1-H-2-Trifluoromethylimidazo(4,5-b)-6-chloropyridine

1-H-2-trifluoromethyl imidazolo (4,5-b) -6-chloropyridine is one of the organic compounds with unique chemical properties.
In terms of physical properties, it is a solid at room temperature. Due to the chlorine atom and trifluoromethyl in the molecular structure, the intermolecular force is complicated. Chlorine atoms have certain electronegativity and can participate in the formation of dipole-dipole interactions; fluorine atoms in trifluoromethyl are extremely electronegative, which makes the group have strong electron absorption, or affects the melting point and boiling point of compounds. Generally speaking, such structures or melting points are higher, and more energy is required to remove the molecules from the lattice due to the enhanced intermolecular force.
Chemically, the imidazolopyridine structure of the compound makes it alkaline. Because the nitrogen atom contains lone pairs of electrons, it can accept protons. And the strong electron-absorbing effect of trifluoromethyl may enhance this basicity. At the same time, the activity of the 6-position chlorine atom is quite high, and nucleophilic substitution reactions can occur. Nucleophiles such as alkoxides and amines can attack the carbon attached to the chlorine atom, and the chlorine atom leaves in the form of chloride ions to form new derivatives. This property can be used to construct more complex molecular structures in organic synthesis.
In addition, due to the presence of trifluoromethyl, the compound has good stability and hydrophobicity. The C-F bond energy in trifluoromethyl is high and it is not easy to break, so the compound is more stable in chemical reactions and environments. Hydrophobicity makes the compound unique in the distribution behavior of aqueous and organic phases, and may have special applications in the field of drug development and materials science.
The physical and chemical properties of 1-H-2-trifluoromethyl imidazolo (4,5-b) -6-chloropyridine give it broad application prospects in organic synthesis, pharmaceutical chemistry and other fields. It can be used as a key intermediate for the synthesis of compounds with specific biological activities or material properties.

1-H-2-trifluoromethyl imidazolo (4,5-b) -6-chloropyridine has a wide range of uses. In the field of medicinal chemistry, it is often used as a key intermediate to help create new drugs. Due to its unique chemical structure and properties, it can participate in a variety of chemical reactions, build complex active molecular structures, and then develop specific drugs for specific diseases. For example, in the development of anti-tumor drugs, its structure can be modified to improve the targeting and inhibitory effect on tumor cells.
In the field of pesticide chemistry, it also plays an important role. It can be used as a basic raw material to synthesize pesticide products with high insecticidal, bactericidal or weeding properties. Due to its special structure, pesticides are endowed with a unique mechanism of action, or can improve the control effect against pests and pathogens, and are relatively friendly to the environment, which is in line with the current needs of green pesticide development.
In addition, in the field of materials science, this compound may be used to prepare materials with special properties due to its own characteristics. For example, by participating in the synthesis of functional polymer materials, materials such as corrosion resistance, friction resistance or special optical and electrical properties are endowed, opening up new directions for the development of materials science. Its application in many fields shows great potential and value, promoting technological progress and innovation in various related fields.

The synthesis method of 1-H-2-trifluoromethyl imidazolo (4,5-b) -6-chloropyridine is a key research point in the field of organic synthetic chemistry. To synthesize this compound, various paths can be followed, and the following are commonly used methods.
The selection of starting materials is quite important. Usually 6-chloropyridine-2-amine and ethyl trifluoroacetoacetate are used as starting materials. In the first step of the reaction, 6-chloropyridine-2-amine and ethyl trifluoroacetoacetate are placed in an appropriate organic solvent, such as ethanol or dichloromethane, and an appropriate amount of catalyst, such as p-toluenesulfonic acid, is added. The purpose of this step is to make the condensation reaction between the two occur to form a key intermediate. During the reaction process, the reaction process needs to be closely monitored, which can be tracked by means of thin-layer chromatography (TLC). When the raw material point is basically eliminated, it indicates that the reaction is approaching completion.
After the intermediate is formed, the next cyclization reaction is carried out. The intermediate is transferred to another reaction system, and a suitable dehydrating agent, such as phosphorus pentoxide or phosphorus oxychloride, is added to promote the cyclization reaction under heating. This process requires strict control of the reaction temperature and time. If the temperature is too high or the time is too long, it may lead to the generation of side reactions and affect the purity and yield of the target product. After the reaction is completed, the product is separated by conventional separation and purification methods, such as column chromatography, using silica gel as the stationary phase and the mixed solvent of petroleum ether and ethyl acetate as the mobile phase. Pure 1-H-2-trifluoromethyl imidazolo (4,5-b) -6-chloropyridine is obtained.
In addition, there are other synthesis strategies. For example, 2-chloro-6-aminopyridine is used as the starting material, first reacted with trifluoromethylation reagents, trifluoromethyl is introduced, and then the imidazolopyridine structure is constructed by cyclization reaction. Although the steps of this path are slightly different, precise control of reaction conditions and efficient separation and purification methods are the keys to achieving high-purity target products. During the synthesis process, the optimization of reaction conditions, the inhibition of side reactions, and the purification of the product are all core elements for obtaining high-quality 1-H-2-trifluoromethylimidazolo (4,5-b) -6-chloropyridine.

I don't know what the market price of "1 - H - 2 - Trifluoromethylimidazo (4,5 - b) -6 - chloropyridine" is. This is a specific compound in the field of fine chemicals, and its price is determined by many factors.
First, the difficulty of the preparation process is extremely critical. If the synthesis requires complicated steps, special reagents or harsh reaction conditions, the cost will be high, and the price will also rise. For example, some compounds that require multiple organic synthesis steps and have limited yield per step cost a lot to obtain the target product, and their market price is not cheap.
Second, the amount of market demand also has an impact. If the compound is in high demand in the fields of pharmaceuticals, materials science, etc., and the supply exceeds the demand, the merchant may raise the price; conversely, if the demand is low, the price may be reduced for promotion.
Third, the purity requirements are related to the price. High-purity products are difficult to prepare, the cost increases, and the price is also high. For example, high-purity compounds used in high-end scientific research or pharmaceutical production, the price is much higher than that of ordinary purity.
Fourth, the production scale cannot be ignored. Large-scale production can reduce the unit cost by means of scale effect, and the price may have room to decline; small-scale production is relatively expensive, and the price is difficult to drop.
We have not found the exact price information for this compound. If you want to know more, you can consult chemical product suppliers, chemical product trading platforms, or industry experts to obtain a more accurate price.

1-H-2-trifluoromethyl imidazolo (4,5-b) -6-chloropyridine, this is a chemical substance. During storage and transportation, many matters need to be paid attention to.
Bear the brunt, the storage environment is crucial. Find a cool, dry and well-ventilated place. If the environment is humid, the chemical substance may deteriorate due to moisture absorption, affecting its chemical properties and purity. Temperature also needs to be strictly controlled. Excessive temperature may cause chemical reactions or even safety accidents; too low temperature may cause crystallization or solidification, which also affects its quality.
Furthermore, ensure that the packaging is intact during transportation. The packaging of this chemical substance needs to be sturdy and can withstand a certain external force impact to prevent the packaging from being damaged during transportation, resulting in material leakage. Once a leak occurs, it will not only cause material waste, but also pose a threat to the environment and personnel safety.
At the same time, whether it is storage or transportation, it should be strictly separated from oxidants, acids, alkalis and other substances. Because of its active chemical properties, contact with these substances is very likely to cause severe chemical reactions, such as combustion, explosion and other serious consequences.
In addition, storage and transportation sites must be equipped with professional emergency treatment equipment and equipment. In the event of an unexpected situation such as leakage or fire, effective emergency treatment can be carried out quickly to reduce losses and hazards. Operators also need to undergo professional training to be familiar with the characteristics of the substance and emergency treatment methods to ensure standard operation and safety. In this way, the safety of personnel, environmental safety and the quality of the substance will not be damaged during the storage and transportation of 1-H-2-trifluoromethylimidazolo (4,5-b) -6-chloropyridine.