(+)-(3'S,4S)-1-Benzyl-3-Pyrrolidinyl Methyl 1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-3,5-Pyridinedicarboxylate

（+） - （ 3 ′ S, 4S) - 1 - benzyl - 3 - pyrrolidinyl methyl - 1,4 - dihydro - 2,6 - dimethyl - 4 - (3 - nitrophenyl) - 3,5 - pyridinedicarboxylate This compound has important uses. It is often used in the field of medicinal chemistry and plays a significant role in the process of drug development.
The way of drug creation, this compound may be used as a key intermediate. Due to its unique chemical structure, it has specific reactivity and spatial configuration, and can undergo delicate chemical reactions with many reagents. After ingenious transformation steps, more complex and biologically active molecular structures can be constructed. Therefore, when synthesizing new drug molecules, it is often relied on as the cornerstone to achieve the expected pharmacological efficacy.
Furthermore, in the field of organic synthetic chemistry, it is also a commonly used synthetic building block. With its own structural characteristics, it can participate in various types of organic reactions, such as esterification, cyclization, and substitution. Chemists can follow specific synthesis strategies and flexibly use this compound to achieve efficient synthesis of target products, contributing to the development of organic synthetic chemistry. Its wide application in the field of organic synthesis has promoted the exploration and creation of new compounds, injecting vitality into the progress of organic chemistry.

(+) - (3'S, 4S) -1-benzyl-3-pyrrolidenyl methyl 1,4-dihydro-2,6-dimethyl-4- (3-nitrophenyl) -3,5-pyridinedicarboxylate is an organic compound. In terms of physical properties, it is usually a solid, but it is difficult to obtain an exact value due to the precise melting point and boiling point, which often vary according to the synthesis method and purity.
Chemically, the structure of pyridinedicarboxylate in this compound gives it a certain hydrolytic activity. Under the catalysis of acid or base, the ester group can be hydrolyzed into the corresponding carboxylic acid or carboxylate. The 3-nitrophenyl moiety, the nitro group is a strong electron-absorbing group, reduces the electron cloud density of the benzene ring, decreases the activity of the electrophilic substitution of the benzene ring, but can enhance its tendency to undergo nucleophilic substitution. Furthermore, the nitrogen atom in the pyrrolidine group has a solitary pair of electrons, which can exhibit certain alkalinity and can form salts with acids, and this site may participate in nucleophilic reactions. Benzyl in the 1-benzyl moiety, under certain conditions, the benzyl C-H bond can be activated, and various reactions can occur. In addition, the chiral center (3'S, 4S) endows the compound with optical activity, which may have potential application value in the field of asymmetric synthesis and chiral drug development.

To prepare (+) - (3 ′ S, 4S) -1 -benzyl-3-pyrrolidylmethyl 1,4 -dihydro-2,6 -dimethyl-4 - (3 -nitrophenyl) -3,5 -pyridinedicarboxylate, the synthesis method needs to follow delicate steps.
At the beginning, suitable raw materials can be selected, such as pyridine derivatives and pyrrolidine derivatives with specific structures. First, the pyridine derivative is used as the base, and the substituent is introduced at a specific position. Here, the methyl group is introduced at the 2nd and 6th positions of the pyridine ring, which can be achieved by a specific alkylation reaction. Commonly used alkylating reagents, such as iodomethane, can be successfully introduced into methyl groups in the presence of suitable bases, such as potassium carbonate, and in suitable solvents, such as acetonitrile.
Then, 3-nitrophenyl is introduced at the 4th position of the pyridine ring. This step can be achieved by a coupling reaction, such as the use of suitable palladium catalysts, such as tetra (triphenylphosphine) palladium, etc., under basic conditions, the pyridine derivative is coupled to a halogenated aromatic hydrocarbon containing 3-nitrophenyl. In this way, 3-nitrophenyl is successfully connected to the pyridine ring.
As for the pyrrolidine derivative, the methyl group is introduced before the 3rd position, and the Grignard reagent or the alkyl lithium reagent can be used to react with the suitable pyrrolidone derivative. After the methyl group is introduced, the benzyl group is introduced at the 1st position, and the benzylation can be completed in a basic environment by means of nucleophilic substitution reaction with benzyl halide as a reagent.
Finally, the modified pyridine derivative is esterified with the pyrrolidine derivative. The target product (+) - (3 ′ S, 4S) -1 -benzyl-3 -pyrrolidomethyl 1,4 -dihydro-2,6 -dimethyl-4 - (3 -nitrophenyl) -3,5 -pyridinedicarboxylate can be obtained by selecting an appropriate condensing agent, such as dicyclohexyl carbodiimide (DCC), etc. The reaction process requires fine control of the reaction temperature, time and the amount of each reagent to ensure the smooth progress of the reaction and improve the purity and yield of the product.

(+) - (3'S, 4S) -1-benzyl-3-pyrrolidenyl methyl 1,4-dihydro-2,6-dimethyl-4- (3-nitrophenyl) -3,5-pyridinedicarboxylate related Quality Standards are not directly related to this substance in Tiangong Kaiwu, but can be compared to the idea of controlling the quality of materials.
The quality of a substance is the first color. When viewed in its shape, this compound should be in a specific crystalline state or powdery state, with pure color and no variegated foreign matter. If it is cloudy, discolored or agglomerated, it is a sign of poor quality.
Odor is also key. Pure this material, the smell should be calm, no pungent, rancid and other odors. For example, in "Tiangong Kaiwu", various materials are distinguished by smell, and the odor often shows impurities or deterioration.
In terms of purity, it should be extremely high. Impurities such as unreacted raw materials, by-products, etc., should be minimal. For example, in "Tiangong Kaiwu", the pursuit of purification of various products, high purity is the quality assurance. It can be measured by precise methods, such as chromatography, and its purity cannot be determined. If it does not reach the standard of high purity, it must not be a good product.
Stability should not be ignored. Under normal temperature and specific environments, it should be able to maintain its chemical structure and properties for a long time. For example, the materials in "Tiangong Kaiwu" need to be properly stored on time and in place, and this compound should also be protected from light, moisture, and high temperature to ensure its stability.
In addition, solubility is also considered. In a specific solvent, it should have the expected solubility, which is related to its performance in subsequent applications such as pharmaceutical and chemical synthesis. Just like the adaptability of materials in "Tiangong Kaiwu" in different processes, the solubility does not match, or the process is blocked, and the product does not meet expectations.

I don't know what the market price of (+) - (3'S, 4S) -1-benzyl-3-pyrrolidenyl methyl 1,4-dihydro-2,6-dimethyl-4- (3-nitrophenyl) -3,5-pyridinedicarboxylate is. The price in the city often varies according to the situation of time, place, quality and supply and demand. The price of this product may vary in different pharmaceutical markets and chemical raw material fields. And its preparation cost and market demand can all affect its price. If you want to know its exact price, you should go to the chemical raw material market and pharmacy, consult the shopkeeper and merchants; or interview the trade name specializing in these chemicals and ask for its price; you can also check the price in the chemical raw material trading shop. However, because I have not been involved in real-time business conditions, it is difficult to express the price. You need to explore for yourself before you can obtain the exact number.