1-methyl-1,2-dihydropyridine-3-carboxylic acid

1 - methyl - 1,2 - dihydropyridine - 3 - carboxylic acid is an organic compound with unique chemical properties. In this compound, the presence of a pyridine ring endows it with certain aromatic and conjugated system properties.
As far as its acidity and alkalinity are concerned, due to the carboxylic group (-COOH), it can exhibit acidity under suitable conditions, and can neutralize with the base to release protons (H 🥰) to form corresponding carboxylic salts. The acidity of the carboxylic group is due to the synergy effect between the carbonyl group (C = O) and the hydroxyl group (-OH), which makes the hydrogen in the hydroxyl group easier to dissociate. The 1-methyl substituent in the
molecule has an effect on the electron cloud distribution and spatial structure of the molecule. The methyl group is the power supply group, which will increase the electron cloud density on the pyridine ring, which will affect its reactivity to a certain extent. In the electrophilic substitution reaction, the substituent may be guided to a specific position on the pyridine ring.
The 1,2-dihydropyridine part has a certain degree of unsaturation due to the existence of double bonds. This unsaturated structure can participate in addition reactions, such as addition with electrophilic reagents or nucleophiles, resulting in changes in the molecular structure. Its reactivity is restricted by the electronic and spatial effects of the pyridine ring and other substituents. In addition, the compound can participate in a variety of organic synthesis reactions due to the presence of multiple reactive functional groups, such as esterification reactions, where carboxyl groups and alcohols can form corresponding esters under acid catalysis; or by reacting with other compounds containing active groups, more complex organic molecular structures can be constructed, which has important application value in the field of organic synthetic chemistry.

1-Methyl-1,2-dihydropyridine-3-carboxylic acid, Chinese name 1-methyl-1,2-dihydropyridine-3-carboxylic acid, this compound has a wide range of uses.
In the field of medicine, it is an important intermediate in organic synthesis. It can participate in the construction of a variety of drug molecules and help develop new drugs. Gein 1,2-dihydropyridine has a unique structure and potential biological activity. With this compound, it can synthesize drugs for the cardiovascular system, regulate blood pressure and heart rate, and improve heart function. Some studies have shown that drugs containing 1,2-dihydropyridine structure have curative effects on hypertension and arrhythmia. < Br >
In the field of materials science, it can be used to prepare materials with special properties. Because its molecular structure contains pyridine rings and carboxyl groups, it can chemically react with other substances to prepare functional polymer materials. If polymerized with specific monomers, materials responsive to environmental factors (such as temperature, pH value) can be prepared for use in smart drug release systems or environmental sensors.
In the field of organic synthesis chemistry, it is a key building block for the construction of complex organic molecules. Through various chemical reactions, such as esterification and amidation, different functional groups can be introduced, and the diversity of molecular structures can be expanded. It provides the possibility for organic synthesis chemists to create novel structural compounds, which is of great significance for the research and development of new drugs and the total synthesis of natural products. < Br >
This compound plays an important role in the fields of medicine, materials, and organic synthesis, promoting the development of various fields.

The synthesis methods of 1-methyl-1,2-dihydropyridine-3-carboxylic acid (1-methyl-1,2-dihydropyridine-3-carboxylic acid) have been around for a long time and are diverse. The following are some common methods introduced by you:
First, a compound containing a pyridine ring is used as the starting material. Appropriate pyridine derivatives can be found and modified by specific reaction conditions. If a pyridine with a suitable substituent is selected, a methyl group is first introduced at a specific position. A nucleophilic substitution reaction can be used to make a suitable methylation reagent, such as iodomethane, react with a pyridine derivative under basic conditions, and then connect a methyl group at a specific position. Then, the pyridine ring is reduced to form a 1,2-dihydropyridine structure. Catalytic hydrogenation can be used, and a suitable catalyst, such as palladium carbon, can be selected to partially reduce the pyridine ring to 1,2-dihydropyridine at a suitable pressure and temperature. Finally, through a suitable reaction, a carboxyl group is introduced at the 3 position. For example, a halogenated pyridine derivative is reacted with metal magnesium to make a Grignard reagent, which is then reacted with carbon dioxide to introduce a carboxyl group.
Second, a multi-step reaction is used to construct a pyridine ring. First, the pyridine ring skeleton is constructed by condensation and cyclization with appropriate organic small molecules as raw materials. For example, ethyl acetoacetate, formaldehyde and ammonia are used as starting materials, and under appropriate catalyst and reaction conditions, the pyridine ring is formed by condensation reaction. During the reaction process, the reaction sequence can be cleverly designed so that methyl and carboxyl groups are introduced at suitable steps. Methylation reagents can be introduced to form methyl substituted structures first, and then carboxyl groups are introduced at the 3 position of the pyridine ring by suitable oxidation or carboxylation reactions.
Third, the reaction is catalyzed by transition metals. Transition metals play an extraordinary role in organic synthesis. Suitable transition metal catalysts such as copper and palladium can be selected. Using compounds containing alkenyl groups and nitrile groups as raw materials, cyclization reactions occur under the catalysis of transition metals to construct a pyridine ring structure. During the reaction process, methyl and carboxyl groups can be introduced at the desired position by regulating the structure and reaction conditions of the reaction substrate. For example, the alkenyl nitrile compound and the methylating reagent are first coupled under the catalysis of transition metals, and methyl groups are introduced, and then hydrolyzed to form carboxyl groups.
All these methods have their own advantages and disadvantages. The synthesis needs to be carefully selected according to actual needs and conditions.

I have not obtained the exact price of 1-methyl-1,2-dihydropyridine-3-carboxylic acid in the market. However, this price often varies due to various reasons, such as the quality of the product, the state of supply and demand, the method of preparation and the place of sale.
If the quality is good, the price may be high; if the quality is poor, the price may be low. If the demand for this product exceeds the supply, the price will rise; if the supply exceeds the demand, the price will fall. Different production methods have different costs and prices. And if it is sold in various places, the price will also vary due to the difference in taxes and freight. < Br >
If you want to know the exact price, you should consult chemical manufacturers, chemical markets, or search on the chemical trading network. You can get the quotations of various companies and compare them with each other to know the approximate price range.

1 - methyl - 1,2 - dihydropyridine - 3 - carboxylic acid, that is, 1 - methyl - 1,2 - dihydropyridine - 3 - carboxylic acid, this is an organic compound, which is widely used in the fields of medicine, pesticides and materials science. However, the exact manufacturer is not known in the books.
Although the name of the specific manufacturer is not obtained, the relevant production clues can be inferred according to its chemical properties and application direction. This compound contains pyridine rings and carboxyl groups, and is synthesized or involved in the construction of pyridine compounds and the introduction of carboxylic groups. In the field of organic synthesis chemistry, manufacturers who master the synthesis process of pyridine compounds may have the possibility of producing this substance.
In the field of medicine, because of its biological activity, some pharmaceutical companies that focus on the development and production of cardiovascular and nervous system drugs may have demand and capacity for them. In the field of pesticides, some companies that create new pesticides may be involved in the production of pesticide active ingredients containing pyridine structures if their research and development involves the production of pesticide active ingredients.
In the field of materials science, if this material is used to prepare special functional materials, such as conductive polymers, liquid crystal materials, etc., companies engaged in the development and production of functional materials may also be potential producers.
To know the exact manufacturer, you can check the chemical product catalog, chemical trading platform, or consult industry experts, chemical industry associations, etc. for more accurate and detailed information.