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What is the chemical structure of 8- ((3R, 4S) -4-ethylpyrrolidin-3-yl) -3H-imidazo [1,2-a] pyrrolo [2,3-e] pyrazine?
This is the name of an organic compound. To clarify its chemical structure, it needs to be analyzed according to the rules of organic chemistry. In "8- ((3R, 4S) - 4 - ethylpyrrolidin - 3 - yl) - 3H - imidazo [1,2 - a] pyrrolo [2,3 - e] pyrazine", the main structure is "imidazo [1,2 - a] pyrrolo [2,3 - e] pyrazine", which is a three-ring fused system, which is formed by fusing the imidazole ring, pyrrole ring and pyrazine ring. "3H" indicates the presence of hydrogen atoms at a specific location. " 8- ((3R, 4S) - 4 - ethylpyrrolidin - 3 - yl) "is a substituent attached to the main structure at position 8." (3R, 4S) - 4 - ethylpyrrolidin - 3 - yl "is a chiral pyrrolidine group, ethyl is present at position 4, and positions 3 and 4 have R and S configurations, respectively.
Therefore, the structure of the compound is based on imidazolo-pyrrolidin as the main body, and position 8 is connected with a specific chiral 4-ethylpyrrolidin-3-yl substituent. The structure schematics are roughly as follows: first draw the imidazole-pyrrole-pyrazine tricyclic fused skeleton, and extract the bonding (3R, 4S) -4-ethylpyrrolidine-3-yl at position 8, and add ethyl at position 4 of this group pyrrole ring. At the same time, the spatial orientation of positions 3 and 4 is shown according to the R and S configuration rules.
What are the physical properties of 8- ((3R, 4S) -4-ethylpyrrolidin-3-yl) -3H-imidazo [1,2-a] pyrrolo [2,3-e] pyrazine?
(8- ((3R, 4S) -4-ethylpyrrolidine-3-yl) -3H-imidazolo [1,2-a] pyrrolido [2,3-e] pyrazine) The physical properties of this substance are quite critical and related to many uses.
Looking at its shape, at room temperature, or in a solid state, it is crystalline and has a regular geometric shape. The crystal surface is smooth and shines brightly, like a treasure made in heaven. Its color may be plain white, pure and impure, like snow, and like flawless jade, showing its pure state.
As for the melting point, after rigorous determination, it is about a certain temperature range. When heated up to this point, the energy of the lattice gradually increases, the molecules break free, the lattice disintegrates, and the solid state slowly turns into a liquid state. This process is the key node of the substance from solid to liquid, which is related to its thermal stability and subsequent processing conditions.
In terms of solubility, in specific organic solvents, it can show different degrees of solubility. In polar organic solvents, such as alcohols, there may be a certain solubility, and the molecules and solvent molecules interact with each other through hydrogen bonds to form a uniform solution. In non-polar solvents, such as alkanes, the solubility may be very low. Due to the difference in molecular polarity, the interaction force is weak and it is difficult to be compatible.
In addition, density is also one of its important physical properties. After accurate measurement, the mass per unit volume can be known. This value is of great significance in the process of separation and mixing of substances, and is related to their distribution and behavior in the system.
These physical properties are useful for guiding researchers in the fields of pharmaceutical research and development, material synthesis, etc., to help researchers grasp their characteristics and apply appropriate methods to achieve the desired effect.
What are the main uses of 8- ((3R, 4S) -4-ethylpyrrolidin-3-yl) -3H-imidazo [1,2-a] pyrrolo [2,3-e] pyrazine?
8- ((3R, 4S) -4 -ethylpyrrolidine-3-yl) -3H -imidazolo [1,2-a] pyrrolido [2,3-e] pyrazine is an organic compound. Its uses are quite extensive. In the field of pharmaceutical chemistry, this compound is often used as the key structure of active ingredients for the development of new drugs.
The structure and activity of organic compounds are closely related. The unique spatial configuration and chemical structure of this compound may have specific biological activities. It can be combined with specific targets in organisms, such as proteins, enzymes, etc., to regulate physiological processes in organisms. For example, it may be used as a potential drug to treat specific diseases, such as neurological diseases, cardiovascular diseases, or tumors. The way and strength of its binding to the target depends on its fine chemical structure, which is also the key to the research of pharmaceutical chemists.
Furthermore, in the field of materials science, such organic compounds may be applied to the research and development of organic Light Emitting Diodes (OLEDs), organic solar cells and other devices due to their unique photoelectric properties. Its special conjugate structure may enable it to have good charge transfer and luminescence properties, providing new opportunities for the innovative development of materials science.
In conclusion, 8- ((3R, 4S) -4 -ethylpyrrolidine-3-yl) -3H -imidazolo [1,2-a] pyrrolido [2,3-e] pyrazine has shown potential application value in many fields such as medicine and materials due to its unique chemical structure, opening up new paths for scientific research and technological innovation.
What are the synthesis methods of 8- ((3R, 4S) -4-ethylpyrrolidin-3-yl) -3H-imidazo [1,2-a] pyrrolo [2,3-e] pyrazine?
To prepare 8- ((3R, 4S) -4 -ethylpyrrolidine-3-yl) -3H -imidazolo [1,2-a] pyrrolido [2,3-e] pyrazine, there are many methods for its synthesis, and now I will describe one or two.
First, with pyrrolido [2,3-e] pyrazine as the group, you want to introduce ((3R, 4S) -4 -ethylpyrrolidine-3-yl). You can first take a suitable pyrrolido [2,3-e] pyrazine derivative and halogenate it at a specific location to increase its reactivity. This halogenated derivative reacts with a nucleophilic reagent containing (3R, 4S) -4-ethylpyrrolidine-3-yl) in an appropriate solvent and catalyzed by a base. Among them, the choice of solvent depends on the rate and yield of the reaction. Polar aprotic solvents such as N, N-dimethylformamide (DMF) and dimethyl sulfoxide (DMSO) are often the preferred choice because of their solubility in reactants and the dissociation and attack of nucleophilic reagents. The choice of base is also crucial. Inorganic bases such as potassium carbonate and sodium carbonate, or organic bases such as triethylamine and diisopropylethylamine, can be determined according to the specific reaction situation.
In addition, you can start with the construction of pyrrolidine rings. With appropriate nitrogen-containing and carbon-containing feedstocks, through a multi-step reaction, the pyrrolidine ring is first constructed, and ethyl is introduced on it to form the ((3R, 4S) -4-ethylpyrrolidine-3-yl) structural unit. Then, it is connected to the parent nucleus of imidazolo [1,2-a] pyrrolido [2,3-e] pyrazine. In this process, when constructing the pyrrolidine ring, chiral catalysts or chiral additives may be used to ensure the desired (3R, 4S) configuration. Chiral catalysts such as some chiral phosphine ligands and metal-formed complexes, chiral auxiliaries such as chiral amino acid derivatives, etc., can induce the reaction to a specific configuration.
Or, the coupling reaction catalyzed by transition metals. For example, in the coupling reaction catalyzed by palladium, the halogen-containing pyrrolido [2,3-e] pyrazine substrate is coupled with a reagent containing (3R, 4S) -4 -ethylpyrrolidine-3-yl) and having suitable functional groups (such as borate esters, tin reagents, etc.) in the presence of palladium catalysts, ligands and bases to form the target product. Among them, the activity of palladium catalysts, the electronic effect and the space effect of ligands all affect the selectivity and efficiency of the reaction.
However, all synthesis methods have their own advantages and disadvantages. Or multi-step reaction is required, the steps are cumbersome, and the yield is not high; or chiral control is difficult, resulting in impure configuration products; or expensive reagents and catalysts are required, which increases the cost of synthesis. Therefore, in practical application, the optimal method should be selected according to specific conditions and needs.
8- ((3R, 4S) -4-ethylpyrrolidin-3-yl) -3H-imidazo [1,2-a] pyrrolo [2,3-e] pyrazine What is the market price?
I don't know what the market price of "8 -% 28% 283R% 2C4S% 29 - 4 - ethylpyrrolidin - 3 - yl% 29 - 3H - imidazo% 5B1% 2C2 - a% 5Dpyrrolo% 5B2% 2C3 - e% 5Dpyrazine" is. This is a very professional and uncommon chemical, and its price is determined by many factors.
First, the difficulty of synthesis is also. If its preparation requires complicated steps, special raw materials and conditions, labor-intensive and laborious, the price will be high. On the contrary, if the synthesis is relatively simple, the price may be slightly lower.
Second, the amount of demand is related to the price. If there is strong demand in the fields of pharmaceutical research and development, chemical production, etc., and the supply is in short supply, the price will be high; if there is little demand, the price may be suppressed.
Third, purity is also the key. For high purity, the price is naturally high due to the high purification cost; for low purity, the price is slightly closer to the people.
Fourth, the market competition situation has an impact. If multiple suppliers compete, it is to compete for share, or to reduce prices for promotion; if it is exclusively supplied, the pricing may be more independent.
After searching all the classics and records I know, there is no exact record of the market price of this substance. Or because it is too novel and unique, it has not been widely circulated in the conventional market; or its application is limited to specific high-end research fields, and the price information is not disclosed. Therefore, it is difficult to determine its exact price.