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What is the chemical structure of (±)-α-( 2- (diisopropylamino) ethyl) -α-phenyl-2-pyridyl acetamide phosphate (1:1)?
This inquiry is about the chemical structure of (±) -α -( 2 - (diisopropylaminoformyl) ethyl) -α-phenyl-2 - to its acetylglycine anhydride (1:1). This is a rather specialized chemical field problem, let me elaborate.
In the analysis of chemical structure, it is necessary to clarify the composition and connection of each part of the group. First, (±) indicates that the compound has optical isomers, that is, enantiomers, whose spatial structure is mirror-symmetrical but cannot completely overlap. The substituent at the α-position indicates the connection status of the group at a specific position. " ( 2 - (diisopropylaminoformyl) ethyl) ", this part reveals an ethyl structure containing diisopropylaminoformyl, in which diisopropylaminoformyl is formed by connecting diisopropylaminoformyl to formyl, and ethyl acts as a connection bridge. α-phenyl, indicating that there is also a phenyl group attached to the α-position, and phenyl is the group remaining after removing a hydrogen atom from the phenyl ring.
Furthermore," 2-to its acetylglycine anhydride (1:1) ", which means that the acetylglycine anhydride part is bound to the previous structure in a ratio of 1:1. Acetyl glycine anhydride is formed by the dehydration and condensation of acetyl groups and glycine to form an anhydride structure. The anhydride structure is obtained by removing a molecule of water from two-molecule carboxylic acids, and has unique chemical properties and reactivity.
Overall, the chemical structure of this compound is quite complex, and each group is connected to each other to jointly determine its physical and chemical properties. The precise determination of its structure is of crucial significance for the study of the synthesis, reaction mechanism and potential biological activities of the compound. The complete chemical structure of (±) -α -( 2 - (diisopropylaminoformyl) ethyl) -α-phenyl-2 - to its acetylglycine anhydride (1:1) can be clearly delineated through the analysis and integration of each partial group.
What are the pharmacological effects of (±)-α-( 2- (diisopropylamino) ethyl) -α-phenyl-2-pyridyl acetamide phosphate (1:1)?
What is the pharmacological effect of (±) -α -( 2 - (diisopropylaminoformyl) ethyl) -α-phenyl-2 -isobutylamide urea anhydride (1:1)?
This medicine is a strange prescription with multiple pharmacological effects. First, it can regulate the circulation of qi and blood. Personal qi and blood are expensive to travel unimpeded, if there is stagnation, there will be many diseases. This medicine can dredge the qi and make the qi and blood smooth, just like the spring breeze blowing, the ice and snow melt, and the meridians are restored. Second, it can be adjusted and the functions of the viscera. The viscera perform their respective duties and cooperate with each other to protect the well-being of the body. This medicine can balance the functions of the heart and blood, the lungs and qi, the spleen and the liver, and the kidneys and the essence, so that the organs and organs cooperate seamlessly, such as orchestras singing in unison, playing a harmonious song together. Third, it may have the power of helping the right and removing evil. If the human body has sufficient righteous qi, the evil cannot be dried; if the righteous qi is weak, the evil qi is easy to invade. This medicine can help the human body's righteous qi, enhance the power to resist external evil spirits, and at the same time dispel the evil qi that has entered, just like building an embankment to prevent floods, and also dredging and removing the disease. Fourth, it also adjusts the emotion. The seven emotions of a person are sick. The medicine can relieve mental tension, make people feel peaceful, and their emotions are peaceful. It is like a breeze blowing on the face, and the worries are eliminated. In short, the pharmacological effects of this medicine are complex and delicate, and it is beneficial to human health. It is actually a good medicine that can solve the suffering of many diseases. However, the way of medication requires careful follow the doctor's advice and must not be used indiscriminately to avoid other changes.
What are the clinical applications of (±)-α-( 2- (diisopropylamino) ethyl) -α-phenyl-2-pyridyl acetamide phosphate (1:1)?
The temporary application of (±)-α-( 2- (diisopropylcarbamoyl) ethyl) -α-phenyl-2 to its acetylsalicylic anhydride (1:1) is commonly used in the fields of pharmaceutical research and development.
In the pharmaceutical preparation process, this compound combination may involve specific reaction steps. Or used in the synthesis of new drug molecules, with its special structure to endow drugs with specific activities and properties. For example, in the development of anti-platelet drugs, this temporary application form may help optimize the ability of drugs to bind to platelet receptors and improve antithrombotic efficacy.
From the perspective of pharmacological mechanism, its temporary application may affect the drug metabolism process. ( ±) -alpha - (2- (diisopropylcarbamoyl) ethyl) -alpha-phenyl moiety, or changes the absorption, distribution, metabolism and excretion characteristics of the drug in vivo. The 2-to-its acetylsalicylic anhydride (1:1) moiety may be directly related to the pharmacological effects of the drug, such as participating in key links such as inhibiting cyclooxygenase activity in platelets.
In the preclinical research stage, this temporary application form will be evaluated by many experiments. Including in vitro cell experiments to observe the impact on cell physiological functions, such as the inhibition effect on platelet aggregation; animal experiments will also be carried out to evaluate its safety and preliminary efficacy, such as observing the anti-thrombotic ability and adverse reactions in animal models.
What are the side effects of (±)-α-( 2- (diisopropylamino) ethyl) -α-phenyl-2-pyridyl acetamide phosphate (1:1)?
(±) -α -( 2 - (diisobutylamino) ethyl) -α-phenyl-2 - to its isobutylamide caseic anhydride (1:1), its side effects are various. This compound may be involved in the field of medicinal chemistry.
Substances that cover these chemical structures may affect human physiology in pharmacological action. First, there may be a risk of neurotoxicity. Its structure contains special alkyl and phenyl groups, which may interfere with the transmission of neurotransmitters and the metabolism of nerve cells, damage the nervous system, cause dizziness, fatigue, cognitive impairment, etc.
Second, or disturb the metabolic balance in the body. Its structural characteristics can increase the burden on metabolic organs such as liver and kidney, affect the activity of liver enzyme system, block metabolic pathway, or make toxins and wastes in the body difficult to excrete, tiring or abnormal liver and kidney function.
Third, or with abnormal immune regulation. Or cause immune system disorders, make the body's immune response excessive or insufficient, not only easy to cause allergies and other overreactions, but also reduce the body's disease resistance and increase the risk of disease.
Fourth, it may also affect the cardiovascular system. Or change blood vessel tension, change the electrophysiological characteristics of the heart, cause blood pressure fluctuations, arrhythmias and other diseases.
The degree and manifestation of these side effects vary from individual to individual, and are influenced by factors such as genetics, health status, and medication history. And the experimental environment and research methods are different, and the conclusions may vary. Therefore, a detailed study of such compounds to clarify their side effects is the key to medical research and development and clinical application, which can ensure the safety and effectiveness of medication.
What is the preparation method of (±)-α-( 2- (diisopropylamino) ethyl) -α-phenyl-2-pyridine acetamide phosphate (1:1)?
To prepare (±) -α -( 2 - (diisobutylamino) ethyl) -α-phenyl-2 -pyridine acetamide (1:1), the preparation method is as follows:
Take an appropriate amount of pyridine first, place it in a clean reactor, and cool it at low temperature to a suitable temperature, about -5 ° C to 0 ° C. In this low temperature environment, slowly add dropwise a solution containing a specific reagent. The reagent needs to be accurately proportioned in advance, which contains the key ingredients related to the reaction. For halogenated hydrocarbon derivatives that can react with pyridine in a specific way, the dropwise addition process must be uniform and slow to avoid overreaction.
After the dropwise addition is completed, maintain this low temperature state and continue to stir for more than two hours, so that the pyridine can fully react with the halogenated hydrocarbon derivative to form a preliminary intermediate product. This intermediate product has a complex structure and requires fine operation to ensure its purity.
Then, the temperature of the reaction system is slowly raised to room temperature, and then a reactant containing (2- (diisobutylamino) ethyl) -α-phenyl is added. This reactant needs to be strictly purified, and the impurity content must be extremely low. After adding, it is moderately warmed to about 50 ° C to 60 ° C, and the reaction is maintained at this temperature. During the reaction, it is continuously stirred to make the components fully contact the reaction. < Br >
After several hours of reaction, when the reaction is basically completed, the reaction product is post-processed. First, the extraction is carried out with a suitable organic solvent, which needs to have good solubility to the target product and is easy to separate from other impurities in the reaction system. After several extractions, the organic phases are combined, and then the residual moisture in the organic phase is removed with a desiccant such as anhydrous sodium sulfate.
Subsequently, the organic solvent is removed by vacuum distillation to obtain a crude product. The crude product still contains some impurities and needs to be further purified by column chromatography. A suitable silica gel is selected as the stationary phase, and a specific proportion of mixed organic solvent is used as the mobile phase. The crude product is loaded on the chromatographic column, eluted and separated, and the fractions containing the target product are collected.
Finally, the collected fractions are concentrated and crystallized. The finished product of (±) -α -( 2 - (diisobutylamino) ethyl) -α-phenyl-2-pyridyl acetamide (1:1) can be obtained. After testing the purity, it is the desired product. The whole preparation process requires strict control of the reaction conditions and operation details of each step to ensure the quality and yield of the product.