Pyrazinecarbonyl Chloride
pyridine pyrrole pyrazine piperidine piperazine

Pyrazinecarbonyl chloride

    Specifications

    HS Code

    908128

    Name Pyrazinecarbonyl chloride
    Chemical Formula C5H3ClN2O
    Molar Mass 142.54 g/mol
    Appearance Solid (usually white or off - white)
    Odor Pungent
    Solubility In Water Reacts with water
    Solubility In Organic Solvents Soluble in many organic solvents like dichloromethane
    Melting Point 63 - 65 °C
    Boiling Point 222 - 224 °C
    Reactivity Highly reactive towards nucleophiles

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    Frequently Asked Questions

    As a leading Pyrazinecarbonyl chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the physical properties of Pyrazinecarbonyl chloride?
    Pyrazine formyl chloride is an important compound in organic chemistry. Its physical properties are particularly critical and are detailed as follows.
    Looking at its properties, under normal temperature and pressure, pyrazine formyl chloride is often colorless to light yellow liquid, with pure color and no noise. Its appearance is clear and there is no cloudy state, just like clear water, but it has its own unique properties.
    As for its boiling point, it is between 198 and 200 degrees Celsius. This boiling point temperature indicates that a considerable amount of heat is required to transform it from liquid to gas. When heated near this temperature range, the molecules of pyrazine formyl chloride are energized to intensify their movement, breaking free from the attractive forces between molecules, and thus boiling into a gas phase.
    In terms of melting point, its melting point is about -22 ° C. This low temperature melting point means that pyrazine formyl chloride can still maintain a liquid state in a normal low temperature environment. Only when the temperature drops sharply to about -22 ° C and below, the molecular movement slows down significantly, close to each other and arranged in an orderly manner, and begins to condense into a solid state.
    The density of pyrazine formyl chloride is about 1.33 g/cm ³. This density value is higher than that of water. If it is placed in one place with water, it will sink underwater, because the mass contained in the unit volume is more considerable.
    Furthermore, its solubility is also one of the important physical properties. Pyrazine formyl chloride is soluble in many organic solvents, such as dichloromethane, chloroform, ether, etc. In these organic solvents, pyrazine formyl chloride can well miscible with solvent molecules to form a uniform solution system. However, its solubility in water is not good, and it is easy to react in contact with water, hydrolyzing to form pyrazine formic acid and hydrogen chloride. This property also determines its behavior in different environments.
    In addition, pyrazine formyl chloride has a pungent odor and a pungent smell. This odor is also one of its physical properties, which impresses the human senses. When operating and using, special attention should be paid to it because of its irritation or damage to the human respiratory tract, eyes, etc.
    What are the chemical properties of Pyrazinecarbonyl chloride
    Pyrazine formyl chloride is a crucial chemical in organic synthesis. It has active chemical properties and exhibits unique properties in many chemical reactions.
    Looking at its nucleophilic substitution reaction, the carbonyl carbon of pyrazine formyl chloride is positively charged and vulnerable to attack by nucleophiles. In case of alcohols, pyrazine formate can be formed. This reaction is like a carefully choreographed "chemical dance". The oxygen atom of the alcohol rushes towards the carbonyl carbon in a nucleophilic manner, and the chloride ion flutters away. A new ester bond is born. When it encounters an amine, an amide is formed. The nitrogen atom of the amine attacks the carbonyl carbon with its lone pair electrons, such as the brave knight, and the chloride ions retreat from the stage, and the amide products are formed.
    Its hydrolysis reaction cannot be ignored. In the water environment, pyrazine formyl chloride is like a "water baptism", and water molecules disassemble its structure. Hydroxyl groups replace chlorine atoms, and pyrazine formyl acid is formed, and hydrogen chloride is released at the same time. In this process, the change of chemical structure is like a change in the microworld.
    In the field of organic synthesis, pyrazine formyl chloride is often used as a key intermediate. Due to its active chemical properties, it can provide a convenient way to construct complex organic molecules. Using it as a starting material and through a series of reactions, various compounds containing pyrazine structures can be prepared, which have potential application value in many fields such as drug development and materials science. Its lively nature is like the key to opening a new world of chemical synthesis, leading chemists to explore more unknown realms.
    Pyrazinecarbonyl chloride is used in what fields
    Pyrazine formyl chloride is useful in many fields such as chemical industry, medicine, materials, etc.
    In the chemical industry, it is often a key intermediate in organic synthesis. It can react with various compounds containing active hydrogen, such as alcohols and amines, through a specific reaction path. When reacted with alcohols, pyrazine formate compounds can be formed. Such products are useful in the preparation of fragrances, plasticizers, etc., which can give the product a unique aroma or improve its physical properties. When reacted with amines, pyrazine formamides are formed, which are indispensable in the synthesis of some functional auxiliaries.
    In the field of medicine, pyrazine formyl chloride is of great significance. The construction of many drug molecules depends on its participation. Taking the development of anti-tuberculosis drugs as an example, pyrazine formamide derivatives with specific structures can be prepared by using pyrazine formyl chloride as the starting material through a series of reactions, which have inhibitory or killing effects on Mycobacterium tuberculosis. In addition, in the development of anti-tumor drugs, compounds containing pyrazine formyl chloride-derived structures have become one of the research hotspots because they can interact with specific targets in tumor cells and exhibit potential anti-cancer activities.
    In the field of materials, pyrazine formyl chloride also plays an important role. It can be used to prepare high-performance polymer materials. Polymers with unique properties are formed by polymerizing with monomers containing specific functional groups. For example, by polymerizing with aromatic monomers containing hydroxyl or amino groups, the resulting polymer may have excellent thermal stability and mechanical properties, and can be used as a structural material or insulating material in high-end fields such as aerospace, electronics, and electrical appliances.
    All in all, pyrazine formyl chloride has high reactivity and can derive a variety of structures. It is widely used in many fields such as chemical industry, medicine, and materials, and is of great significance for promoting technological progress and innovation in various fields.
    What is the synthesis method of Pyrazinecarbonyl chloride?
    To prepare pyrazinoformyl chloride, start with pyrazinoformic acid. First take an appropriate amount of pyrazinoformic acid and put it in a clean reactor. Slowly add thionyl chloride into the kettle, and the molar ratio of the two should be carefully prepared. Usually, the molar ratio of pyrazinoformic acid to thionyl chloride is about 1:1.2 - 1:1.5. Sulfoxide chloride is both a chlorination reagent and a solvent.
    After adding, seal the reactor and slowly heat it up to 70-80 ° C. At this temperature, it takes about 3-5 hours to fully react. During the reaction, a considerable amount of hydrogen chloride gas escapes, which is a sign of the reaction.
    After the reaction is completed, first cool down to room temperature. Then, the excess sulfoxide chloride is removed by distillation under reduced pressure. During distillation, the pressure and temperature are controlled, the pressure is about 0.09-0.1MPa, and the temperature is about 40-50 ℃.
    After removing the purified sulfoxide chloride, the remaining product in the kettle is crude pyrazine formyl chloride. Then purified by distillation, the fraction in a specific boiling point range is collected, and pure pyrazine formyl chloride can be obtained. During distillation, the pressure is about 0.095-0.1MPa, and the boiling point is about 140-145 ℃.
    This preparation method is still convenient to operate, and the yield and purity of the product can be observed, which can be a good strategy for the preparation of pyrazine formyl chloride.
    What are the precautions when using Pyrazinecarbonyl chloride
    There are many things to pay attention to when using pyrazine formyl chloride. This is a chemical substance that is dangerous and must be used with caution.
    First, protective equipment is indispensable. Users should wear protective clothing, a protective cap, eye protection glasses, and protective gloves to prevent it from touching the skin and eyes. Because it may be irritating to the skin and eyes, it can even cause burns. If you contact it inadvertently, rinse with plenty of water immediately and seek medical attention immediately.
    Second, the operating environment is extremely critical. It must be operated in a well-ventilated place, preferably in a fume hood, to avoid inhaling its volatile gases. The gas may be irritating to the respiratory tract. Inhalation in large quantities can cause respiratory discomfort, such as cough, asthma and other symptoms.
    Third, storage should also be cautious. Pyrazine formyl chloride should be stored in a cool, dry and well-ventilated place, away from fire and heat sources, and protected from direct sunlight. At the same time, it should be stored separately from oxidants, alkalis, etc., and should not be mixed to avoid chemical reactions and lead to danger.
    Fourth, during use, it is necessary to strictly follow the operating procedures. Take an appropriate amount to avoid waste and unnecessary danger. After operation, be sure to thoroughly clean the utensils, properly dispose of the remaining items, and do not discard them at will to prevent pollution of the environment. In short, when using pyrazine formyl chloride, every detail should not be taken lightly. Only by strictly adhering to relevant regulations can we ensure safe operation and avoid accidents.