1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,4-dihydropyridine-3-carboxamide

(The naming of this compound is more complicated, and the following is the process of step-by-step analysis of its structure)
View this naming "1- ((2R, 3R, 4S, 5R) -3,4-difluoro-5- (fluoromethyl) tetrahydrofuran-2-yl) -1,4-dihydropyridine-3-acetonitrile", and its structure can be analyzed as follows.
First, "1,4-dihydropyridine-3-acetonitrile" indicates that the core framework of the compound is a dihydropyridine structure, with hydrogen atoms at the 1,4 positions of the pyridine ring and acetonitrile groups at the 3 positions. That is, there is a nitrogen-containing six-membered unsaturated ring, the 1 and 4 positions on the ring are hydrogen, and the 3 positions are connected to the -CH ³ CN group through a carbon-carbon bond.
Furthermore, the "1- ((2R, 3R, 4S, 5R) -3,4-difluoro-5- (fluoromethyl) tetrahydrofuran-2-yl) " section describes the connection of a tetrahydrofuran derivative at the 1 position of 1,4-dihydropyridine. The tetrahydrofuran ring has a specific three-dimensional configuration (2R, 3R, 4S, 5R), and fluorine atoms are connected at the 3rd and 4th positions, fluoromethyl (-CH -2 F) is connected at the 5th position, and the 2nd position is connected to the 1st position of 1,4-dihydropyridine as a connection point.
Overall, the structure of the compound is based on 1,4-dihydropyridine as the core, acetonitrile at the 3rd position, and tetrahydrofuran groups with specific three-dimensional configurations and substituents at the 1st position, presenting a complex and unique chemical structure. Its specific spatial structure has a specific three-dimensional arrangement due to the three-dimensional configuration (2R, 3R, 4S, 5R), and different substituents endow it with unique physical and chemical properties.

1 - ((2R, 3R, 4S, 5R) -3,4-difluoro-5- (fluoromethyl) tetrahydrofuran-2-yl) -1,4-dihydropyridine-3-formate ethyl ester is an organic compound. The relevant physical properties of this substance are as follows:
It is usually a solid or viscous liquid, and has a certain melting point and boiling point due to its specific structure and functional groups. The specific value of the melting point depends on the intermolecular force, lattice energy, etc., and may vary under different preparation and purification conditions. Generally speaking, fluorine-containing groups change the intermolecular force, resulting in different melting points from fluorine-free analogs. The boiling point is affected by molecular weight and intermolecular forces. The compound contains multiple polar groups, and there are strong forces between molecules, such as hydrogen bonds, van der Waals forces, etc. Compared with non-polar compounds of the same molecular weight, the boiling point is higher.
The compound has a certain solubility. Because it contains polar fluorine groups and ester groups, it has a certain solubility in polar organic solvents such as methanol, ethanol, and dichloromethane. The large electronegativity of fluorine atoms enhances the polarity of molecules and makes it easier to interact with polar solvent molecules; ester groups can form hydrogen bonds or van der Waals forces with solvents, which helps to dissolve. However, in non-polar solvents such as n-hexane and cyclohexane, the solubility is low, because its non-polar structure is difficult to interact effectively with non-polar solvent molecules. < Br >
In terms of density, the density may be different from that of water due to molecular composition and structure. The relative mass of fluorine atoms in the molecule is large, which increases the overall density. The specific density value can be accurately determined by experiments, which is related to the way of molecular accumulation and atomic mass distribution.
Appearance is often white to light yellow, and the color is affected by impurities and crystalline state. If the impurities are not removed during the preparation process, or the appearance is affected by the color development of impurities; different crystalline states, such as differences in crystal form, will also make the appearance slightly different.

(1- ((2R, 3R, 4S, 5R) -3,4-difluoro-5- (fluoromethyl) tetrahydrofuran-2-yl) -1,4-dihydropyridine-3-acetate) The main use is to play a key role in the field of medicinal chemistry. This compound plays an important role in drug development, especially in the process of drug creation for specific diseases, showing unique medicinal value.
Its structural properties give it the ability to interact with specific targets in organisms. In the exploration of the treatment of some diseases, scientists have found that it can precisely bind to certain key biomacromolecules, which has an impact on related physiological and pathological processes. For example, in the field of neurological diseases, it may be able to modulate the transmission of neurotransmitters and improve the transmission of nerve signals by binding to specific receptors on the surface of nerve cells, thus providing new possibilities for the treatment of neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease.
At the same time, the compound also has potential applications in the development of drugs for cardiovascular diseases. It may regulate the rhythm of the heart and the tension of blood vessels by acting on ion channels or signal transduction pathways in the cardiovascular system, thus providing innovative drug solutions for the treatment of cardiovascular diseases such as hypertension and arrhythmia.
In addition, in the field of anti-tumor drug research and development, due to its unique structure and activity, it may interfere with key processes such as the proliferation, invasion and metastasis of tumor cells, which brings hope for the innovation of tumor therapeutic drugs. In short, this compound has great application potential in the drug development direction of various diseases due to its special structure, providing new ways and strategies for conquering various difficult diseases.

To prepare 1- ((2R, 3R, 4S, 5R) -3,4-difluoro-5- (fluoromethyl) tetrahydropyran-2-yl) -1,4-dihydropyridine-3-formate ethyl ester, there are various methods.
First, pyran derivatives containing suitable substituents can be started. First, a pyran compound with the (2R, 3R, 4S, 5R) configuration containing 3,4-difluoro and 5- (fluoromethyl) was found, and a series of reactions, such as modifying the pyran ring under appropriate conditions, were carried out to introduce the functional group required to connect to the pyridine ring. Then, with suitable reagents and reaction conditions, the pyran derivative was combined with the pyridine-related intermediate. In this process, the reaction temperature, time and reagent dosage need to be finely adjusted to make the reaction proceed in the direction of the target product.
Second, the pyridine derivative can be considered as the starting material. First, the pyridine ring is specially modified to introduce the basic structure of 1,4-dihydropyridine-3-ethyl formate. Then, through selective reactions, (2R, 3R, 4S, 5R) -3,4-difluoro-5- (fluoromethyl) tetrahydropyran-2-yl moiety is introduced at specific positions in the pyridine ring. This path requires highly selective reactions, such as regioselectivity and stereoselectivity, to ensure that the configuration and structure of the product are accurate.
Third, a step-by-step construction strategy can also be adopted. First, the pyran fragment and the pyridine fragment containing the desired configuration are synthesized separately, and then the two are spliced into the target product through a suitable ligation reaction. This strategy requires precise control of the synthesis of each fragment to ensure the purity and configuration of the fragment are correct. And during the ligation reaction, appropriate reaction conditions and ligation reagents should be selected to make the reaction proceed efficiently, while ensuring the stability and purity of the product.
The above methods have their own advantages and disadvantages. Factors such as the selection of starting materials, the control of reaction conditions, and the separation and purification of the product need to be carefully considered before the most suitable method can be selected to obtain the target product with high yield and high purity.

I look at this question, which is a difficult problem related to organic chemistry. It involves the naming of complex compounds and related reactions.
First of all, the nomenclature of ((2R, 3R, 4S, 5R) -3,4-difluoro-5- (fluoromethyl) tetrahydrofuran-2-yl) -1,4-dihydropyridine-3-carboxylic acid is a fine and rigorous chemical nomenclature, which depends on the stereochemical configuration (R, S logo) and the position and type of each group.
As for the adverse reactions related to this compound, in organic chemistry, fluorine-containing groups may affect the reactivity and selectivity. The fluorine atom has strong electronegativity, which can change the electron cloud density of the adjacent chemical bonds. For example, in the nucleophilic substitution reaction, the presence of fluoromethyl groups or the reaction check point electron cloud density decreases, hindering the attack of nucleophilic reagents. In the redox reaction, the fluorine-containing structure may affect the oxidation state stability of the compound, causing the reaction path to change.
In dihydropyridine compounds, the nitrogen heterocyclic structure has a certain electron conjugation effect. 1,4-dihydropyridine-3-formic acid part, the carboxyl group is acidic, and can participate in acid-base reactions. Under different pH environments, its existence form or change affects the overall properties and reactivity of the compound.
The three-dimensional configuration (2R, 3R, 4S, 5R) of the compound also has an important influence on the reaction. Chiral centers can enable the compound to selectively interact with chiral reagents in asymmetric synthesis reactions to generate products of specific configurations. If there are chiral catalysts or chiral substrates in the reaction system, the (2R, 3R, 4S, 5R) configuration or guide the reaction in a specific direction will affect the optical purity and three-dimensional chemical purity of the product.
In short, due to the complex structure of this compound, its group characteristics and three-dimensional configuration will have many effects on the reaction in various organic reactions. All factors need to be carefully considered in order to understand the full picture of its related adverse reactions.