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What is the chemical structure of [1,3] Oxazolo [4,5-b] pyridine-2-thiol
Alas! The chemical structure of [1,3] -azolo [4,5-b] pyridine-2-mercaptan you are inquiring about is quite exquisite. This is a class of compounds containing nitrogen, oxygen and sulfur heterocycles. Its core structure is a pyridine ring fused to an oxazole ring. The oxazole ring consists of one oxygen atom, one nitrogen atom and three carbon atoms to form a five-membered ring, and the pyridine ring consists of five carbon atoms and one nitrogen atom to form a six-membered ring. The two fused in a specific way to form a unique skeleton.
At the 2-position of the [4,5-b] pyridine skeleton, a thiol group (-SH) is connected. This thiol group endows the compound with unique chemical activity, because it has lone pair electrons on the sulfur atom, which is easy to participate in various chemical reactions, such as nucleophilic substitution, redox, etc.
The structure of this [1,3] -azolo [4,5-b] pyridine-2-thiol makes it have potential applications in many fields such as medicinal chemistry and materials science. In medicinal chemistry, its unique structure may interact with bioactive molecules to exhibit pharmacological activities such as antibacterial, anti-inflammatory, and anti-tumor; in materials science, its structure may endow materials with special optical and electrical properties. In this way, the chemical structure of [1,3] -azolo [4,5-b] pyridine-2-thiol contains endless mysteries and possibilities.
What are the physical properties of [1,3] Oxazolo [4,5-b] pyridine-2-thiol
[1,3] [4,5-b] pyridine-2-mercaptan This substance has various physical properties. Under normal conditions, it is in a solid state, and it may appear crystalline. The color is often almost white, but it may also have a slightly yellow appearance due to the presence of impurities.
When it comes to the melting point, this substance is about a certain temperature range, because the exact value varies depending on the degree of purification and measurement conditions. Generally speaking, its melting point is relatively high. Due to the close interaction between atoms in its molecular structure, more energy is required to break its lattice, causing the lattice to disintegrate and melt into a liquid state. < Br >
In terms of solubility, it shows a certain difference in solubility in common organic solvents. In polar organic solvents, such as methanol and ethanol, it can have moderate solubility, and some groups in the genine molecule can form hydrogen bonds or other intermolecular forces with polar solvent molecules to help them disperse in solvents. However, in non-polar organic solvents, such as n-hexane and toluene, the solubility is very small, because the molecular polarity and non-polar solvents do not match, and the force between the two is weak.
Furthermore, its density is also a specific value, which reflects the degree of molecular packing compactness and is affected by molecular structure and crystal form. And this material has a certain stability, under normal temperature, pressure and general environmental conditions, it can maintain its own structure, and it is not easy to spontaneously undergo chemical reactions. When encountering specific chemical reagents or in special conditions, such as high temperature, strong acid and alkali environment, its structure may change, which is also related to the activity of functional groups in the molecular structure.
What is the main use of [1,3] Oxazolo [4,5-b] pyridine-2-thiol?
[1,3] azolo [4,5-b] pyridine-2-thiol is one of the organic compounds. It has a wide range of uses and is often used as an intermediate in drug synthesis in the field of medicinal chemistry. Due to its special molecular structure, it can participate in a variety of chemical reactions and assist pharmaceutical chemists in creating new drug molecules with specific biological activities.
In the field of materials science, this compound may be useful for the improvement of the properties of certain materials. For example, it may be used to combine with specific materials to impart properties such as oxidation resistance and corrosion resistance to materials, and improve the stability and durability of materials.
In the research and development of pesticides, [1,3] oxazolo [4,5-b] pyridine-2-thiol also has potential application value. Or its structure can be modified to create a new type of pesticide that is highly toxic to specific pests but environmentally friendly, helping to control agricultural pests and reduce adverse effects on the ecological environment.
In addition, in the basic research of organic synthetic chemistry, this compound is often used as a model molecule to explore the mechanisms and laws of various chemical reactions. By studying the reactions involved, chemists can expand their knowledge of organic synthesis methodologies and provide new ideas and strategies for the synthesis of more complex organic molecules.
What are the synthesis methods of [1,3] Oxazolo [4,5-b] pyridine-2-thiol
There are several methods for the preparation of [1,3] -azolo [4,5-b] pyridine-2-mercaptan. The technique of organic synthesis is delicate and complicated, and the way is not the same.
One method is to first take a suitable pyridine compound as the starting material, and introduce a sulfur-containing functional group under specific reaction conditions. This requires precise temperature control and selection of suitable reagents. For example, in an inert solvent, a specific base is used as the catalyst to slowly react the pyridine derivative with the sulfur-containing reagent for several hours to rearrange and combine the chemical bonds, and gradually form the prototype of the target molecule. After the reaction is completed, it is purified by extraction, column chromatography, etc., and a purer product is obtained. < Br >
Another method can be started from [1,3] -azole compounds. Such compounds are modified to expose their active checking points and then coupled to reagents containing pyridine and sulfur atoms. In this process, the polarity of the solvent and the pH of the reaction are all key. Or in a mild heating state, the reactants are fully contacted and reacted, following the mechanism of organic reactions to construct the structure of the target molecule. After the reaction is completed, purification methods such as recrystallization are applied to obtain pure [1,3] -azolo [4,5 - b] pyridine-2 - thiol.
Furthermore, metal catalysis can be used. Select specific metal catalysts, such as palladium, copper, etc., with the assistance of organic ligands, to catalyze the coupling between the reactants. This can improve the selectivity and efficiency of the reaction. In a specific reaction system, each reactant is gradually constructed according to the way of metal catalysis, and the skeleton of the target compound is finally formed into [1,3] -azolo [4,5-b] pyridine-2-thiol. Then it is separated and refined to obtain a high-purity product to meet the needs of experiments or industry.
[1,3] Oxazolo [4,5-b] pyridine-2-thiol What to pay attention to when storing and transporting
[1,3] oxazolo [4,5-b] pyridine-2-thiol This substance should be stored and transported with caution. Its nature is sensitive, or it should be in response to temperature, humidity and light. Therefore, when storing, it is advisable to choose a cool and dry, dark and common place to avoid direct sunlight and moisture. The temperature should be normal, and it should not be too high or too low to prevent its quality from changing.
When shipping, it should also be protected from shock and damage. Pack must be solid to prevent leakage. And separate it from other things, avoid it from contact with strong oxygen agents, strong acids, strong alkalis, etc., for fear of dramatic reaction and danger.
Also, [1,3] oxazolo [4,5-b] pyridine-2-thiol is toxic, and the operator must wear protective equipment, such as gloves, eyepieces, masks, etc., to protect himself. After finishing, you must clean your hands and face to avoid it remaining in the body.
All these things are for those who should pay attention to and obey [1,3] oxazolo [4,5-b] pyridine-2-thiol, so as to protect the safety of things and the health of people.