3-Methoxy-2-sulfapyrazine

3-Methoxy-2-sulfamethylpyrazine has a wide range of uses. In the field of medicine, this compound is often a key raw material for the creation of antibacterial drugs. Due to its unique chemical structure, it can inhibit or kill many pathogenic microorganisms, such as bacteria and chlamydia. Based on it, carefully prepared and compatible, antibacterial agents can be prepared, which may save many patients from illness during clinical treatment.
In the field of pesticides, 3-methoxy-2-sulfamethylpyrazine has also emerged. With its specific effects on some harmful insects and fungi, it can be used to develop new pesticides. Such pesticides may be able to precisely act on target pests, ensuring the robust growth of crops and increasing yields while minimizing the impact on the environment, in line with the current trend of green agriculture development.
Furthermore, in the field of chemical synthesis, this substance is often used as an important intermediate. Through a series of chemical reactions, it can be converted into more complex organic compounds with unique functions. These compounds are of great value in many fields such as materials science and fine chemistry, or can give rise to new materials with excellent performance, such as those with special optical and electrical properties, thereby promoting the progress and innovation of related industries.

3-Methoxy-2-sulfamethylpyrazine, this is an organic compound. Its physical properties are very important and are related to many practical applications.
First, the appearance, usually, 3-methoxy-2-sulfamethylpyrazine is white to off-white crystalline powder. This color state is easy to identify and distinguish in many scenarios. In pharmaceutical preparation or chemical production, its purity and quality can be preliminarily judged.
Melting point is about 180-185 ° C. Melting point is one of the properties of the substance and is extremely critical for the identification of this compound. In laboratory or industrial production, by accurately measuring the melting point, it is possible to confirm whether the prepared or obtained substance is 3-methoxy-2-sulfamethylpyrazine, and its purity can also be evaluated. If the melting point of the sample deviates too much from the standard value, or suggests that there are impurities mixed in.
Solubility cannot be ignored. It is slightly soluble in water, which limits its application in aqueous systems. However, it is soluble in some organic solvents, such as dimethyl sulfoxide (DMSO), N, N-dimethylformamide (DMF). In organic synthesis or drug development, a suitable solvent needs to be selected according to its solubility to facilitate reaction or preparation. For example, in a synthetic reaction, selecting a suitable organic solvent can improve the solubility of the reactants, increase the reaction rate and yield; in pharmaceutical preparations, selecting a solvent that can dissolve the compound helps to prepare a uniform and stable pharmaceutical dosage form.
In addition, the compound has certain stability, but under extreme conditions such as strong acids, strong bases or high temperatures, decomposition or chemical reactions may occur. Knowing this stability, when storing and using 3-methoxy-2-sulfamidopyrazine, appropriate measures can be taken to avoid its deterioration and ensure its performance and efficacy.

The chemical stability of the 3-methoxy-2-sulfonamidopyrazine is related to many aspects. This substance has a unique molecular structure, methoxy and sulfonamido are combined on the pyrazine ring. Methoxy group, with its electron carrier characteristics, has an impact on the electron cloud distribution of the pyrazine ring, which can increase the electron cloud density on the ring and affect its reactivity to a certain extent.
In terms of stability, the pyrazine ring itself has a certain aromaticity and its structure is relatively stable. However, the existence of atoms such as nitrogen and sulfur in the sulfonamide group results in non-uniform charge distribution within the molecule due to electronegativity differences. This charge distribution may affect its interaction with external substances.
Under normal conditions, if the environment is relatively mild and there are no extreme conditions such as strong oxidizing agents and strong acids and bases, the chemical properties of 3-methoxy-2-sulfonamidopyrazine are relatively stable. The aromatic conjugate system of the pyrazine ring can resist a certain degree of chemical attack.
In case of strong oxidizing agents, the sulfur atom of the sulfonamide group may be oxidized, causing the molecular structure to change. In case of strong acids and bases, the sulfonamide group and methoxy group may also react such as hydrolysis, destroying the original structure of the molecule and losing its stability.
In summary, the chemical stability of 3-methoxy-2-sulfamethylpyrazine is not absolute and depends on the chemical conditions of the environment. In mild environments, it can maintain relative stability; in harsh chemical environments, it is prone to chemical reactions and structural changes.

To prepare 3-methoxy-2-sulfonylpyrazine, a conventional number method is used. First, pyrazine is used as a group, and methoxy is introduced first, so that pyrazine and halomethane can react under the catalysis of strong bases, such as sodium hydride as a base, in a suitable solvent such as N, N-dimethylformamide, the halogen atom of halomethane nucleophilic replaces hydrogen on the pyrazine ring to obtain methoxypyrazine. Then, methoxypyrazine is sulfonated with a sulfonating agent such as fuming sulfuric acid or chlorosulfonic acid under low temperature control, and the sulfonate group replaces hydrogen at a specific position to obtain the target product.
Second, pyrazine derivatives containing suitable substituents can be started. If 2-chloropyrazine is used as raw material, it is first reacted with sodium methoxide, and the chlorine atom is replaced by methoxy to form 2-methoxy pyrazine. Subsequently, by sulfonation means, such as concentrated sulfuric acid and an appropriate amount of catalyst, the methoxy group is introduced into the sulfonyl group at the appropriate temperature to obtain 3-methoxy-2-sulfonylpyrazine.
Third, from the heterocyclic compound with suitable functional groups, the pyrazine ring can be constructed through multi-step reaction and the desired substituent can be introduced. For example, through a series of reactions such as specific nitrogen and oxygen heterocycles, cyclization and substitution, the pyrazine structure is gradually established and methoxy and sulfonyl groups are introduced in sequence. However, there are many steps in this path, and the reaction conditions of each step need to be carefully adjusted to achieve higher yield and purity. Each method has its own advantages and disadvantages. The actual synthesis needs to be weighed according to factors such as the availability of raw materials, the ease of control of reaction conditions, and the purity requirements of the target product.

In today's world, it is difficult to know the price range of 3-methoxy-2-sulfonamidopyrazine on the market immediately. "Tiangong Kaiwu" contains mostly various methods of technological creation, and there is no detailed description of the price of such fine chemicals.
If you want to speculate on its price, you need to consider many reasons. First, the difficulty of preparing this compound. If the synthesis method is complicated, rare raw materials, harsh conditions, or multiple fine steps are required, the price will be high. Second, the use is wide and narrow. If it is mostly used in key medicine and high-end scientific research fields, although the demand may not be numerous, it is important and the price is not low; if it is only assisted by ordinary chemicals, the price may be slightly reduced. Third, the state of market supply and demand. If there is an oversupply, the merchant will sell his goods, and the price may decline; if there is a shortage of supply, the buyer will compete to buy, and the price will rise.
And the price of chemical products often varies from time to time. Different regions have different prices due to raw material costs, transportation tariffs, and tax policies. In addition, market conditions are changing rapidly, and fluctuations in raw material prices and the emergence of new technologies can cause their prices to fluctuate.
Therefore, based on existing information, it is difficult to determine the market price range of 3-methoxy-2-sulfamidopyrazine. To obtain an accurate figure, it is necessary to consult the chemical market information, consult industry experts, or refer to recent transaction data in order to obtain a more accurate price.