1-(4-Chloropyridine-2-yl)ethanone

The main use of 1- (4-cyanopyridine-2-yl) acetamide is a key intermediate in the field of organic synthesis. In the field of medicinal chemistry, it exhibits extraordinary functions. It can participate in the construction of many drug molecules through specific chemical reaction processes. For example, in the synthesis of some compounds with unique physiological activities, 1- (4-cyanopyridine-2-yl) acetamide is often used as a starting material, and through delicate reaction steps, it is gradually derived into drugs with therapeutic efficacy for specific diseases. It also has traces on the path of anti-cancer drug development. By ingeniously combining with other reagents, a specific chemical structure is constructed to target cancer cells, inhibit their proliferation and induce their apoptosis.
In the field of materials science, it also has applications that cannot be ignored. It can be chemically modified to make it an important cornerstone for the construction of new functional materials. For example, when preparing polymer materials with special electrical and optical properties, the specific functional groups introduced by 1- (4-cyanopyridine-2-yl) acetamide can significantly change the molecular arrangement and electron cloud distribution of the material, thereby endowing the material with unique properties such as fluorescence properties and conductivity regulation, and opening up a new direction for the development of new optoelectronic materials.
Furthermore, in the field of pesticide chemistry, as an intermediate, it helps to synthesize high-efficiency, low-toxicity and environmentally friendly pesticides. By rationally designing chemical reactions and incorporating them into the molecular structure of pesticides, the targeting and lethality of pesticides to pests can be enhanced, and the adverse effects on non-target organisms and the environment can be reduced, which is of great significance to promoting the development of green agriculture.

The synthesis method of 1- (4-cyanopyridine-2-yl) acetamide, although the ancient book "Tiangong Kaiwu" does not contain this specific chemical synthesis method, can draw inspiration from the wisdom of the ancients on material transformation and process operation, and deduce today's synthesis strategy with ancient thinking.
To synthesize 1- (4-cyanopyridine-2-yl) acetamide, you can think about it from the choice of raw materials and the reaction path. As far as raw materials are concerned, choose the one that is easy to obtain and has the best price. 4-cyanopyridine-2-yl related precursors may be derived from natural products or basic chemical raw materials. The ancients often used local materials in alchemy and pharmaceuticals, brewing and smelting, etc., and tried many times to find suitable materials. Today, it is also necessary to follow this principle and carefully investigate the characteristics and sources of raw materials.
The reaction path design is simple and not complicated. In ancient methods, heating, mixing, extraction and other means are mostly used to promote the conversion of substances. In the synthesis of 1 - (4-cyanopyridine-2-yl) acetamide, the reaction can be initiated by heating, so that the raw materials can interact under specific conditions. For example, the ancients used alchemy to control the reaction process by temperature, but now precise temperature control equipment can ensure that the reaction is carried out at a suitable temperature.
Furthermore, the choice of solvent is also crucial. In ancient brewing, water was a common medium because it was easy to obtain and could assist in the reaction. When synthesizing this compound, a solvent with good solubility to the raw material and product and no interference with the reaction was selected to create a suitable reaction environment.
In addition, the use of catalysts may accelerate the reaction and increase the yield. Although the ancients did not know the name of the catalyst, they skillfully used tillers and other substances in fermentation and other processes, which actually exerted catalytic effect. Today's synthesis of 1- (4-cyanopyridine-2-yl) acetamide should also seek high-efficiency catalysts to optimize the reaction conditions.
In summary, the synthesis of 1- (4-cyanopyridine-2-yl) acetamide can refer to the wisdom of the ancients in material transformation, and carefully design from the aspects of raw materials, reaction paths, solvents, catalysts, etc. to achieve the purpose of synthesis.

1 - (4 -cyanopyridine-2 -yl) acetamide, this is an organic compound. Its physical properties are many, as follows:
In terms of appearance properties, it is mostly white to off-white crystalline powder under normal conditions, with fine texture and uniform color in terms of eyesight. This form is easy to store, transport and subsequent use. Because it is stable in conventional environments, it is not easy to affect the properties due to morphological changes.
In terms of melting point, it is about [X] ° C. As a key physical property, the melting point is of great significance for the identification and purification of this compound. When the temperature rises to the melting point, the substance changes from solid to liquid, and the purity of the compound can be judged. The higher the purity, the closer the melting point is to the theoretical value, and the narrower the melting range. In terms of solubility, it has a certain solubility in common organic solvents such as methanol, ethanol, and dichloromethane. In methanol, because the polarity of methanol is similar to the partial structure of the compound, it can be dissolved to a certain extent according to the principle of "similar miscibility", and the solution is clear and transparent; in the aqueous phase, the solubility is relatively small, because its molecular structure contains hydrophobic groups, which reduces its affinity with water. This solubility characteristic plays a significant role in the process of organic synthesis, separation and purification, and can be used to select suitable solvents for reaction and purification. The density of
is about [X] g/cm ³, which reflects the unit volume mass of the substance. It is an important reference in terms of converting mass and volume, and determining the position of the substance in the mixed system. In the transportation or storage of chemical production pipelines, the density depends on the specifications and conditions of the required equipment.
In terms of stability, it is quite stable at room temperature and pressure, and it is not easy to decompose and polymerize by itself. However, in case of specific chemical substances such as strong oxidizing agents, strong acids, and strong bases, chemical reactions may cause structural changes. When storing and using, it is necessary to avoid contact with such substances, and choose suitable storage conditions, such as in a cool, dry, well-ventilated place, away from fire sources and incompatible substances.

1 - (4 -cyanopyridine-2 -yl) acetamide, its chemical properties are as follows:
This substance contains an amide group and a cyano group. Among the amide groups, the carbonyl group has certain electrophilicity, and the nitrogen atom has lone pair electrons, which can participate in a variety of reactions. Because the carbonyl group is conjugated with the nitrogen atom, the amide is relatively stable. Under the catalysis of acid or base, the amide can undergo hydrolysis reaction. Hydrolysis under acidic conditions produces carboxylic acids and ammonium salts; when alkaline, carboxylate and ammonia are obtained.
Cyanyl groups are active in nature, with nucleophilic and electrophilic properties. Nucleophilic addition can be performed, like reacting with Grignard reagents, first adding to generate imine salts, and then hydrolyzing to obtain ketones. Cyanyl groups can also be reduced, and strong reducing agents such as aluminum lithium hydride can be reduced to amine groups; after gentle reduction, aldehyde groups can be obtained.
This compound is widely used in the field of organic synthesis because it contains multiple reactive groups. It can be used as an intermediate to build more complex organic molecules. For example, using it as a raw material, through a series of reactions such as amide hydrolysis and cyanotransformation, organic compounds with biological activity or special functions can be synthesized, which have potential application value in pharmaceutical chemistry, materials science, etc.

The price range of 1- (4-cyanopyridine-2-yl) acetamide in the market is difficult to determine. The price is determined by many factors, such as quality, supply and demand, difficulty in preparation, and intense market competition.
Looking at the quality end, if its purity is high, there are few impurities, and it meets the strict standards of fine chemical or pharmaceutical research and development, the price will be high. Due to high-quality products, the preparation process often requires exquisite craftsmanship and strict quality control, and the cost is high.
Supply and demand are also key. If the market demand for 1 - (4-cyanopyridine-2-yl) acetamide is strong, but the supply is limited, the price will rise; conversely, if the supply exceeds the demand, the price may drop.
Furthermore, the difficulty of preparation has a great impact. If its synthesis requires complex steps, rare raw materials or special reaction conditions, the cost will rise, resulting in higher prices.
The state of market competition cannot be ignored. When there are many manufacturers producing this compound in the market, in order to compete for a share, they may compete with the price, which will lower the overall price; if the market is almost monopolized, or only a few manufacturers can produce it, the price may be high.
Overall, in the chemical raw material market, the price of 1- (4-cyanopyridine-2-yl) acetamide may range from a few hundred to several thousand yuan per kilogram, but this is only a rough estimate. The actual price needs to be confirmed according to the specific transaction scenarios and purchase quantities.