3 Aminopyrazine 2 Carboxylic Acid
pyridine pyrrole pyrazine piperidine piperazine

3-aminopyrazine-2-carboxylic acid

    Specifications

    HS Code

    467167

    Name 3-aminopyrazine-2-carboxylic acid
    Molecular Formula C5H5N3O2
    Molecular Weight 139.11 g/mol
    Appearance Solid (usually powder or crystalline form)
    Physical State At Room Temperature Solid
    Melting Point 248 - 252 °C (reported value may vary slightly)
    Solubility In Water Moderately soluble (due to polar functional groups)
    Solubility In Organic Solvents Soluble in some polar organic solvents like DMSO, less soluble in non - polar solvents
    Pka For Acidic And Basic Groups pKa of carboxyl group around 2 - 3 (approximate, for acidic dissociation), pKa of amino group around 9 - 10 (approximate, for basic dissociation)
    Odor Odorless or very faint odor
    Color Typically white to off - white

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    General Information
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    Frequently Asked Questions

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    What is the main use of 3-aminopyrazine-2-carboxylic acid?
    3-Aminopyridine-2-carboxylic acid, an organic compound. It has a wide range of main uses and plays an important role in many fields.
    In the field of medicine, it can act as a key intermediate in drug synthesis. Due to its specific chemical structure and activity, it can participate in the construction of a variety of drug molecules. With its structural properties, it can react with other compounds to generate drugs with specific pharmacological activities. For example, in the development of some innovative drugs targeting specific disease targets, 3-aminopyridine-2-carboxylic acids can be used as starting materials to construct complex drug molecular structures with therapeutic efficacy through a series of chemical reactions, providing new avenues and possibilities for the treatment of human diseases.
    In the field of materials science, it also plays an important role. It can be used to prepare functional materials, such as some materials with special optical and electrical properties. Due to the functional groups such as amino and carboxyl groups it contains, it can chemically bond or interact with other materials, thus giving the material unique properties. For example, when preparing organic Light Emitting Diode (OLED) related materials, 3-aminopyridine-2-carboxylic acid can participate in the synthesis of materials, optimize the luminous properties of materials, improve the luminous efficiency and stability of OLEDs, and then promote the development of display technology.
    In the field of organic synthesis, it is a commonly used synthetic block. Chemists use its special structure to construct more complex organic compounds through various organic reactions, such as esterification reactions, amidation reactions, etc. It is like a key piece in building a block, providing a foundation for the synthesis of various organic molecules with specific structures and functions, and helping organic synthetic chemistry to continuously expand new fields and create new compounds.
    What are the synthesis methods of 3-aminopyrazine-2-carboxylic acid?
    There are various ways to synthesize 3-amino-2-naphthalic acid.
    First, it can be obtained from naphthalene anhydride through a series of steps such as nitrification, reduction, and hydrolysis. First, the naphthalene anhydride is treated with a nitrifying agent under appropriate conditions to introduce nitro groups. This process requires attention to factors such as reaction temperature and reagent ratio to ensure that nitro groups are introduced in suitable positions. Subsequently, the nitro group is reduced to amino groups using suitable reducing agents, such as iron powder and sodium sulfide. During operation, the reaction conditions should be controlled to avoid excessive reduction or other side reactions. Finally, through the hydrolysis step, the naphthalene anhydride derivative is converted into 3-amino-2-naphthalic acid. The choice of hydrolysis conditions is also crucial, which affects the purity and yield of the product.
    Second, 2-naphthol is used as the starting material. First, 2-naphthol is sulfonated, and a sulfonic acid group is introduced. The positioning of the sulfonic acid group can affect the subsequent reaction. After alkali melting, the sulfonic acid group is converted into a hydroxyl group, and then the amino group is replaced under certain conditions by an appropriate amination reagent, and then the target product is obtained. This route requires attention to the optimization of the reaction conditions at each step. The type, dosage and temperature of the sulfonating agent during sulfonation, the alkali concentration, reaction time and temperature during alkali melting, and the reagent activity and reaction environment during amination will all affect the synthesis.
    Third, some novel synthesis strategies can also be adopted. For example, by means of the coupling reaction catalyzed by transition metals, suitable halogenated naphthalene derivatives and reagents containing amino groups and carboxyl groups can be used under the catalysis of transition metal catalysts such as palladium and copper to achieve the formation of carbon-carbon or carbon-nitrogen bonds, thereby constructing the structure of 3-amino-2-naphthalenecarboxylic acid. This method requires more stringent reaction conditions, and the selection of catalysts, the design of ligands, and the screening of reaction solvents all need to be carefully considered to improve the efficiency and selectivity of the reaction.
    What are the physical and chemical properties of 3-aminopyrazine-2-carboxylic acid?
    3-Aminobutyric acid-2-succinic acid, also known as gamma-aminobutyric acid-2-succinic acid, the following are its physical and chemical properties:
    The appearance of this substance is often in the state of white crystalline powder, like fine snow, pure and delicate. Viewed in natural light, it can be seen flickering shimmer, like a natural crystal. Its smell is very small, close to the fine smell, only a trace of elegant taste, not pungent, not strong, like an elegant elf hidden in the world.
    Its solubility is quite characteristic, soluble in water, just like ice and snow merging into a stream, quietly seamless, and can blend with water to form a uniform solution; however, in most organic solvents, such as ethanol, ether, etc., it is difficult to dissolve, just like the barrier between oil and water, distinct. This characteristic is due to the unique structure of its molecules, the polar part attracts water molecules, while the non-polar part is incompatible with organic solvents.
    In terms of stability, under conventional environmental conditions, it is quite stable, and can maintain its own structure and properties for a long time. It is like a calm person who sticks to himself in the hustle and bustle of the world. However, in the case of strong acids and alkalis, it is like a humble gentleman encountering a violent storm, the structure is easily damaged, and the properties are also changed. In a high temperature environment, it is difficult to maintain stability, and the internal structure of the molecule will undergo reactions such as rearrangement and decomposition, just like a building collapsing, completely unrecognizable.
    Its melting point has a fixed number, and after rigorous determination, it is about a certain temperature range. When heated to this temperature, the crystal structure originally arranged in a regular arrangement begins to disintegrate, and the solid state gradually changes to the liquid state, just like melting snow and melting, ushering in a change in shape.
    In chemical reactions, it is like a multi-faceted expert, and the amino and carboxyl groups in the molecule have active chemical properties. Amino groups can be neutralized with acids, just like yin and yang, forming corresponding salts; carboxyl groups can be esterified with alcohols to generate ester compounds with special flavors, adding a touch of color to their chemical properties.
    What is the price of 3-aminopyrazine-2-carboxylic acid in the market?
    In today's market, the price of 3-aminobutyric acid-2-carboxylic acid varies depending on the purity of the product, the demand for supply, and the method of preparation.
    If it is for ordinary industrial use, its purity rate is slightly lower, and the supply is more abundant. The production method or the common chemical synthesis technique, the price per kilogram or in the tens to hundreds of dollars. This is because industrial users are not as demanding in quality as the pharmaceutical and food industries, so the production is easy and the price is also low.
    As for the pharmaceutical grade, the demand for purity is extremely high, and strict regulations must be met. The production or biological fermentation method is used to achieve its high purity and biological activity. This grade of products, because of the difficulty of making and the harsh inspection, the price is high, or to thousands of gold per kilogram, or even more than 10,000 yuan. Covering medicine is related to human life, and the quality must be accurate. Although the price is high, it cannot be saved.
    For food grade, the quality must also reach a certain standard to meet the food safety regulations. The price is often between industrial and pharmaceutical grade, or hundreds to thousands of gold per kilogram. Because food users need to be safe and suitable, and they also consider the cost, the price varies according to the quality and market demand.
    In addition, the supply and demand of the city also has a loud noise in the price. If you ask for more supply and less supply, the price will tend to rise; otherwise, if the supply exceeds the demand, the price may fall. And the laws and policies of the new system can also make the price fluctuate. It is to know the exact price, to study the real-time situation of the market, and to visit various merchants and business people to obtain the true price.
    What are the relevant application fields of 3-aminopyrazine-2-carboxylic acid
    3-Hydroxybutyric acid-2-heptanoic acid is a class of compounds with a specific chemical structure. The two have related applications in many fields, and the following numbers are briefly listed:
    - ** Pharmaceutical R & D field **: The specific structure of hydroxy and heptanoic acid may provide an opportunity for the creation of medicine. Many drug molecules rely on specific chemical groups to achieve precise binding to biological targets. For example, in the study of analgesic drugs, such compounds may be structurally modified to conform to neurotransmitter receptors, by modulating nerve signaling to achieve pain relief. When exploring anti-inflammatory drugs, they may be able to regulate the expression of inflammation-related cytokines by virtue of their structural properties, exhibiting anti-inflammatory activity and assisting the development of new anti-inflammatory drugs. < Br > - ** Material Science Field **: Its structural characteristics or endow materials with unique properties. In the preparation of polymer materials, introducing such compounds into the polymer main chain or side chain can change the hydrophobicity and mechanical properties of the material. For example, when preparing biodegradable materials, adding this compound may regulate the degradation rate of the material and meet the needs of tissue engineering scaffolds and other fields for material degradation in vivo at a specific time; in the field of coatings, it may improve the adhesion and durability of coatings and expand its application range.
    - ** Biochemical Research Field **: Can be used as a tool molecule for biochemical research. Because they are similar in structure to some natural substances in living organisms, or can participate in specific biochemical reactions, they can help researchers explore biological metabolic pathways. For example, in the study of fatty acid metabolism, by tracking the metabolic trajectories of such compounds in organisms, the detailed mechanisms of fatty acid metabolism can be deeply elucidated, providing key clues for understanding physiological and pathological processes.