1-(2-fluorobenzyl)-1h-pyrazolo(3,4-b)pyridine-3-carboximidamide hydrochloride

1- (2-fluorobenzyl) -1H-pyrazolo (3,4-b) pyridine-3-formamidine hydrochloride has the following chemical structure:
The core structure of this compound is pyrazolo (3,4-b) pyridine, which is connected to a 2-fluorobenzyl group at the 1st position and a formamidine group at the 3rd position, and exists in the form of hydrochloride as a whole.
The structure of pyrazolo (3,4-b) pyridine is formed by fusing a pyrazole ring with a pyridine ring. The nitrogen atom on the pyrazole ring and the nitrogen atom on the pyridine ring endow the structure with certain basicity and unique electronic characteristics. 2-Fluorobenzyl is connected to the first position of the pyrazole ring. The introduction of fluorine atoms will affect the physicochemical properties of the molecule such as electron cloud distribution and lipophilicity, while the benzyl part increases the hydrophobicity and steric resistance of the molecule. The formamidine group at the 3rd position contains multiple nitrogen atoms, which can participate in the formation of hydrogen bonds and other interactions, which may have an important impact on the biological activity of the compound and the ability to bind to the target. The hydrochloride form alters the solubility of the compound, usually increasing its solubility in water, which is conducive to transportation and metabolism in living organisms.

1- (2-fluorobenzyl) -1H-pyrazolo (3,4-b) pyridine-3-formamidine hydrochloride has a wide range of uses. In the field of pharmaceutical research and development, it can be used as a key intermediate to help create new antimalarial drugs. Malaria is a serious threat to human health. This compound may inhibit the growth and reproduction of malaria parasites after specific chemical modification and structural optimization, providing a new and effective way for malaria treatment.
In the field of pesticides, it may have unique biological activities and can be developed into new insecticides or fungicides. Taking pesticides as an example, they play a role in the nervous system or physiological and metabolic processes of some pests, effectively repel pests, and are relatively friendly to the environment, reducing the pollution and harm caused by traditional pesticides.
In the field of materials science, or can participate in the synthesis of functional materials. For example, by compounding with specific polymers, the material is endowed with special electrical, optical or mechanical properties, and is widely used in the manufacture of electronic devices, optical instruments, etc.
In organic synthetic chemistry, it is an important building block for the construction of complex organic molecules. With its unique molecular structure and reactivity, chemists can use a variety of chemical reactions to expand the molecular skeleton, derive a wide range of compounds with potential application value, and inject vitality into the development of organic synthetic chemistry.

1- (2-fluorobenzyl) -1H-pyrazolo (3,4-b) pyridine-3-formamidine hydrochloride, this is an organic compound. Its physical properties are crucial, and it is related to many properties and uses of this compound.
Looking at its properties, it may be white to off-white crystalline powder under normal circumstances. This feature is easy to identify and distinguish, and is of great significance in laboratory and industrial production. For example, observing the color and morphology of the powder can preliminarily determine the purity of the product.
Melting point is also an important physical property. After experimental determination, its melting point is in a specific temperature range, which is indispensable for compound identification and purity evaluation. Knowing the melting point, the melting point measurement experiment can be used to determine whether the obtained compound is the target. If the measured melting point matches or is similar to the literature value, it indicates that the purity is high; if the deviation is large, it may contain impurities.
In terms of solubility, the compound has different solubility in common organic solvents such as methanol, ethanol, dichloromethane, etc. In methanol, it can exhibit good solubility under certain conditions and can dissolve to form a uniform solution. This property is widely used in organic synthesis and drug development. For example, when preparing pharmaceutical preparations containing this compound, a suitable solvent can be selected according to its solubility to achieve the desired dosage form.
In addition, its physical properties such as density and boiling point are also of great significance for the study of its properties and applications. Density data can be used for precise calculation in mass and volume conversion operations, and boiling point information can provide theoretical basis for compound separation and purification. In conclusion, the physical properties of 1- (2-fluorobenzyl) -1H-pyrazolo (3,4-b) pyridine-3-formamidine hydrochloride lay the foundation for its application in scientific research, industrial production and other fields.

To prepare 1- (2-fluorobenzyl) -1H-pyrazolo (3,4-b) pyridine-3-formamidine hydrochloride, the method is as follows:
First take 2-fluorobenzyl halide, and 1H-pyrazolo (3,4-b) pyridine-3-formonitrile in a suitable solvent, such as dimethylformamide (DMF), add a base, such as potassium carbonate, heat and stir. The base can assist the nucleophilic substitution of the halide with the nitrile, so that 2-fluorobenzyl is attached to pyrazolopyridinitrile to obtain 1- (2-fluorobenzyl) -1H-pyrazolo (3,4-b) pyridine-3-formonitrile.
Then, the formonitrile product is moved to another reaction system, and a suitable reducing agent, such as lithium aluminum hydride (LiAlH), is added, and anhydrous ethyl ether is used as a solvent. The formonitrile is reduced to formamidine.
Finally, the reaction solution is added with hydrochloric acid to make formamidine hydrochloride, crystallized, filtered, and dried to obtain 1- (2-fluorobenzyl) -1H-pyrazolo (3,4-b) pyridine-3-formamidine hydrochloride. Each step of the reaction requires temperature control and control, and pay attention to the amount of reagents to achieve better yield and purity.

1- (2-fluorobenzyl) -1H-pyrazolo (3,4-b) pyridine-3-formamidine hydrochloride, this compound is used in the field of pharmaceutical chemical industry, or has potential pharmaceutical activity, but the current market prospect is complicated.
In the frontier field of new drug research and development, there is an urgent need for innovative drugs, and compounds with novel structures and unique activities are highly concerned. If this compound is confirmed to have clear biological activity and mechanism of action, and can show significant effects on specific disease targets, such as inhibitory or regulatory effects on certain targets such as cancer and nervous system diseases, it will have great potential in the new drug development market. Many pharmaceutical companies and scientific research institutions may be willing to invest resources in in-depth research and development, which is expected to give birth to innovative drugs, and then open up a broad market space.
However, from the perspective of market competition, the competition in the field of pharmaceutical research and development is extremely fierce. Many pharmaceutical companies and scientific research teams around the world are exploring new drugs, and the research and development of compounds with similar structures or mechanisms of action may already be in progress. If other institutions complete the research and development and launch of this product before this product, the marketing activities of this product will face huge challenges. And the research and development process of new drugs is long, and it needs to go through multiple stages such as pre-clinical research and clinical trials. The cost is high, and the risk of failure is also high. If there are technical problems, safety problems, etc. in the development process of this product, the market
Furthermore, market access and regulatory policy factors also have a great impact on the market prospects of this product. Drug marketing needs to meet strict regulatory requirements and approval processes. If this product cannot meet relevant standards, it is difficult to enter the market for sale. Different countries and regions have different regulations and policies, which also increases the complexity of marketing activities.
Overall, the market prospects of 1- (2-fluorobenzyl) -1H-pyrazolo (3,4-b) pyridine-3-formamidine hydrochloride depend on factors such as research and development progress, competition situation, regulations and policies. Although there are potential opportunities, there are also many challenges and uncertainties.