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What are the chemical properties of 3- [ (5-chloropyridine-2-yl) carbamoyl] pyrazine-2-carboxylic acids
The chemical properties of 3- [ (5-hydroxy-2-yl) ethoxyethyl ether group] ethyl-2-carboxylic acid are acidic, because it contains carboxyl groups, it can neutralize with bases, and react with raw salts and water. In case of sodium hydroxide, it forms the corresponding carboxylate and water.
And this compound is esterified, the carboxyl group can be esterified with alcohol under acid catalysis, and the raw ester and water. Taking ethanol as an example, the corresponding ester and water are obtained.
And because of its ether bond, it is relatively stable and does not react easily at room temperature. However, under strong acid or high temperature, the ether bond can be broken and the reaction occurs. < Br >
Its hydroxyl groups are also active and can be oxidized to form aldehyde or carboxyl groups in case of strong oxidants.
The chemical properties of this compound make it widely used in organic synthesis, and can be used as raw materials to make esters, fragrances, pharmaceutical intermediates, etc. It has an important position in the chemical and pharmaceutical fields.
What are the main uses of 3- [ (5-chloropyridine-2-yl) carbamoyl] pyrazine-2-carboxylic acids
3 - [ (5-aldehyde-2-hydroxy) ethoxyacetamido] valeric acid-2-naphthoic acid, the main uses of this compound are as follows:
In the field of medicinal chemistry, such compounds containing a variety of specific functional groups are often used as potential lead compounds. The aldehyde group has high reactivity and can participate in a variety of chemical reactions, such as condensation reactions with amine compounds to form a Schiff base structure with specific pharmacological activities, which is expected to be used in the development of antibacterial, anti-tumor and other drugs. Hydroxyl groups can not only enhance the hydrophilicity of compounds, which is conducive to transport and metabolism in vivo, but also act as hydrogen bond donors or receptors to form hydrogen bond interactions with biological macromolecules (such as proteins, nucleic acids), thus affecting their activity and function. It is often used to design small molecule inhibitors targeting specific targets.
In terms of materials science, this compound can be used as a functional monomer for the synthesis of new polymer materials. Its unique structure endows the material with special properties. For example, it is introduced into the polymer main chain or side chain through polymerization reaction. Using the interaction of functional groups such as aldehyde groups and hydroxyl groups with other materials to improve the surface properties, compatibility or cross-linking properties of the material, it is used to prepare separation membrane materials with special adsorption properties, or tissue engineering scaffold materials with good biocompatibility.
In organic synthesis chemistry, it is an important intermediate that can build more complex compound structures through a series of organic reactions. Using it as a starting material, using the reactivity of valeric acid and naphthalic acid, esterification, amidation and other reactions are carried out to expand the structural diversity of molecules, providing a key step for the synthesis of organic compounds with specific functions and structures, and assisting the development and synthesis of new organic functional materials and drugs.
What is the synthesis method of 3- [ (5-chloropyridine-2-yl) carbamoyl] pyrazine-2-carboxylic acid
To prepare 2-carboxyl-3- [ (5-nitropyridine-2-yl) carbamoyl] pyridine, the synthesis method is as follows:
Take 5-nitropyridine-2-amine and react with suitable reagents to introduce carbamoyl groups. This step requires mild reaction conditions, and sensitive groups such as anti-nitro groups are affected. For example, phosgene or its replacement reagents are slowly added dropwise to a solution containing 5-nitropyridine-2-amine in an organic solvent such as dichloromethane at low temperature, and an organic base such as triethylamine is bound to an acid to promote the reaction towards the formation of aminoformyl derivatives.
After the aminoformyl group is introduced, the carboxylation reaction is carried out. A suitable carboxylation reagent, such as carbon dioxide, can be used to react in a suitable solvent system such as tetrahydrofuran in the presence of a strong base such as sodium hydride. During the reaction, attention should be paid to controlling the temperature and reaction time to ensure that carboxylation selectively occurs at specific positions of pyridine to obtain the target 2-carboxyl-3- [ (5-nitropyridine-2-yl) carbamoyl] pyridine.
After each step of the reaction, the product needs to be separated and purified from the reaction mixture by suitable separation and purification methods, such as column chromatography, recrystallization, etc., to improve the purity of the product and meet the needs of subsequent reactions or applications. The entire synthesis process requires fine operation and close monitoring of the reaction process to obtain the ideal yield and purity.
What is the market outlook for 3- [ (5-chloropyridine-2-yl) carbamoyl] pyrazine-2-carboxylic acids?
The market prospect of Guanfu 3 - [ ( 5 -cyanoethyl ether group] isotropic-2-carboxylic acid is related to many aspects.
Now, this 2-carboxylic acid is used in various fields. In the field of medicine, it can be a key raw material for the synthesis of many drugs. Because of its specific chemical structure and activity, it can participate in delicate reactions to produce drugs that have curative effects on diseases. Taking a certain type of antibacterial drug as an example, the characteristics of 2-carboxylic acid can help it act precisely on the target of bacteria and exert the antibacterial effect.
In the materials industry, it also has its own unique features. Polymer materials with specific properties can be polymerized with other substances through special processes. Such materials may have better flexibility and heat resistance, and can be used in electronics, automotive interiors and other fields.
As for market demand, with the advance of science and technology and the continuous deepening of pharmaceutical research and development, the demand for 2-carboxylic acid for new drugs may be on the rise. And the material industry's demand for high-performance materials will also drive the increase in the amount of 2-carboxylic acid.
However, its challenges also need to be observed. The process of synthesizing this 2-carboxylic acid may be complicated, and cost control is not easy. If the cost remains high, it may hinder its market expansion. And the market competition is fierce, similar alternative products may also covet their market share.
In summary, 3 - [ ( 5 -cyanoethyl to its - 2 - group) cyanoethyl ether group] iso-2 - carboxylic acid Although the prospect is promising, it also needs to solve problems such as process and cost in order to navigate the market without hindrance and win a broad development world.
What are the precautions for the use of 3- [ (5-chloropyridine-2-yl) aminoformyl] pyrazine-2-carboxylic acid
3- [ (5-hydroxy- 2-yl) ethoxyethyl ether] glutaric acid-2-carboxylic acid has many things to pay attention to during use.
Bear the brunt, this compound has a specific chemical activity, and it must be handled with caution. There are specific functional groups in its molecular structure, which meet with other chemical substances, or cause unpredictable chemical reactions. If it encounters with strong oxidizing agents, or causes severe changes due to redox reactions, or even causes danger. Therefore, when storing and using, be sure to carefully observe its chemical properties and keep away from potential reactive substances.
Furthermore, it is related to safety protection. Because they are organic compounds, some organic compounds are toxic or irritating. When exposed to this compound, personal protection should be taken, such as wearing suitable protective gloves, protective glasses and masks. In case of accidental contact with the skin or eyes, rinse with plenty of water immediately and seek medical attention in a timely manner.
Temperature and environmental factors should not be underestimated. If the temperature is too high, the compound may decompose and evaporate, change its chemical properties, affect the use effect, and cause safety accidents in serious cases. Therefore, it should be stored in a cool, dry and well-ventilated place, away from direct sunlight and high temperature environments.
When taking this compound, accurate dose control is essential. Due to its chemical activity, dose deviation or reaction results are very different, affecting the effectiveness of the experiment or production. Use precise measuring tools and strictly follow the established operating procedures.
During operation, good ventilation conditions are indispensable. If the compound volatilizes to produce gas, it accumulates in a limited space, or affects the air quality, threatening the health of the operator. Ensure smooth ventilation in the operation area, and can discharge volatile gas in time to reduce latent risk.