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What is the function of Amiloride?
Amiloride is also a diuretic agent. Its function is good at preserving potassium and promoting urination, and it is quite effective in preventing the accumulation of water treatment solution.
It covers the metabolism of human water and is related to many viscera. The kidney dominates water, and the division opens and closes. If gasification loses the division, the water will stop inside. Amiloride acts on the distal convoluted tubules and collecting ducts of the kidney, which can block the sodium channel in the lumen membrane and reduce the sodium reabsorption. Sodium is the leader of water. If there is less sodium reabsorption, the water will be excreted, which is also the reason for its diuretic effect.
And the specificity of this drug lies in the power of preserving potassium. Common diuretic agents often cause potassium to come out with the urine, resulting in a decrease in blood potassium. However, amiloride is not the case. When it blocks sodium reabsorption, it can reduce the secretion and excretion of potassium, so that blood potassium can be maintained at a constant level. In this way, it is very appropriate for those who are at risk of low potassium in edema, or who need to take diuretics for a long time to prevent low potassium.
In clinical cases, such as cardiogenic edema, renal edema, and cirrhotic ascites. If the urine is unfavorable due to internal hydrosis and needs to be prevented from potassium loss, amiloride is often selected by doctors. However, when taking medication, it is also necessary to review the patient's body shape and weigh the pros and cons to achieve the best effect and avoid its possible harm.
What are the side effects of Amiloride?
Amiloride is a diuretic drug. Although it has the ability to treat edema and control blood pressure, it also has various adverse reactions.
The first person to bear the brunt is hyperkalemia. This drug can block the excretion of potassium ions in the remote convoluted tubules and collecting ducts, causing blood potassium to rise. Light or only see fatigue, burnout, severe can cause arrhythmia, even life-threatening. Therefore, when taking medication, it is necessary to measure blood potassium frequently to prevent accidents.
Times, there are gastrointestinal discomfort. Such as nausea, vomiting, diarrhea, abdominal pain, etc., are quite common. This may be because the drug stimulates the gastrointestinal mucosa and disrupts its normal movement and transformation. In mild cases, it can be tolerated, and in severe cases, treatment and medication are required to relieve the suffering.
Furthermore, long-term or excessive use can cause hyponatremia. Sodium, an indispensable electrolyte in the human body, is related to body fluid balance, nerve conduction, etc. When low sodium, people may experience dizziness, fatigue, drowsiness, and even brain edema, which is very dangerous.
A few people may develop allergies after taking the drug. Rashes, itching, etc., although uncommon, should not be taken lightly.
In addition, there are adverse reactions such as dry mouth, dizziness, and sexual dysfunction. Although relatively rare, it should be paid attention to. If the user has any discomfort, it is advisable to inform the doctor immediately to determine whether it is necessary to adjust the medication method to protect his health.
How is Amiloride used?
For amiloride, it is also a diuretic medicine. The method of its use must follow the doctor's advice.
Ordinary people use it, the oral dose is about 5-10 mg, once a day, it should be taken in the morning on an empty stomach, or with meals. If it is necessary for the disease, the doctor may adjust the amount, but the daily amount rarely exceeds 20 mg.
Children use this drug, the amount depends on their weight, must be carefully considered by the doctor, and must not be determined.
When using the drug, it is necessary to closely observe its physical signs, such as the number of blood potassium. This medicine can cause an increase in blood potassium. If you see fatigue, heart palpitations, arrhythmia, fear of abnormal blood potassium, you should report it to the doctor as soon as possible. Also, if you take it with other medicines, you must be warned of changes in the combination of medicines. If you take it with potassium-preserving medicines, the risk of blood potassium rising will increase sharply; when used with potassium-excreting medicines, or the method of potassium metabolism. Therefore, before taking medicine, you must inform the doctor of all medicines you have taken, so that the doctor can understand its advantages and disadvantages.
Furthermore, pregnant women and nursing mothers should be especially cautious when using this medicine. If pregnant women are not life-threatening diseases, do not use it lightly; if nursing mothers use it or pass it on to their infants through milk, they should also carefully review the advantages and disadvantages and follow the doctor's orders.
What drugs does Amiloride interact with?
Amiloride is also a potassium-retaining diuretic. It can interact with many drugs in the body, which is related to the safety and efficacy of medication, and cannot be ignored.
When used in combination with potassium-retaining diuretics such as spironolactone, although both have the ability to retain potassium, the risk of elevated blood potassium increases sharply when used in combination. Although the mechanism of action of the two is slightly different, they both cause potassium ions to remain in the body. Therefore, when used in combination, it is necessary to closely monitor the blood potassium concentration to prevent the occurrence of hyperkalemia.
When used in combination with thiazide diuretics such as hydrochlorothiazide, it is synergistic. Thiazide diuretics excrete potassium, while amiloride retains potassium. The combination of the two can increase the diuretic power, balance the metabolism of potassium ions, and reduce the risk of electrolyte disorders. However, it should also pay attention to changes in blood sodium, blood uric acid and other indicators.
The combination of amiloride and digitalis drugs can affect the effect of digitalis due to changes in blood potassium. When blood potassium is reduced, the affinity between digitalis and receptors on the membrane of cardiomyocytes increases, which is prone to digitalis poisoning and arrhythmia; when blood potassium is increased, the effect of digitalis can be antagonized. Therefore, when combined, it is appropriate to monitor the blood potassium and digitalis blood drug concentrations.
Furthermore, when used in combination with non-steroidal anti-inflammatory drugs, non-steroidal anti-inflammatory drugs can inhibit prostaglandin synthesis and weaken the diuretic effect of amiloride. And both can cause kidney damage, and the risk of kidney damage is increased when used in combination.
In addition, the use of amiloride in combination with lithium agents can reduce renal excretion of lithium agents, increase blood lithium concentration, and increase the possibility of lithium poisoning.
All of these, when a doctor uses drugs, he must carefully review the patient's medication history, weigh the pros and cons, and observe the impact of drug interactions to ensure the safety and effectiveness of medication.
Which groups of people are not suitable for using Amiloride?
Amiloride is a kind of diuretic agent, but some people should not use it.
The first person to bear the brunt is the person who is allergic to Amiloride. Allergies can cause skin rash, redness and swelling, and can lead to shortness of breath and shock. Therefore, this kind of person should not use this drug.
People with renal failure are also not suitable. Kidney, the department of excretion, when kidney failure, drug metabolism and excretion are blocked, and Amiloride accumulates in the body, which is easy to cause hyperkalemia and other dangerous diseases. Excessive blood potassium can disturb the electrophysiology of the heart, cause arrhythmia, and even endanger life.
Patients with hyperkalemia are also contraindicated. Anshutong has the ability to retain potassium. If you have high blood potassium, using this drug again is like adding fuel to the fire, making the blood potassium higher and aggravating the condition.
Pregnant women and breastfeeding women use with caution. Medication during pregnancy is related to the safety of the fetus; use during breastfeeding, the drug may be transmitted to the infant through milk. The safety of this drug to the fetus and infant is unknown, so it is necessary to weigh the pros and cons and proceed with caution.
In addition, in patients with serious liver function impairment, the liver metabolism of drugs is impaired, the metabolism of Anshutong is hindered, or adverse reactions are caused, and it is not advisable to use it easily. When it comes to medication, it is crucial to one's life. Therefore, one must carefully review the patient's condition and follow the doctor's advice to ensure safety.
