PYRAZINEAMINE

Pyrazinamide is a good medicine for anti-tuberculosis. Its main use is to treat tuberculosis. In the treatment of tuberculosis, it is often combined with other anti-tuberculosis drugs to increase the efficacy and reduce the drug resistance of tuberculosis bacteria.
Today's medicine knows that tuberculosis bacteria are cunning, and one drug is used alone, which is prone to drug resistance. Therefore, when treating tuberculosis, several drugs are used in combination, and pyrazinamide is often used as a drug. After it enters the body, it is metabolized and transformed, and it can exert its bactericidal ability in an acidic environment. The focus of tuberculosis often has an acidic microenvironment. Pyrazinamide can break the cell wall and cell membrane of tuberculosis bacteria in this environment, disturb its metabolism, and eventually cause tuberculosis bacteria to die, achieving the purpose of treating the disease.
Clinical treatment, depending on the patient's condition and the severity of the disease, the agent of pyrazinamide is determined. It is often used with isoniazid, rifampicin, ethambutol, etc. as a first-line anti-tuberculosis prescription. Adhering to the rules of medication can make many pulmonary tuberculosis patients recover and be as healthy as ever. And in the first treatment and rehabilitation of pulmonary tuberculosis, pyrazinamide has important uses, making great contributions to controlling tuberculosis and protecting public health.

Pickazinamide is a commonly used medicine for medical treatment of tuberculosis. However, it also has various side effects, which cannot be ignored.
First, it has damage to the liver. The liver is the body's blood storage and detoxification. Pickazinamide enters the body, or disturbs the excretion of the liver, resulting in abnormal liver function. In mild cases, transaminase may be increased, and patients often feel hidden pain in the ribs, fatigue, and loss of appetite; in severe cases, it may cause jaundice, the body and eyes are yellow like orange, and the urine is yellow and red like strong tea.
Second, joint diseases are also common. Pickazinamide can cause uric acid excretion to be blocked, and uric acid accumulates in the body and flows into the joints, resulting in joint pain. Initially or only involves the small joints such as fingers and toes, pain is mostly dull pain, tingling, and intensifies when moving; if the disease persists, the large joints may also be invaded, and in severe cases, joint swelling and deformity may be caused, affecting limb movement.
Third, gastrointestinal reactions are not uncommon. When medicine enters the gastrointestinal tract, it is easy to disturb its health and descent. Common nausea and vomiting, stomach qi goes up, and vomiting immediately after eating; there are also abdominal pain, diarrhea, abnormal spleen and stomach transportation, and water and grain do not melt down.
Fourth, a few patients may have allergic changes. Drug poison invades and guards, skin rashes can be seen, itching is intolerable, and even hot topics can occur, heat disturbs the gods, or causes delirium and other symptoms.
When a doctor uses this drug, he must carefully observe the patient's condition, weigh the pros and cons, and frequently check liver function, uric acid, etc. during the medication, so as to get early detection of abnormalities and timely treatment to reduce their harm and make the best of it.

Pyrazinamide is a good medicine for tuberculosis. Its usage is exquisite, and it should be used with caution according to the advice of a doctor.
All use of this medicine is usually taken orally. The dosage is determined, often depending on the patient's weight, body shape, and the priority of the disease. For adults, take 15 to 30 milligrams per kilogram of body weight per day, divided into one to three doses. Children, the medication should be especially careful, and the dosage should be determined according to their weak body, so as to ensure safety.
When taking medication, you should also pay attention to the time. Or take it with meals, so as to reduce gastrointestinal discomfort. And take this medicine, you must persevere, use it according to the course of treatment, and do not give up halfway. The length of the course of treatment depends on the condition of tuberculosis, which can be as short as several months, long or menstrual years, to ensure that the disease is completely eliminated and the righteous qi is restored.
When taking medication, its adverse reactions should also be observed. If you see signs of liver damage, such as jaundice, hypochondria, fatigue, or gastrointestinal diseases, such as nausea, vomiting, and loss of appetite, you must immediately report to the doctor to determine the advance and retreat strategy.
In short, the use of pyrazinamide is related to the health of the patient. The doctor should carefully review the condition and fine-tune the dosage. The patient also needs to follow the instructions. In this way, the effect of the medicine can be obtained and the suffering of tuberculosis can be eliminated.

Pyrazinamide is a good medicine used by doctors to fight tuberculosis. Its storage method is related to the preservation and waste of the efficacy of the drug, and must not be ignored.
In the storage place, it is appropriate to choose a dry and cool place. Pyrazinamide likes dryness. If it is in a humid place, water vapor is easy to invade and cause the drug quality to mutate. And it needs to be protected from direct sunlight, which is hot in the sun, which can damage the active ingredients of the drug, and the efficacy will be reduced.
Furthermore, when storing, it must be tightly sealed. If the packaging is not strict, air is mixed in, or it is stained with peculiar smell, it can damage the drug quality.
Also, temperature is also the key. At room temperature, between about 15 and 30 degrees Celsius, it can keep its quality stable. If the temperature is too high, the medicine will deteriorate easily; if the temperature is too low, or the properties of the medicine will change, affecting its effectiveness.
Storage devices are also exquisite. It is better to use a glass or plastic sealed container, which is pure in material and does not chemically react with the medicine, which can protect the quality of the medicine for a long time. And it must be placed out of the reach of children to prevent the risk of accidental ingestion. In this way, the effect of pyrazinamide can be stored for a long time to relieve the disease of patients.

Pyrazinamide is a good drug for anti-tuberculosis. Its interaction with various drugs is related to the therapeutic effect and safety, and cannot be ignored.
The combination of pyrazinamide and isoniazid, the synergistic effect of the two, can cause damage to the cell wall and cell membrane of tuberculosis bacteria, prevent their metabolism and reproduction, but also increase the risk of liver damage. Because the two metabolize in the liver, combined use causes hepatic load to increase, prone to increased transaminase, jaundice and other diseases.
Combined with rifampicin, it is also a commonly used combination for anti-tuberculosis. Rifampicin breaks the RNA synthesis of tuberculosis bacteria, and pyrazinamide helps it enter the bacteria, and the two work together to improve the bactericidal power. However, with this compatibility, gastrointestinal discomfort symptoms are common, such as nausea, vomiting, anorexia, etc., and hepatotoxicity is superimposed. Liver function needs to be checked frequently during medication.
Streptomycin is used in combination with pyrazinamide, which acts on the protein synthesis of tuberculosis bacteria and interferes with its metabolism. It is beneficial for the treatment of severe tuberculosis. However, streptomycin has otorenal toxicity, and pyrazinamide also damages the liver and joints. When used in combination, it is necessary to pay attention to hearing, renal function and joint symptoms, and beware of toxic side effects.
In addition, the combination of pyrazinamide and ethambutol can expand the antibacterial spectrum, but ethambutol has the risk of optic neuritis, and pyrazinamide affects uric acid metabolism. When combined, vision and uric acid levels should be checked to prevent vision loss and gout. When using this drug, doctors must carefully review the patient's condition, weigh the advantages and disadvantages, and carefully match it to achieve the best treatment and prevent all kinds of adverse reactions.