2-bromo-5-(methylthio)pyrazine

2-Bromo-5- (methylthio) pyrazine is an organic compound with unique chemical properties. Its appearance is often solid, and it has high chemical activity due to the presence of bromine and sulfur-containing groups.
Let's talk about the bromine atom first, which is a halogen element, which gives the compound nucleophilic substitution activity. Under suitable conditions, the bromine atom can be replaced by a variety of nucleophilic reagents, such as hydroxyl (-OH), amino (-NH2O), etc. This property can be used to synthesize organic compounds with more complex structures, such as reacting with nucleophilic alcohols to form ether-bonded derivatives through substitution reactions. This process needs to be carried out in base catalysis and suitable solvents.
Let's talk about methyl sulfide (-SCH), which is a sulfur-containing functional group, which has an impact on the electron cloud distribution of the compound, which in turn affects its reactivity. Methyl sulfide can participate in the oxidation reaction, and under the action of appropriate oxidants, sulfur atoms can be oxidized to sulfoxide (-SOCH
) or sulfone (-SO < CH
) form, thereby changing the polarity and reactivity of the compound.
2 -bromo-5- (methylthio) pyrazine, the conjugated structure of the pyrazine ring gives the compound a certain stability. However, the bromine and methyl sulfide groups on the ring can participate in various reactions, providing a diverse path for organic synthesis. For example, in a metal-catalyzed coupling reaction, bromine atoms can undergo a Suzuki coupling reaction with aryl boronic acid to form a new carbon-carbon bond and expand the conjugate system of the molecule. This reaction requires the participation of palladium catalysts and suitable ligands.
Due to the difference in electronegativity between bromine and sulfur atoms in the molecule, the compound has a certain polarity and has different solubility in organic solvents. Generally speaking, it is soluble in common organic solvents such as dichloromethane, chloroform, N, N-dimethylformamide, etc. This solubility is conducive to the selection of suitable reaction media and methods in the process of organic synthesis and separation and purification.

The synthesis of 2-bromo-5- (methylthio) pyrazine has been known for a long time, and it is composed of several steps.
One method is to use 5- (methylthio) pyrazine-2-amine as the starting material. First, make it with an appropriate amount of brominating reagents, such as liquid bromine or N-bromosuccinimide (NBS), in a suitable solvent, such as dichloromethane, at a low temperature and in the presence of a suitable catalyst, such as benzoyl peroxide. The bromine atom in the brominating reagent can replace the hydrogen atom in the ortho-position of the amine group to obtain 2-bromo-5- (methylthio) pyrazine. This process requires careful temperature control to prevent over-bromination and impurity of the product.
Another method uses 2-chloro-5- (methylthio) pyrazine as raw material. To replace the chlorine atom with a bromine atom, potassium bromide and an appropriate phase transfer catalyst, such as tetrabutyl ammonium bromide, are often used in a polar solvent, such as N, N-dimethylformamide (DMF). The phase transfer catalyst can help ions transfer between the two phases, accelerating the reaction rate. The chlorine atom is replaced by a bromine atom through a nucleophilic substitution reaction, and the final product is obtained.
Furthermore, methylthio can be introduced first from the parent of pyrazine. 5 - (methylthio) pyrazine is obtained by reacting pyrazine with sodium methylthiol under appropriate conditions, and thiol ions attack the pyrazine ring. Subsequently, according to the above bromination method, bromine atoms are introduced to prepare 2-bromo-5 - (methylthio) pyrazine.
The various synthesis methods have their own advantages and disadvantages, and they need to be carefully selected according to the availability of raw materials, the difficulty of reaction conditions, and the purity requirements of the product.

2-Bromo-5- (methylthio) pyrazine is a class of organic compounds. It has a wide range of uses and is often a key intermediate in the synthesis of many drugs in the field of medicinal chemistry. The structure of Geinpyrazine has unique chemical properties and biological activities. By introducing bromine atoms and methylthio groups, the physical, chemical and biological properties of compounds can be precisely regulated to meet the design requirements of specific drug molecules.
In the field of pesticide chemistry, this compound also has important functions. Through its structural modification and derivatization, pesticide varieties with high insecticidal, bactericidal or herbicidal activities can be created. The presence of bromine atoms and methylthio groups can affect the interaction between compounds and specific receptors or enzymes in target organisms, enhancing the biological activity and selectivity of pesticides.
In addition, in the field of materials science, 2-bromo-5- (methylthio) pyrazine may be used as a basic unit for the construction of new organic functional materials. Through its reaction with other organic or inorganic components, it is expected to prepare materials with special optical, electrical or magnetic properties, which can be used in many advanced technologies such as Light Emitting Diodes and sensors. In short, due to the unique structure of this compound, it has shown potential and important application value in many fields.

I have not heard the exact price of 2 - bromo - 5 - (methylthio) pyrazine in the market. However, if you want to check its price, you can explore it through various channels.
First, a professional website for trading chemical raw materials, such platforms often gather suppliers, and their prices may vary depending on quantity, quality, and supply conditions. All merchants list quotations, which can be compared to obtain an approximate price range.
Second, ask the distributor of chemical products. He is often involved in the sale of this product, knows a lot about the market conditions, and can tell the current price range according to the current supply and demand, origin, and purity.
Third, participate in exhibitions and seminars in the chemical industry. Here, you can communicate directly with various industry players, obtain the price dynamics of this product, and hear the new news of the industry, which helps to know the market situation in detail.
Although the price is not confirmed, following this path may indicate the approximate price range of 2-bromo-5- (methylthio) pyrazine in the market.

2 - bromo - 5 - (methylthio) pyrazine is a chemical substance. Its storage conditions are crucial, which is related to the stability and quality of this substance.
To properly store this substance, the first thing to do is to place it in a cool place. In a cool place, the temperature is relatively constant, so that it will not cause chemical reactions and cause it to deteriorate due to excessive temperature. High temperature can often promote the enhancement of molecular activity, accelerate the process of chemical reactions, and destroy the chemical structure of the substance.
Keep it dry. Moisture easily reacts with many chemicals, and 2 - bromo - 5 - (methylthio) pyrazine may also be affected by it. Moisture can cause reactions such as hydrolysis and change its chemical composition. Therefore, in the storage place, when avoiding moisture, a desiccant can be placed near the storage container to absorb excess water vapor.
Furthermore, it should be stored in a well-ventilated place. Good ventilation can avoid local accumulation of volatile gas and reduce the risk of explosion or poisoning. If there is no air circulation in the storage space, the volatile gas of the substance may accumulate, and it may be dangerous in case of open flame or static electricity.
Storage containers should not be ignored. Use well-sealed containers to prevent the intrusion of impurities such as air and moisture. And the container material should not react with 2-bromo-5- (methylthio) pyrazine to avoid contaminants. Glass containers or specific plastic containers are often suitable, depending on the specific properties of the substance.
During storage, it should also be kept away from fire sources and oxidants. Fire sources can cause combustion, and oxidants can come into contact with them, or cause severe oxidation reactions, which can endanger safety.
In general, 2-bromo-5 - (methylthio) pyrazine should be stored in a cool, dry, well-ventilated place, sealed in a suitable container, and away from fire sources and oxidants, so as to ensure its stable properties and quality.