1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile

1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-formonitrile has a wide range of uses. In the field of medicinal chemistry, this compound is often a key intermediate for the creation of new drugs. Due to its unique chemical structure, it can interact with specific biological targets and assist in the development of drugs for specific diseases, such as anti-tumor, antiviral and other drugs.
In the field of materials science, it is also possible. With its special molecular structure, it may be able to participate in the synthesis of materials with special properties, such as optical materials, electrical materials, etc., endowing materials with novel physical and chemical properties to meet the needs of different application scenarios.
Furthermore, in the field of organic synthetic chemistry, 1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-formonitrile is often used as an important raw material. Through various organic reactions, organic compounds with more complex structures and unique functions are derived, expanding the variety and application of organic compounds. This compound has important value in many scientific fields and is an important substance to promote the development of related fields.

The synthesis of 1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-formonitrile involves many organic chemical synthesis techniques. One method involves nucleophilic substitution of 2-fluorobenzyl halide and 1H-pyrazolo [3,4-b] pyridine-3-formonitrile in the presence of a base. In this process, the base can take away the active hydrogen of 1H-pyrazolo [3,4-b] pyridine-3-formonitrile to generate carboanion, which in turn replaces the halogen atom of 2-fluorobenzyl halide to form the target product.
Another method, or a suitable pyridine derivative and a fluorobenzyl reagent, can be prepared by multi-step reaction. Initially, the pyridine derivative is introduced into the pyrazole ring through a specific reaction, and then the nitrile reaction is carried out to introduce the formonitrile group. Finally, by nucleophilic substitution or other coupling reaction, 2-fluorobenzyl is connected to obtain 1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-formonitrile.
The control of reaction conditions is crucial. Temperature, reaction time, and the proportion of reactants all affect yield and purity. It is often necessary to optimize the experimental conditions to find the best conditions. And the choice of organic solvent should not be ignored. It needs to have good solubility to the reactants and do not side-react with the reactants and products. The type and dosage of bases also affect the reaction process. Strong basic substances or accelerate the reaction, but may cause side reactions to increase. Therefore, when synthesizing, various factors must be considered comprehensively and careful operation should be carried out to achieve the purpose of efficient synthesis of 1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-formonitrile.

1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-formonitrile is one of the organic compounds. Its physical and chemical properties are particularly important, and it is related to many uses and reactions of this compound.
First of all, the physical properties. This substance is at room temperature, or in a solid state, but the exact physical form depends on the purity and surrounding environmental conditions. Its melting point is a key parameter in organic synthesis and purity identification. It is rare that there is no exact data to clarify its specific melting point value, but the melting point of similar compounds is mostly in a specific temperature range, which can be used as a reference. In addition, its boiling point is also an important physical property, but it lacks accurate values. Its solubility in various solvents is also a key point of concern. In organic solvents such as ethanol and dichloromethane, it may have a certain solubility, because the molecular structure contains specific functional groups, which interact with organic solvent molecules. However, in water, because of its strong molecular hydrophobicity, or poor solubility.
As for chemical properties, this compound contains cyanyl, pyrazolopyridine ring and benzyl structure. Cyanyl has high reactivity and can participate in a variety of chemical reactions, such as hydrolysis. Under acidic or basic conditions, cyanyl can be converted into carboxyl or amide groups, which is a common transformation in organic synthesis. Pyrazolopyridine ring has aromatic properties, which endows the compound with certain stability, and the nitrogen atom on the ring can be used as a nucleophilic check point to participate in nucleophilic substitution reactions. In the benzyl structure, the benzyl carbon-hydrogen bond has certain activity, and under appropriate conditions, reactions such as oxidation and substitution can occur. At the same time, the existence of 2-fluorine atoms affects the distribution of molecular electron clouds, which in turn affects the reactivity and selectivity of the compound, or changes the ortho-site or para-site reactivity. In the electrophilic substitution reaction, the localization effect of fluorine atoms will play a key role.

I don't know if 1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-formonitrile is in the market price range. This compound is very common, and its price is easily influenced by many factors.
First, the difficulty of preparation is the key. If the synthesis requires complicated steps, special raw materials or harsh reaction conditions, the cost will be high, and the price will also rise. Just like some compounds containing rare elements or complex structures, the synthesis is like climbing the wall, and the price is naturally high.
Second, the amount of demand has a great impact. If there is strong demand in the field of scientific research or the pharmaceutical industry, the supply is in short supply, and the price will rise; if it is only needed for niche research, the demand is few, and the price may be relatively easy.
Third, different suppliers also lead to price differences. Large suppliers may be able to offer more favorable prices due to economies of scale; small suppliers may have higher prices due to cost considerations.
Fourth, the market fluctuates like a cloud. Raw material prices rise and fall, changes in policies and regulations, and fluctuations in the economic situation can all make their prices fluctuate.
To know the exact price range, you can consult chemical product suppliers, chemical trading platforms, or consult relevant industry reports to obtain accurate figures.

1 - (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-formonitrile, there are many related manufacturers of this compound. In the chemical industry, many large enterprises and fine chemical manufacturers are involved in the production of this compound.
If there are many domestic manufacturers focusing on the research and development of characteristic intermediates, they can produce high-quality this compound with advanced synthesis technology and strict quality control. They are often deeply involved in the pharmaceutical and pesticide intermediates market to meet the demand for high-quality raw materials in downstream industries.
There are also some internationally renowned chemical companies with global production bases. With strong R & D strength and wide market channels, they are also the main producers of 1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-formonitrile. Its production process may be more advanced, and the product specifications are more diverse, which can adapt to different customer requirements.
In addition, some emerging chemical technology companies, although the scale may not be as large as large enterprises, have also emerged in the field of chemical compound production with innovative technologies and flexible operation models. They often focus on cutting-edge technologies such as green synthesis and high-efficiency catalysis, injecting new vitality into the development of the industry.
In summary, 1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine-3-formonitrile manufacturers are widely distributed, covering various domestic and foreign enterprises with various scales and technical characteristics, together forming a rich and diverse production pattern of this product.