3 Bromo 2 Pyrazinecarboxylic Acid
pyridine pyrrole pyrazine piperidine piperazine

3-Bromo-2-pyrazinecarboxylic acid

    Specifications

    HS Code

    853601

    Chemical Formula C5H3BrN2O2
    Molar Mass 203.00 g/mol
    Appearance Solid (likely a white to off - white powder)
    Solubility In Water Low solubility (due to non - polar aromatic ring and relatively small polar groups)
    Melting Point Typically in a certain range (data may vary by source, around 180 - 190°C approximately)
    Pka There are acidic hydrogens (e.g., from the carboxylic acid group with pKa around 2 - 4 for the carboxylic acid moiety)
    Density Data may vary, but in the range of 1.8 - 2.0 g/cm³ estimated based on similar bromo - aromatic carboxylic acids
    Reactivity Reactive at the carboxylic acid group (can form esters, amides etc.), and at the bromine site for substitution reactions
    Uv Vis Absorption Absorption in the UV region due to the aromatic pyrazine ring

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    General Information
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    Frequently Asked Questions

    As a leading 3-Bromo-2-pyrazinecarboxylic acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the chemical properties of 3-bromo-2-pyrazine carboxylic acid?
    3-2-pentyne carboxylic acid, which is a compound with unique properties. Its chemical properties are as follows:
    From an acidic point of view, due to the presence of the carboxyl group (-COOH) in the molecule, it is acidic. The carboxyl group can be generated in solution, and it can emit hydrogen (H 🥰), which exhibits the generality of acids. For example, it can be neutralized and reversed. Like acetic acid, it can oxidize sodium (NaOH) to form a phase of carboxylic acid and water. The inverse equation is roughly: 3-2-pentyne carboxylic acid + NaOH → 3-2-pentyne carboxylic acid + H 2O O.
    In terms of chemical properties, the molecule contains carbon-carbon triglycerides (alkynyl groups), which do not harmonize and give the compound a lot of special anti-activity. First, it can generate an addition inverse. Taking bromine water as an example, carbon-carbon triglycerides can add bromine molecules to make bromine water fade. This is a common method of non-reconciliation. In contrast, bromine atoms are added one by one to three carbon atoms to form bromine-containing derivatives. Furthermore, under specific catalytic conditions, alkynyl groups can be generated and reacted, and gradually added to form carbon-carbon compounds. The addition of carbon-carbon triglycerides can be reduced to carbon and carbon groups.
    The existence of the alkyl group (-OH) also depends on its chemical properties. The alkyl group can be substituted and reversed, such as the alkyl group (such as HBr). The alkyl group is replaced by a bromine atom to form a phase. At the same time, the alkyl group can be esterified. Under the action of sulfuric acid and other catalysts, the alkyl alcohol compound can be reacted to generate ester water. This reaction is often used in the synthesis of ester compounds.
    In addition, 3-2-pentyne carboxylic acid molecules also have mutual effects. The activity of the alkynyl group is affected by the activity of the carboxyl group, and the carboxyl group can also affect the activity of the alkynyl group, resulting in the integration of general monofunctional compounds.
    What are the common synthesis methods of 3-bromo-2-pyrazine carboxylic acid?
    3-Hydroxy-2-pentanoic acid is an important intermediate in organic synthesis. The common synthesis methods are as follows:
    ** First, take glutaric acid anhydride as the starting material **
    Take an appropriate amount of glutaric acid anhydride and place it in the reaction kettle. Using ethyl acetate as the solvent, add a certain amount of sodium metal as a reducing agent. Under the condition of low temperature and continuous stirring, the reduction reaction of sodium metal and glutaric acid anhydride occurs. In this process, the sodium metal provides electrons, and the glutaric acid anhydride is gradually reduced to form an intermediate product. Subsequently, dilute sulfuric acid solution is slowly added dropwise to the reaction system for acidification, which promotes the intramolecular rearrangement and dehydration of the intermediate product, and finally obtains 3-hydroxy- 2-pentano The raw materials of this method are relatively easy to obtain, and the reaction conditions are relatively mild, but the steps are slightly cumbersome, and the reaction conditions of each step need to be precisely controlled to ensure a higher yield.
    ** Second, using diethyl malonate and halogenated acetone as raw materials **
    First, diethyl malonate and sodium alcohol are mixed in proportion, and react in ethanol solvent to form a sodium salt of diethyl malonate. This sodium salt has strong nucleophilicity, and then halogenated acetone is slowly added to the reaction system. At an appropriate temperature, the nucleophilic group of the sodium salt of diethyl malonate attacks the carbon atom attached to the halogenated atom of halogenated acetone, and a nucleophilic substitution reaction occurs to form a substitution product. Afterwards, the product is hydrolyzed, the ester group is hydrolyzed under alkaline conditions, then acidified, and finally decarboxylated by heat to obtain 3-hydroxy- 2-pentenoic acid. The reaction conditions of this route are relatively easy to control, and the yield is considerable. However, halogenated acetone has certain toxicity and volatility, and safety protection should be paid attention to during operation.
    ** Third, using ethyl acetoacetate and formaldehyde as raw materials **
    In the presence of an alkaline catalyst such as sodium ethyl alcohol, the active methylene acetoacetate and formaldehyde undergo hydroxyaldehyde condensation reaction. During the reaction, the methylene of ethyl acetoacetate forms carbonyl anions under the action of bases, attacking the carbonyl carbon of formaldehyde to form β-hydroxy compounds. Subsequently, the β-hydroxy compound undergoes a dehydration reaction under acidic conditions to form an unsaturated carbonyl structure. Finally, the product is subjected to post-treatment steps such as ester hydrolysis and acidification to obtain the target product 3-hydroxy-2-pentenoic acid. This method has common raw materials and is easy to operate, but the reaction selectivity needs to be optimized by controlling the reaction conditions and the amount of catalyst to reduce the occurrence of side reactions.
    3-Bromo-2-pyrazine carboxylic acid is used in what fields?
    3-3-2-pentyne carboxylic acid, this is a special compound, which has extraordinary applications in many fields.
    In the field of research, it can be used as an important synthetic material. Due to its unique characteristics, it can be used for a wide range of reactions, which can be used to create a molecular framework of biologically active materials. With ingenious modification, it can be used for specific physiological effects of materials, such as the treatment of certain diseases, or as a new material, to help develop new high-efficiency and low-toxicity products.
    In the field of materials, it also has a phase value. Or it can be used as a synthetic raw material for functional materials, such as polymerization and reaction, etc., and can be used for special properties of materials. For example, by making materials with specific adsorption, chemical or optical properties, the research of new functional materials will open up new avenues.
    Furthermore, in the field of chemical synthesis research, it makes a special reaction, which can lead to a series of special reactions, providing new methods for synthesizing chemical compounds with special properties. Chemists can take advantage of their unique properties to develop new synthetic pathways, and use conventional methods to obtain compounds to promote the development of synthetic processes.
    In this regard, 3-2-pentyne carboxylic acid, materials and chemical synthesis, etc., are all areas of great power, and the technological progress of each field is unique.
    What is the market price of 3-bromo-2-pyrazine carboxylic acid?
    3-% hydroxy-2-pentenoheptanoic acid, this substance is extraordinary, but the price between the markets is geometric. I have checked the ancient books in detail to get some eyebrows.
    In today's world, these compounds are mostly used in all kinds of delicate medicines and quirky chemical processes. Its preparation requires several complicated processes, and the raw materials are very rare. The process must also be accurate and accurate, which is costly.
    Looking at the example of transactions between various markets, the price per gram of high quality is about a thousand gold. If the quality is slightly inferior, it also costs hundreds of gold to buy one gram. Because of the difficulty of preparation and the high demand, the price is so high.
    Remembering the past, in a secret volume, I saw a record of something like this. At that time, the preparation method was far less delicate than it is today, and its degree of preciousness was also comparable to that of ordinary things. Although the years have passed, the preparation technology has become more and more exquisite, but the raw materials are rare and the processes are complicated, and they have not been greatly changed, but the price is still high.
    The merchants in the city all regard this as a rare thing to live in. There are people who are good at business, but because of the sale of this thing, they are rich. However, there are also those who cannot ask for it, but they sigh. The market value of this 3-% hydroxy-2-pentenoheptanoic acid is actually due to a number of intertwined reasons, which cannot be hidden by a single word.
    What are the storage conditions for 3-bromo-2-pyrazine carboxylic acid?
    3-3-2-pentenoheptanoic acid is a rare ingredient. Its storage is very important, and it can be properly followed to ensure that its active products are safe. According to the principles of "Tiangong Wuwu", the appropriate storage parts are as follows:
    The first heavy environment is dry. This ingredient is damp, and the damp is easy to cause its hydrolysis or invasion by microorganisms, and its activity is high. Therefore, it is suitable to be placed in dry places and avoid dry places, such as cellars, water buildings, etc. It can be placed in the air, or used to help dry the air, such as quicklime, water sulfuric acid, etc., to absorb and remove the surrounding air.
    The control of the secondary temperature. It is appropriate to store in a cool environment, avoid high temperature. High temperature can promote its transformation and reverse speed up, causing decomposition and waste. The optimum temperature range is 2 to 8 degrees Celsius, and it can be kept in an ice cellar or a refrigerated place instead. If you refrigerate the parts, you should also keep them in a place where they are not exposed to direct sunlight, such as the surface of a house or a cave, so that the temperature will not be high.
    Furthermore, you need to pay attention to avoiding light. Light, especially ultraviolet light, can cause photochemical reactions and destroy their properties. Therefore, it is advisable to use dark glass or opaque materials, such as ceramic jars, dark glass bottles, etc., and store them with less light to prevent them from being exposed to light.
    In addition, air insulation is also important. Oxygen in the air can cause oxidation and reduce activity. If it is stored, it can be sealed in a container, and it can be less empty. If there are any components, the container can be filled with inert materials, such as nitrogen, to expel oxygen, which is more conducive to preservation.
    In addition, the storage of 3-2-pentenoheptanoic acid is also a factor of dryness, coolness, light protection, and air isolation, so as to improve its activity and make it effective in such domains.