2-Chlorl-3-methoxy pyrazine

2-Chloro-3-methoxypyrazine is widely used and has important applications in many fields such as chemical industry and medicine.
In the chemical industry, it is often a key intermediate in organic synthesis. Due to its unique chemical structure, a variety of organic compounds can be derived through many chemical reactions. If it reacts with specific reagents, it can generate pyrazine derivatives with more complex structures. Such derivatives are used in the field of materials science or can be used as raw materials for special functional materials. For example, they are used to prepare materials with unique electrical and optical properties, which contribute to the development of electronic devices and optical instruments.
In the field of medicine, its significance is also extraordinary. Numerous studies have shown that the compounds synthesized on this basis have potential biological activities. Or they can be used as lead compounds, and new drugs can be developed through structural modification and optimization. For example, for specific disease targets, drug molecules that fit them can be designed and synthesized, or they are expected to be used to treat cardiovascular diseases, nervous system diseases, etc., and contribute to human health.
Furthermore, in the field of pesticides, 2-chloro-3-methoxypyrazine also has room for exploration. Pesticides prepared from it as a starting material may have high efficiency, low toxicity, and environmentally friendly characteristics. They have significant control effects on crop diseases and pests, and have little negative impact on the ecological environment, which is conducive to sustainable agricultural development. In conclusion, although 2-chloro-3-methoxypyrazine is an organic compound, its potential in various fields cannot be underestimated.

2-Chloro-3-methoxypyrazine is one of the organic compounds. Its physical properties are as follows:
Looking at its appearance, under room temperature and pressure, it is mostly colorless to light yellow liquid, with a clear and transparent texture. This state is easy to observe and operate, and is easy to control in many chemical reactions and industrial processes.
The smell of smell has a special smell, but it is not pungent and intolerable, but a unique and identifiable smell. This smell may be determined by its molecular structure and can also be used as a basis for identification in practical applications.
As for the boiling point, it is in a specific temperature range. The value of the boiling point is related to the state change during operations such as heating or distillation, and is crucial for separation and purification processes. When this boiling point is reached, 2-chloro-3-methoxypyrazine will change from liquid to gaseous state, so that it can be separated from other substances with different boiling points.
Melting point is also defined accordingly. The level of melting point affects its physical morphology at different temperatures. Below the melting point, the compound will solidify into a solid state. This property needs to be considered in storage and transportation to ensure its morphological stability.
In terms of solubility, it has certain solubility in common organic solvents such as ethanol and ether. This property makes it possible to use such solvents as reaction media in chemical reactions to promote the progress of the reaction. In water, its solubility may be limited, and this difference also affects its behavior and application in different environments.
Density is also one of its important physical properties. Compared with water and other common liquids, its density has a specific value. This value is of great significance in operations such as mixing and delamination, which can be used to judge its position and distribution in the mixture.
The physical properties of 2-chloro-3-methoxypyrazine are of great significance in many fields such as organic synthesis and medicinal chemistry, providing a basic basis for related research and applications.

The chemical stability of 2-chloro-3-methoxypyrazine is related to many aspects. Under normal temperature and pressure, the compound is generally stable without special conditions.
Looking at its structure, the chlorine atom and methoxy group are connected to the pyrazine ring. Chlorine atoms have certain electronegativity, which can affect the electron cloud distribution of the pyrazine ring, resulting in different chemical activities. Methoxy is a power supply group, which can change the electron cloud density of the pyrazine ring, making it unique in some reactions.
In common organic reaction environments, this compound may participate in nucleophilic substitution reactions, because chlorine atoms can be replaced by nucleophilic reagents. However, the difficulty of this reaction is closely related to the reaction conditions, such as reaction temperature, solvent properties, and nucleophilic reagent activity.
In air, if there are no special conditions such as light, it is relatively stable and difficult to react quickly with oxygen. In case of extreme conditions such as high temperature and open flame, or due to the breaking of chemical bonds in the structure, it will decompose and other reactions.
In an acid-base environment, the stability is also affected. In an acidic environment, the nitrogen atom of the pyrazine ring may protonate, changing the electronic structure of the molecule, which in turn affects its reactivity; in an alkaline environment, the nucleophilic substitution reaction of the chlorine atom may occur more easily. Overall, the chemical stability of 2-chloro-3-methoxypyrazine is acceptable under normal and mild conditions, but its structure and properties may be greatly changed under special reaction conditions or extreme environments.

The synthesis method of 2-chloro-3-methoxypyrazine, although the ancient book "Tiangong Kaiwu" does not contain this specific synthesis, it can be deduced by traditional chemical process concepts.
To synthesize 2-chloro-3-methoxypyrazine, one method can start from pyrazine. First, the pyrazine is methoxylated with a specific reagent under suitable conditions. In the past, the chemical industry often used trona and alcohols to introduce groups by simple methods such as high temperature co-heating. Here, a mild base can be found and used together with a methoxy reagent for pyrazine, so that the methoxy group is connected to the third position of the pyrazine ring.
Then, chlorination is carried out. Although there are no modern fine chlorination reagents in ancient times, common chlorination sources such as sulfuryl chloride and chlorine gas can be used. Take sulfuryl chloride as an example, in a suitable solvent, such as ethers or halogenated hydrocarbons, under appropriate temperature and catalytic conditions, the chlorine atom is substituted for the hydrogen at the 2 position to obtain 2-chloro-3-methoxypyrazine.
Or another route can be followed, using raw materials containing suitable substituents to form a pyrazine ring through cyclization reaction. For example, select a methoxy group and a chain compound that can be converted into a chlorine atomic group, and cyclize and condense under the action of an acid, base or metal catalyst. Among them, the choice of catalyst is very important. In ancient times, natural ores and metal oxides were used as catalysts. Nowadays, accurate and efficient modern catalysts can be selected to promote the reaction to generate 2-chloro-3-methoxypyrazine, and improve the yield and purity.

I look at your question, but I am inquiring about the price range of 2-chloro-3-methoxypyrazine in the market. However, the price of this chemical often varies due to many factors.
First, the supply and demand situation, if there are many people who want it, but the supply is small, the price will be high; if the supply exceeds the demand, the price will decrease. Second, the quality is divided into high purity, high price, slightly inferior price. Third, the source is different, the price of local products and imported products may be different. Fourth, the purchase quantity also affects it, and the price can be negotiated if the batch is large.
In the current market conditions, the price of 2-chloro-3-methoxypyrazine ranges from tens to hundreds of yuan per gram. If it is industrial grade, the purity is slightly lower, and the purchase quantity is quite large, the price per gram may be in the tens of yuan; if it is high purity, it is suitable for scientific research and other essential places, and the price per gram may reach hundreds of yuan.
However, this is only a rough estimate. The market is volatile, and the price is easy at any time. If you want to get a definite price, you should consult chemical raw material suppliers, chemical reagent manufacturers, etc., and the real-time market shall prevail.