1-Benzyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine

1-Benzyl-4- (4,4,5,5-tetramethyl-1,3,2-dioxoboran-2-yl) -1,2,3,6-tetrahydropyridine This substance is widely used in the field of organic synthesis.
First, it is often used as a key intermediate to construct complex organic molecular structures. In medicinal chemistry, it can participate in the synthesis of many active pharmaceutical ingredients through its unique structure. For example, many heterocyclic compounds with specific physiological activities need to use this substance to build a core skeleton through clever reaction steps, and then introduce various functional groups to shape the molecular morphology that meets pharmacological requirements, paving the way for new drug development.
Second, in the field of materials science, it also has important applications. It can be integrated into polymer materials through specific reactions, giving the materials unique photoelectric properties. In this way, it may be used to prepare organic Light Emitting Diodes (OLEDs), solar cells and other related materials, and optimize the charge transport and fluorescence emission properties of the materials through their structural characteristics, so as to improve the application efficiency of the materials in the field of optoelectronic devices.
Third, in the catalytic reaction system, it can be used as a ligand or participate in the catalytic cycle. With its electronic properties of boron atoms and pyridine rings, it cooperates with metal catalysts to change the activity and selectivity of the catalyst. In some coupling reactions, it can promote the reaction to proceed more efficiently and accurately, generate target products, and improve the efficiency and quality of organic synthesis reactions, which is of great significance in the process optimization of organic synthesis chemistry.

To prepare 1-benzyl-4- (4,4,5,5-tetramethyl-1,3,2-dioxyboron-heterocyclopentane-2-yl) -1,2,3,6-tetrahydropyridine, there are two common synthesis methods.
First, 1-benzyl-4-halo-1,2,3,6-tetrahydropyridine and diphenacol borate are used as starting materials. In the reaction system, palladium catalysts, such as palladium acetate, and ligands, such as tri-tert-butylphosphine, are added. A base such as potassium carbonate is used as an acid binding agent, and the reaction is heated and stirred in an organic solvent, such as toluene or dioxane. This reaction uses the cross-coupling mechanism of palladium catalysis, where halogen atoms are coupled with borate ester groups to obtain the target product. The advantage is that the reaction conditions are relatively mild and the yield is acceptable; however, the price of palladium catalysts is quite high, and the post-reaction treatment may require cumbersome separation steps.
Second, first prepare 4- (4,4,5,5-tetramethyl-1,3,2-dioxyboronheterocyclopentane-2-yl) -1,2,3,6-tetrahydropyridine, and then react with benzyl halide. The former can be obtained by the above-mentioned palladium catalytic coupling of 4-halo-1,2,3,6-tetrahydropyridine and diphenacol borate. Then, under basic conditions, such as cesium carbonate as a base, in N, N-dimethylformamide solvent, 4- (4,4,5,5-tetramethyl-1,3,2-dioxoboron heterocyclopentane-2-yl) -1,2,3,6-tetrahydropyridine undergoes nucleophilic substitution with benzyl halide to form the target product. This route has a little more steps, but the reaction selectivity or better in each step, and the selection of raw materials is more flexible.

1-Benzyl-4- (4,4,5,5-tetramethyl-1,3,2-dioxyboron heterocyclopentane-2-yl) -1,2,3,6-tetrahydropyridine, this is an organic compound. Looking at its structure, it contains benzyl, tetrahydropyridine ring and dioxyboron heterocyclopentane structure fragment. This structure gives the compound unique physical and chemical properties.
In terms of physical properties, usually such organic compounds with polycyclic structures are solid at room temperature because of their strong intermolecular forces. Its melting point may vary due to structural regularity and intermolecular interactions, and the strong intermolecular forces have a higher melting point. In terms of solubility, in view of its polar boroxyl heterocycles and non-polar benzyl and pyridine rings, it has good solubility in organic solvents, such as common chloroform, dichloromethane, etc., because some of its structures can interact with organic solvents to form van der Waals forces. However, its solubility in water is limited, because its non-polar part is large, and the interaction with water is weak.
When it comes to chemical properties, the boroxyl heterocycles in this compound have certain reactivity. Boron atoms are electron-deficient and can participate in a variety of organic reactions, such as the Suzuki coupling reaction, which is an important reaction for building carbon-carbon bonds. The nitrogen atom on the tetrahydropyridine ring has lone pairs of electrons and has a certain alkalinity, which can react with acids to form salts. The benzyl moiety also has high carbon-hydrogen bond activity at the benzyl position, and can undergo oxidation, substitution and other reactions under appropriate conditions. The various reactivity checking points of this compound make it have great potential for application in the field of organic synthesis, and can be used as a key intermediate to construct more complex organic molecular structures.

The price of 1 - Benzyl - 4 - (4, 4, 5, 5 - tetramethyl - 1, 3, 2 - dioxaborolan - 2 - yl) - 1, 2, 3, 6 - tetrahydropyridine in the market is geometric. However, the price of this compound is difficult to determine. The price of the compound often varies for many reasons.
One is related to purity. If the purity is very high, it is almost perfect, and the price is high; if the purity is slightly inferior, the price may be slightly reduced. For high purity, the difficulty of preparation and the huge labor cost all make the price high.
Second, it depends on supply and demand. If there are many people who want it, but there are few people who supply it, the price will rise; if the market is flooded and the supply exceeds the demand, the price will drop.
Third, the difference between manufacturers and sellers is also different. Well-known large factories, with excellent craftsmanship, rigorous quality control, and high product reliability, their price may be high; small factories, although the price may be low, the quality may vary.
Fourth, the amount of purchase also affects the price. If you buy in bulk, you may get a discount; if you buy a small amount, the price may be high.
Today in the market, I have not seen the actual price. If you want to know the exact number, you can consult the chemical raw material trading platform, reagent supplier, or negotiate with relevant sellers to obtain the actual price.

1-Benzyl-4- (4,4,5,5-tetramethyl-1,3,2-dioxyboron-heterocyclopentane-2-yl) -1,2,3,6-tetrahydropyridine, which is an important chemical substance in the field of organic synthesis. Its storage conditions are the key elements to maintain the stability and quality of the substance.
Because the compound may be sensitive to air and moisture, it should be stored in a cool, dry and well-ventilated place. Such an environment can prevent its properties from changing due to changes in humidity and temperature. To prevent it from reacting with oxygen and moisture in the air, it should be properly stored in a sealed container. Such as the use of glass bottles or metal cans, and ensure that the seal is tight, there is no risk of air and moisture intrusion.
If conditions permit, it can be stored in an inert gas environment, such as nitrogen atmosphere, which can further reduce the possibility of contact with active ingredients such as oxygen and extend the shelf life. And the storage temperature must also be strictly controlled. Generally speaking, a low temperature environment is more conducive to its storage. Generally, it can be placed in the refrigerator for refrigeration, and the temperature should be 2-8 ° C. However, it must not be generalized. For specific temperature settings, it is also necessary to refer to the detailed physical and chemical properties of the substance and related research data.
During storage, it is also necessary to avoid exposure to strong light. Due to light or photochemical reactions, the structure will change, which will affect its quality and performance. Therefore, the storage place should be selected in a dark place, or use light-shielding packaging materials.
The consideration of such various storage conditions is to ensure that 1-benzyl-4- (4,4,5,5-tetramethyl-1,3,2-dioxyboronheterocyclopentane-2-yl) -1,2,3,6-tetrahydropyridine remains stable during storage for subsequent experiments or production such as organic synthesis.