1H-Imidazo[4,5-b]pyridine,4-oxide (8CI,9CI)

This is a 1H-imidazolo [4,5-b] pyridine-4-oxide (8CI, 9CI), whose chemical structure is formed by fusing an imidazole ring with a pyridine ring. The imidazole ring is a five-membered heterocyclic ring containing two nitrogen atoms, and the pyridine ring is a six-membered heterocyclic ring containing one nitrogen atom. The two are fused in a specific way and are connected to the pyridine ring at the [4,5-b] position of the imidazole ring. The 4-oxide indicates that the nitrogen atom at position 4 of the pyridine ring is oxidized to the nitrogen oxide form. This structure endows the compound with unique chemical and physical properties, which are of great significance in the fields of organic synthesis, medicinal chemistry, etc. Because the unique structure can participate in a variety of chemical reactions or exhibit specific biological activities, it lays the foundation for the development of new drugs and new materials.

1H-imidazolo [4,5-b] pyridine-4-oxide (8CI, 9CI), this is an organic compound with several unique physical properties.
Its appearance is often white to light yellow crystalline powder, which is easy to identify intuitively. In terms of solubility, it is slightly soluble in water, but soluble in some organic solvents, such as ethanol, dichloromethane, etc. Such solubility characteristics are of great significance in the process of organic synthesis and separation, and a suitable solvent system can be selected accordingly to achieve effective reaction and separation.
The melting point is a specific temperature range, between about 180-185 ° C. As an inherent property of a substance, the melting point can be used to determine the purity. If the purity of the substance is high, the melting point range is narrow and approaches the theoretical value; if it contains impurities, the melting point is reduced and the range becomes wider.
The stability of this compound is considerable, and it can exist stably under normal environmental conditions. However, when exposed to strong oxidizing agents, strong acids or strong bases, chemical reactions are prone to occur, causing structural changes. This balance of chemical stability and reactivity needs to be carefully considered during storage and use to ensure that its performance is not affected.
Its density is also an important physical parameter, about 1.4 - 1.5 g/cm ³. Density plays a key role in the packaging, transportation, and some application scenarios involving the relationship between mass and volume of substances.
The above physical properties are all indispensable factors to consider in the research, production and application of 1H-imidazolo [4,5-b] pyridine-4-oxide, helping researchers and producers to better control this substance.

1H-imidazolo [4,5-b] pyridine-4-oxide (8CI, 9CI) has a wide range of uses. In the field of medicinal chemistry, this compound is often the key raw material for the creation of new drugs. Due to its unique chemical structure, it can interact with specific targets in organisms, or can regulate physiological processes in organisms, such as participating in the regulation of signal transduction pathways, and is expected to be developed into therapeutic drugs for specific diseases, such as anti-tumor and antiviral drugs.
In the field of materials science, it may be used as an important building block for the construction of functional materials. With its structural properties, it may endow materials with special optical and electrical properties. For example, in the field of organic optoelectronic materials, it can be used to participate in the construction of new luminescent materials or conductive materials, which is expected to improve the properties of materials and contribute to the development of display technology, energy storage and other fields.
Furthermore, in organic synthetic chemistry, 1H-imidazolo [4,5-b] pyridine-4-oxide is often used as a key intermediate. Chemists can introduce different functional groups by performing a series of chemical reactions on it, such as substitution reactions, addition reactions, etc., and then synthesize organic compounds with more complex and diverse structures, enrich the variety of organic compounds, and open up new paths for the development of organic synthetic chemistry.

The synthesis of 1H-imidazolo [4,5-b] pyridine-4-oxide (8CI, 9CI) has attracted much attention in the field of chemical synthesis. The synthesis of this compound often requires the delicate design of the reaction path and the comprehensive application of various organic reaction principles.
One method can start from a suitable pyridine derivative. First, the electrophilic substitution reaction occurs at a specific position of the pyridine ring, and a suitable substituent is introduced to lay the foundation for the construction of the imidazole ring. For example, the pyridine containing a specific substituent is used as a raw material, and the appropriate halogen is heated in an organic solvent in the presence of a base to form a pyridine intermediate with a specific substitution mode.
Then, the imidazole ring is formed by cyclization reaction. In this step, the pyridine intermediate and the nitrogen-containing bifunctional group reagent can be used. Under appropriate reaction conditions, such as high temperature and specific catalysts, an intracellular nucleophilic substitution reaction occurs, which promotes the closure of the imidazole ring, and then generates a 1H-imidazolo [4,5-b] pyridine skeleton.
Finally, the obtained product is oxidized to obtain the target 4-oxide. Commonly used oxidants, such as hydrogen peroxide, m-chloroperoxybenzoic acid, etc., can oxidize nitrogen atoms on the pyridine ring into oxide forms under suitable solvents and reaction temperatures to achieve the synthesis of 1H-imidazolo [4,5-b] pyridine-4-oxide.
There is another way, which can be started from imidazole derivatives. First, the imidazole ring is modified, and a bridging group connected to the pyridine ring is introduced, and then the pyridine ring part is constructed through subsequent reactions. For example, a specific substituted imidazole is used as the starting material and reacted with a suitable bifunctional reagent to form a bridging intermediate. After that, the pyridine ring is gradually constructed through multi-step reactions, such as nucleophilic addition, elimination, etc., and finally the target product is obtained through oxidation steps.
During the synthesis process, the reaction conditions, such as temperature, reaction time, ratio of reactants, and solvent selection, need to be carefully adjusted to ensure the high efficiency of the reaction and the purity of the product. The ideal synthesis of 1H-imidazolo [4,5-b] pyridine-4-oxide can be achieved.

The specifications of 1H-imidazolo [4,5-b] pyridine-4-oxide (8CI, 9CI) commonly found in the market are many different. The common specifications of this compound are related to purity, and there are many high purity ones, up to 95%, 98% or even 99%. High purity is suitable for high-end scientific research, pharmaceutical research and development and other fields that require strict impurity content. Because of its small number of impurities, it does not disturb the reaction process and the accuracy of results. The second is the packaging specifications. Small packages are common such as 1 gram, 5 grams, and 10 grams, which are convenient for laboratory trial and exploration of reaction conditions. Large packages have 100 grams, 500 grams, or even 1 kilogram and 5 kilograms, which are required for industrial production and large-scale experiments. Furthermore, the particle size specifications are also different. Fine powders are conducive to dissolution and reaction, and the contact area is large, and the reaction rate can be increased; coarse grains or in specific scenarios, such as some processes that require fluidity, have unique advantages. In addition, solvent residue specifications also need to be paid attention to. Those with low residue are better to avoid adverse effects on subsequent reactions or product quality. In short, the specifications of this compound on the market are diverse and suitable for their own uses. Buyers should choose carefully according to their own needs.