(卤)-Hydroxymethyl Methyl 4-(2,3-Dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate Butyrate (Ester)

This is the chemical structure of (γ) -hydroxymethyl, methyl 4- (2,3-dichlorophenyl) -2,6-dimethyl-1,4-dihydro-3,5-butyl pyridine dicarboxylate (ester). Looking at its name, it can be seen that this compound is composed of many parts.
(γ) -hydroxymethyl is a group with a hydroxyl group in the structure and is connected to the main chain in a specific position. As a common alkyl group, methyl participates in the construction of the overall structure. 4- (2,3-dichlorophenyl), indicating that there is a 2,3-dichloro-substituted phenyl group attached to the 4th position of the pyridine ring. This phenyl structure has specific chemical activity due to the substitution of chlorine atoms. 2,6-Dimethyl indicates that the 2 and 6 positions of the pyridine ring are each connected with a methyl group, which affects the molecular spatial configuration and chemical properties. 1,4-Dihydro-3,5-pyridinedicarboxylic acid, it is determined that the main ring is a dihydro-pyridine structure and has two carboxyl groups at 3,5 positions, and these two carboxyl groups form ester groups respectively. One carboxyl group forms an ester with methyl group, and the other carboxyl group forms a butyl ester with butanol. The complex structure of this compound, the interaction of various parts determines its unique chemical, physical properties and reactivity.

The physical properties of (γ) -hydroxymethylmethyl 4- (2,3-dichlorophenyl) -2,6-dimethyl-1,4-dihydro-3,5-butyl pyridinedicarboxylate (ester) are crucial and related to many practical applications.
Its appearance may be in a specific form, or in a crystalline state, or in a powder state, depending on the preparation and environment. Looking at its color, it may be colorless and transparent, or slightly yellowish, and the difference in purity is due to the change in color.
In terms of solubility, this substance exhibits unique properties in specific organic solvents. In alcoholic solvents, such as ethanol, or with a certain solubility, by means of intermolecular forces, it fuses with the solvent. In water, its solubility is poor, and it is difficult to form effective interactions with water molecules due to its molecular structural properties. The melting point of
is also one of the important physical properties. The melting point of this substance has been accurately determined and is a specific temperature value. At this temperature, the substance changes from a solid state to a liquid state, and this process is accompanied by energy absorption and changes in molecular arrangement. The determination of the melting point is of great significance for the temperature control during its purification, identification and application. The boiling point of
is also a key consideration. When a specific boiling point temperature is reached, the substance is converted from a liquid state to a gas state. The definition of this temperature is indispensable in processes such as distillation and separation, and is related to the effective separation and purification of the substance.
Density is the mass per unit volume, reflecting its compactness. The determination of the density of this substance provides an important basis for the study of its storage, transportation and behavior in a specific system.
The above physical properties are interrelated and affect each other. The research, production and application of (γ) -hydroxymethylmethyl 4- (2,3-dichlorophenyl) -2,6-dimethyl-1,4-dihydro-butyl-3,5-pyridinedicarboxylate (ester) are essential to help researchers and producers fully understand the properties of this substance in order to achieve optimal use and treatment results.

(γ) -hydroxymethylmethyl 4- (2,3-dichlorophenyl) -2,6-dimethyl-1,4-dihydro-3,5-butyl pyridinedicarboxylate (ester) This substance has a wide range of uses.
Its chemical structure is unique, and it can be used as a key intermediate in the field of pharmaceutical creation. Pharmaceutical research and development often requires delicate compounds as bases, which are transformed in a series to form drugs with specific pharmacological activities. The structural characteristics of this compound may enable it to play an important role in the construction of drug molecules, assisting researchers in creating new drugs for specific diseases, such as anti-cancer and anti-infection genera. < Br >
In the field of materials science, it also has its uses. Material synthesis often relies on compounds with special structures to give materials novel properties. This ester compound may participate in the polymerization reaction of materials, endowing materials with good thermal stability, mechanical properties, etc., and is used in high-tech materials, such as special materials used in aerospace and electronic equipment.
Furthermore, in the field of organic synthesis chemistry, it can be used as a reaction substrate. Through various organic reactions, a variety of complex compounds can be derived, enriching the library of organic compounds, providing opportunities and possibilities for organic synthesis chemists to explore new reaction paths and expand the chemical space. In short, this compound has potential value in many fields, and is waiting for Fang family to explore and make good use of it.

To prepare (γ) -hydroxymethyl, methyl 4- (2,3-dichlorophenyl) -2,6-dimethyl-1,4-dihydro-3,5-butyl pyridine dicarboxylate (ester), the method is as follows:
First take an appropriate amount of 4- (2,3-dichlorophenyl) -2,6-dimethyl-1,4-dihydro-3,5-pyridine dicarboxylic acid and place it in the reactor. An appropriate amount of organic solvent, such as dichloromethane or N, N-dimethylformamide, is pre-placed in the kettle to help the reactants dissolve and promote the reaction to be uniform.
Then take the metered methanol and butanol and add them to the kettle in a certain proportion. During this process, the temperature must be precisely controlled and can be maintained between 20 and 30 degrees Celsius to ensure the stable participation of alcohols in the reaction.
Then, slowly add an appropriate amount of concentrated sulfuric acid as a catalyst. Concentrated sulfuric acid has strong catalytic properties and can accelerate the esterification reaction process. When adding, it must be injected slowly and stirred fully to prevent local overheating from causing side reactions.
When the catalyst is added completely, heat up to 60 to 80 degrees Celsius. This temperature range is conducive to the efficient esterification reaction. During the reaction, continue to stir to make the reactants fully contact. After several hours of reaction, the reaction progress was monitored by thin-layer chromatography or gas chromatography. When the raw material peak was significantly reduced and the product peak reached the expected ratio, the reaction could be regarded as nearly complete.
After the reaction is completed, the reaction liquid is cooled to room temperature, and then an appropriate amount of saturated sodium bicarbonate solution is poured into it to neutralize the residual sulfuric acid. At this time, bubbles can be seen escaping, which is like acid-base neutralization. After neutralization, separate the liquid and take the organic phase.
The organic phase is dried with anhydrous sodium sulfate, except for the water in it. After that, the organic solvent is removed by vacuum distillation to obtain a crude product. The crude product can be purified by column chromatography or recrystallization to obtain pure (γ) -hydroxymethyl, methyl 4- (2,3-dichlorophenyl) -2,6-dimethyl-1,4-dihydro-3,5-butyl pyridinedicarboxylate (ester).
This preparation method requires attention to the conditions of each step during operation, and strict control of temperature, material ratio and reaction process to obtain the ideal product.

(γ) -hydroxymethyl, methyl 4- (2,3-dichlorophenyl) -2,6-dimethyl-1,4-dihydro-3,5-butyl pyridinedicarboxylate (ester) When using this product, many matters need to be paid attention to.
First, it is related to the storage method. Because of its nature, it may be special, when placed in a dry and cool place, away from fire sources and strong oxidants. If the storage environment is not good, such as humid and hot, or adjacent to inappropriate materials, it may cause chemical reactions to change its properties and affect the use effect.
Second, when taking it, measure it with a precise measuring tool. Because it may be a fine chemical, the amount of dosage has a great impact on the reaction result or application effect. If the dosage is too small, it is difficult to achieve the desired effect; if the dosage is too large, it will not only be wasted, but may also lead to other adverse consequences, such as excessive reaction and excess impurities.
Third, the operating environment also needs to be paid attention to. It should be used in a well-ventilated place. If it is used in a closed space, its volatile gas may be harmful to the human body, and some volatile components may be flammable and explosive. During operation, direct contact with the skin and eyes should also be avoided. If it is inadvertently touched, it is necessary to rinse with a large amount of water immediately and seek medical attention according to the specific situation.
Fourth, it is also crucial to know its chemical properties. When mixed with different substances, it is necessary to clarify whether Before compatibility with other chemical reagents, it is necessary to check the relevant information or conduct a small test first to prevent violent reactions from occurring and endangering safety.