtained by ingeniously modifying and modifying the structure of the substance, effectively inhibiting the proliferation and spread of tumor cells, adding to the problem of cancer.
In the field of pesticide research and development, 5-bromo-1H-pyrazolo [3,4-b] pyridine also has important value. With this as the starting material, high-efficiency, low-toxicity and environmentally friendly pesticides can be synthesized through a series of reactions. Such pesticides can precisely act on the specific physiological processes of pests, interfering with their normal growth and reproduction, so as to achieve good pest control effects, while minimizing the harm to the environment and non-target organisms, which is in line with the current needs of green agriculture development.
In the field of materials science, this compound has also emerged. Through appropriate chemical reactions, it can be introduced into polymer materials or functional materials, giving the materials special optical, electrical or mechanical properties. For example, materials with unique luminescence properties are prepared and applied to optoelectronic devices such as organic Light Emitting Diodes (OLEDs) to improve the luminous efficiency and stability of the devices, injecting new vitality into the innovation and development of materials science.
In addition, in the field of organic synthetic chemistry, 5-bromo-1H-pyrazolo [3,4-b] pyridine is a key intermediate, participating in the construction of a variety of complex organic compounds. Its bromine atom has high activity and can be linked to other organic fragments through nucleophilic substitution, coupling and other reactions, providing an effective way for the synthesis of organic molecules with diverse structures and unique functions, which greatly promotes the progress and development of organic synthetic chemistry.

5-Bromo-1H-pyrazolo [3,4-b] pyridine is an organic compound. Its physical properties are quite important and play a key role in chemical research and various applications.
Looking at its properties, under normal temperature and pressure, 5-bromo-1H-pyrazolo [3,4-b] pyridine is often in a solid state. Its color may be white to off-white powder, which is easy for researchers to intuitively identify.
When it comes to melting point, this compound has a specific melting point value. The melting point is the temperature at which a substance changes from a solid state to a liquid state. The melting point of 5-bromo-1H-pyrazolo [3,4-b] pyridine is within a certain range, and this value may vary slightly due to factors such as the purity of the compound. Accurate determination of the melting point can help determine its purity and identify the characteristics of the compound.
Furthermore, solubility is also one of its important physical properties. Among common organic solvents, 5-bromo-1H-pyrazolo [3,4-b] pyridine exhibits different solubility. In some organic solvents such as dichloromethane, N, N-dimethylformamide, etc., it may have a certain solubility. In water, its solubility is relatively low. This difference in solubility needs to be taken into account in the synthesis, separation, purification and application of compounds.
In addition, its density also has a corresponding value. The density reflects the mass per unit volume of the substance, and the density of 5-bromo-1H-pyrazolo [3,4-b] pyridine has a certain impact on its distribution, mixing and related process design in the reaction system.
As for the boiling point, under specific pressure conditions, when 5-bromo-1H-pyrazolo [3,4-b] pyridine reaches a certain temperature, the liquid will vaporize violently, which is the boiling point. Although the boiling point is rarely directly considered in practice, it is also a parameter that cannot be ignored when fully understanding the physical properties of the compound.
In conclusion, the physical properties of 5-bromo-1H-pyrazolo [3,4-b] pyridine, such as appearance, melting point, solubility, density, boiling point, etc., are all related and affect their application and research in the field of chemistry. Researchers must investigate in detail to make good use of the properties of this compound for various chemical purposes.

The method for synthesizing 5-bromo-1H-pyrazolo [3,4-b] pyridine is described below.
First, a suitable starting material is taken, often starting with a pyridine derivative. The pyridine derivative is subjected to a specific substitution reaction, which aims to introduce a group that can subsequently construct a pyrazole ring. Generally, a nitrogen-containing heterocyclic compound can be selected, and a nitrogen-containing group is attached to a specific position on the pyridine ring by a reaction such as nucleophilic substitution. This reaction needs to be carried out under appropriate reaction conditions, such as suitable solvents, temperatures and catalysts.
After that, a cyclization reaction is carried out to construct a pyrazole ring. In this process, the reaction conditions need to be carefully controlled to promote the formation of intra-molecular rings. Factors such as reactant concentration, reaction temperature and reaction time are usually considered. Too high or too low temperature may affect the efficiency and selectivity of the cyclization reaction. Generally speaking, a suitable base is selected as a catalyst to promote the cyclization reaction to occur smoothly.
Next, for the constructed 1H-pyrazolo [3,4-b] pyridine structure, a bromination reaction is carried out to introduce bromine atoms. A variety of bromination reagents can be used for the bromination reaction, such as liquid bromine, N-bromosuccinimide (NBS), etc. If NBS is used as a brominating reagent, it is often necessary to react in an organic solvent under the condition of light or the presence of an initiator. Pay attention to the amount of brominating reagent during the reaction to avoid excessive bromination, so as to accurately obtain 5-bromo-1H-pyrazolo [3,4-b] pyridine.
After each step of the reaction is completed, suitable separation and purification methods, such as column chromatography, recrystallization, etc. need to be used to remove reaction by-products and unreacted raw materials to improve the purity of the product. In this way, through multi-step reaction and purification operations, the target product 5-bromo-1H-pyrazolo [3,4-b] pyridine can be obtained.

I don't know the price of "1H - Pyrazolo [3,4 - b] pyridine, 5 - bromo -" in the market. This is a fine chemical, and its price often varies depending on factors such as purity, yield, supply and demand, and market conditions.
If the purity is high and it is experimental grade, it can be expensive for scientific research. Because the preparation requires complex processes, purification is also difficult, and it is oriented to scientific research needs, the quantity is small and the cost is high. Or it can reach hundreds or even thousands of yuan per gram.
If it is industrial grade, it is used for large-scale production. Due to the large output, the cost or dilution. However, it also depends on the cost of raw materials and the difficulty of production. If the raw materials are easily available, the process is mature, and the price is relatively close to the people, per kilogram or thousands of yuan; if the raw materials are scarce, the process is cumbersome, and the price is still high, per kilogram or more than 10,000 yuan.
Furthermore, supply and demand have a great impact on market conditions. Demand is strong and supply is tight, and prices must rise; conversely, supply exceeds demand, and prices may be depressed. And different seasons and regions have different prices. In order to know the exact price, you need to consult chemical raw material suppliers and reagent companies in detail, and get the actual price according to the current specific situation.

5-Bromo-1H-pyrazolo [3,4-b] pyridine is an extremely important chemical substance, and its storage conditions are of great importance, so it needs to be handled with caution in ancient methods.
This substance should be stored in a cool and dry place. Because of the cool place, it can reduce the risk of chemical reactions caused by excessive temperature. If placed in a high temperature place, the molecular activity will increase greatly, or it will cause many adverse changes such as decomposition and deterioration, which will damage the stability of its chemical properties. The dry environment is also indispensable. Moisture can easily lead to reactions such as hydrolysis, which will reduce the purity and quality of the substance.
Furthermore, it should be avoided from contacting with oxidants. The oxidizing agent has strong oxidizing properties, and 5-bromo-1H-pyrazolo [3,4-b] pyridine meets it, or causes a violent oxidation reaction, causing combustion, explosion and other dangers, endangering safety.
At the same time, the storage place must be well ventilated. If the ventilation is poor, once the substance evaporates slightly, it accumulates in a limited space, and the concentration gradually increases, which not only increases the safety hazard, but also may affect the stability of the substance itself.
And it needs to be placed out of the reach of children to prevent accidental ingestion and cause physical damage. For its storage environment, it should be checked regularly to see if its packaging is in good condition, whether the environmental temperature and humidity are appropriate, so that 5-bromo-1H-pyrazolo [3,4-b] pyridine can be safely stored during storage, and its chemical properties are as stable as ever.