2-Bromo-5H-pyrrolo[2,3-b]pyrazine

2 - Bromo - 5H - pyrrolo [2,3 - b] pyrazine is an organic compound whose physical properties are described below.
Looking at its properties, under normal temperature and pressure, it is mostly a solid state, usually a crystalline solid. This is caused by the intermolecular force to form a regular arrangement. This crystalline form contributes to the stable existence of the compound and also shows advantages during storage and transportation.
As for the melting point, after many experiments, the melting point of this compound is about a specific range. The value of the melting point reflects the strength of the intermolecular force. A higher melting point means that the intermolecular force is stronger. To convert it from a solid state to a liquid state, more energy needs to be supplied to overcome this force. This property is of great significance in the process of separation, purification and identification of compounds, and its purity can be determined by melting point measurement.
In terms of boiling point, under specific pressure conditions, there is also a corresponding value. The level of boiling point is closely related to molecular structure, molecular weight and intermolecular forces. Knowing the boiling point, in separation operations such as distillation, the appropriate temperature can be set accordingly to achieve the purpose of effective separation.
In terms of solubility, 2-Bromo-5H-pyrrolo [2,3-b] pyrazine exhibits a certain solubility in organic solvents such as common ethanol and dichloromethane. This is due to the interaction between the molecules of organic solvents and the molecules of the compound, such as van der Waals forces, hydrogen bonds, etc., which can promote its dissolution. In water, its solubility is poor. Due to the difference between the polarity of water molecules and the molecular structure of the compound, the interaction force is difficult to overcome the strong hydrogen bonds between water molecules, so it is not easy to dissolve.
In addition, the density of the compound is also an important physical property. Density reflects the mass of a substance in a unit volume, and has an important impact on its space and mass relationship in practical applications. Accurate determination of density plays a key role in the measurement and formulation design of materials in the fields of chemical production, drug research and development, etc.
The above physical properties are all indispensable elements for the study of 2-Bromo-5H-pyrrolo [2,3-b] pyrazine, and play an important role in its synthesis, application and related research processes.

2 - Bromo - 5H - pyrrolo [2,3 - b] pyrazine is an organic compound with unique chemical properties and is quite interesting.
This compound has the characteristics of halogenated aromatics, in which bromine atoms are active and can participate in various chemical reactions. For example, in nucleophilic substitution reactions, bromine atoms are easily replaced by nucleophiles such as hydroxyl (-OH) and amino (-NH ²). Due to the large electronegativity of bromine atoms, the carbon-bromine bond connected to the carbon atom has a certain polarity, and the carbon atom is partially positively charged and vulnerable to attack by nucleophiles.
At the same time, the compound contains the structure of pyrrole-pyrazine, and both pyrrole and pyrazine are nitrogen-containing heterocycles. The pyrrole ring is electron-rich and prone to electrophilic substitution reactions, such as halogenation, nitration, sulfonation, etc. The pyrazine ring is relatively electron-deficient and can react with nucleophiles. The pyrrole-pyrazine structure formed by the connection of the two makes the entire molecular electron cloud unique, which affects the reactivity and selectivity.
In addition, 2-Bromo-5H-pyrrolo [2,3-b] pyrazine may have certain aromaticity. Aromaticity imparts additional stability to the compound and affects its physical and chemical properties. Due to its aromaticity, it prefers to maintain a cyclic conjugate structure under certain conditions, and follows specific rules when participating in the reaction to maintain the stability of the aromatic system.
Under appropriate conditions, 2-Bromo-5H-pyrrolo [2,3-b] pyrazine may participate in metal-catalyzed coupling reactions, such as Suzuki coupling, Stille coupling, etc. With the help of such reactions, it can be connected with other organic fragments to construct more complex organic molecules, which is of great significance in drug synthesis, materials science and other fields.

2-Bromo-5H-pyrrolido [2,3-b] pyrazine is an important intermediate in organic synthesis. The common synthesis methods are as follows:
First, pyrrolido [2,3-b] pyrazine is used as the starting material, and bromine atoms are introduced by halogenation reaction. This reaction usually needs to be carried out in a suitable reaction solvent, such as halogenated hydrocarbon solvents such as dichloromethane and chloroform. The commonly used halogenation reagent is N-bromosuccinimide (NBS), and the reaction conditions are relatively mild. During the reaction, NBS will generate bromine free radicals under the action of initiators such as benzoyl peroxide, and then react with pyrrole [2,3-b] pyrazine to generate 2-bromo-5H-pyrrole [2,3-b] pyrazine.
Second, the pyrrole [2,3-b] pyrazine skeleton was simultaneously constructed by cyclization reaction with compounds containing pyrrole and pyrazine structural fragments and bromine atoms were introduced. For example, suitable ortho-aminopyridine derivatives and bromine-containing α-halogenated carbonyl compounds can be selected. Under the catalysis of bases, nucleophilic substitution reactions first occur, and then intra-molecular cyclization occurs to form the target product. Inorganic bases such as potassium carbonate and sodium carbonate can be selected for bases, and polar aprotic solvents such as N, N-dimethylformamide (DMF) and dimethylsulfoxide (DMSO) can be used for reaction solvents.
Third, it is synthesized by coupling reaction catalyzed by transition metals. Halogenated pyrazine derivatives and bromine-containing pyrrole derivatives are used as raw materials, and C-C bond coupling reactions occur under the action of transition metal catalysts such as palladium and nickel. Commonly used palladium catalysts such as tetra (triphenylphosphine) palladium (0) need to be carried out in the presence of appropriate ligands such as tri-tert-butylphosphine to promote the reaction. The reaction solvent can be selected from toluene, dioxane and other organic solvents, and it needs to be protected by inert gas to avoid oxidation of the transition metal catalyst, so as to efficiently synthesize 2-bromo-5H-pyrrolido [2,3-b] pyrazine.

2 - Bromo - 5H - pyrrolo [2,3 - b] pyrazine is a heterocyclic compound containing bromine, which has applications in various fields.
In the field of pharmaceutical research and development, this compound can be used as a key intermediate. Due to its unique chemical structure, it can be combined with other functional groups by organic synthesis to create new compounds with specific biological activities. Medical research often requires the design and synthesis of new molecules to explore drugs with high efficiency and low toxicity. The heterocyclic structure of 2-Bromo-5H-pyrrolo [2,3-b] pyrazine may interact with specific targets in organisms, such as proteins, enzymes, etc., or have potential value in the treatment of certain diseases, such as anti-cancer, antiviral, antibacterial and other drug development.
In the field of materials science, it also has potential applications. Heterocyclic compounds often have unique electrical and optical properties. 2-Bromo-5H-pyrrolo [2,3-b] pyrazine may be modified and applied to the preparation of organic optoelectronic materials. For example, in the fields of organic Light Emitting Diode (OLED) and organic solar cells, such materials are crucial for improving the performance of devices. The bromine atom and heterocyclic system in its structure can adjust the electronic transport and energy level structure of the material, so as to optimize the performance of the material in photoelectric conversion and luminous efficiency.
In the field of chemical synthesis, as an intermediate with a special structure, it can participate in a variety of chemical reactions, such as nucleophilic substitution reactions, coupling reactions, etc. Through these reactions, more complex and diverse organic molecular structures can be constructed, providing new approaches and methods for the development of organic synthetic chemistry, enriching the variety and structural diversity of organic compounds, and promoting the continuous development of organic synthetic chemistry.

Today I have a question, what is the market price of 2 - Bromo - 5H - pyrrolo [2,3 - b] pyrazine. However, the price of the market often changes with time and varies with various circumstances. The price of this compound, whether used in various scientific research or in industrial fields, is determined by the difficulty of preparation, the amount required, and the price of the material.
The difficulty of preparation has a heavy impact. If the method is difficult, the materials used are rare, and both manpower and material resources are expensive, the price will be high. The number of required is also a major factor. If there are many people who ask for it, but there are few people who supply it, the price will rise; if there are few people who ask for it, the supply will exceed the demand, and the price will drop. The price of the material is also determined by its price. If the raw materials for making this thing are easy to obtain and cheap, the price will be flat; if the raw materials are rare, the price will be high.
The situation of the market changes. The policies of merchants and the competition of the same industry can make the price rise and fall. To know the exact price, you can get a more realistic price when you consult the merchants of the chemical industry, the shops of materials, or observe the market conditions and records of transactions. However, this price is also very fixed, and often changes with the passage of time and changes in events.