2-Amino-6-Chloropyrazine

2-Amino-6-chloropyrazine is useful in various fields. In the field of medicinal chemistry, it is often the key raw material for the synthesis of various drugs. It covers its unique chemical structure, enabling it to combine with many targets in the body, and then exert pharmacological activity. Taking antibacterial drugs as an example, drugs made from this base may use their structural properties to interfere with bacterial metabolic pathways and achieve bacteriostatic or bactericidal effects.
In materials science, 2-amino-6-chloropyrazine also makes a difference. It can be used to prepare special functional materials, because it has certain reactivity and can participate in polymerization reactions, etc., thereby changing the physical and chemical properties of materials, such as enhancing the stability and conductivity of materials, so that materials can be used in electronic devices, optical materials and other fields.
Furthermore, in the field of organic synthetic chemistry, it is a commonly used intermediate. Chemists can use it to carry out a series of chemical reactions to construct more complex organic molecular structures. Because it contains functional groups such as nitrogen and chlorine, it can derive many organic compounds with different properties and functions through substitution, addition and other reactions, which contribute to the development of organic synthetic chemistry and promote the creation and research of new compounds.

2-Amino-6-chloropyrazine is one of the organic compounds. Its physical properties are worth a detailed investigation.
Looking at its appearance, it often shows a crystalline powder like white to light yellow, which is the characterization of the eye. As for the color, the white to light yellow state is a significant feature of its appearance and can be distinguished by the naked eye.
When it comes to the melting point, it is between 152-156 ° C. The melting point is the critical temperature at which a substance changes from a solid state to a liquid state. This temperature range is an important physical property of 2-amino-6-chloropyrazine. In this temperature range, the balance of forces between molecules changes, causing the state of the substance to change.
Solubility is also a key physical property. Its solubility in water is limited, but it can be dissolved in organic solvents such as dimethyl sulfoxide (DMSO), N, N-dimethylformamide (DMF), etc. This difference in solubility is due to the difference between the molecular structure and the interaction between solvent molecules. Water is a polar solvent, and the structure of 2-amino-6-chloropyrazine makes it weakly interact with water molecules; while the polarity and molecular structure of organic solvents such as DMSO and DMF enable it to form a strong interaction with 2-amino-6-chloropyrazine, so it can be dissolved.
In addition, 2-amino-6-chloropyrazine has a certain stability. Under normal temperature and pressure and dry environment, it can maintain a relatively stable state. In case of extreme conditions such as strong acid, strong alkali or high temperature, its structure may change and cause chemical reactions. This is also the main point related to its physical properties.

The synthesis method of 2-amino-6-chloropyrazine is described in ancient books. First, 6-chloropyrazine is prepared by chlorination with pyrazine as the starting material, and then it is reacted with ammonia to obtain 2-amino-6-chloropyrazine. In this reaction, the chlorination step needs to select suitable chlorination reagents, such as thionyl chloride, phosphorus oxychloride, etc., and react in a suitable temperature and solvent. In the ammonolysis step, the reaction conditions, such as temperature, pressure, and ammonia dosage, need to be controlled to increase the yield of the product.
Second, a compound containing a specific substituent is used as the starting material and prepared through a multi-step reaction. For example, a compound containing nitrogen and chlorine with suitable active groups is first cyclized to construct a pyrazine ring, and then modified and converted to obtain the target product 2-amino-6-chloropyrazine. In this approach, the cyclization reaction is the key, and appropriate reaction conditions and catalysts need to be selected to make the reaction proceed in the direction of generating pyrazine rings. Subsequent modification and conversion steps also need to be carefully regulated to achieve the purity and yield requirements of the target product.
Third, other heterocyclic compounds are also used as starting materials, and through a series of reactions such as ring opening, rearrangement, and cyclization, 2-amino-6-chloropyrazine is finally obtained. Although these methods are complicated in steps, under specific circumstances, they may have unique advantages, such as avoiding some uncontrollable reaction steps or improving the selectivity of the product.
Synthetic methods have their own advantages and disadvantages. According to actual needs, consider the availability of raw materials, cost, difficulty of reaction and yield, and choose carefully to obtain satisfactory synthetic results.

At present, I want to know the price range of 2-amino-6-chloropyrazine in the market, but the market situation is complicated, and the price often changes due to various factors. In the past, the price fluctuation of this chemical was determined by the supply and demand of raw materials, the difficulty of preparation, and the amount of market demand.
If the raw materials are abundant and easy to produce, and the supply is abundant, the price may become stable and low. However, if the raw materials are scarce, the collection is difficult, and the production method is complicated, many reagents and equipment are required, resulting in rising costs and high prices. Market demand is also the key. If many industries compete for this product, the demand is strong and the supply is tight, and the price will rise; if the demand is weak, the supply is excessive, and the price may drop.
According to past transactions and industry rumors, the price of 2-amino-6-chloropyrazine ranges from tens to hundreds of yuan per gram. When purchasing on a large scale, due to the considerable quantity, the supplier may give a discount, and the unit price may drop. And different quality levels have different prices. High purity is expensive, and ordinary purity is slightly less expensive. However, this is only a rough estimate. Today's exact price still needs to be consulted with various chemical raw material suppliers to obtain an accurate figure.

2-Amino-6-chloropyrazine is an important organic compound, which is widely used in many fields such as medicine, pesticides and materials. Its manufacturers are numerous and distributed all over the world.
In China, there are many manufacturers involved in the production of 2-amino-6-chloropyrazine. For example, there are manufacturers in Zhejiang, with advanced technology and sophisticated equipment, who work hard on the production process and strictly control the quality of their products. The quality of the 2-amino-6-chloropyrazine produced is high, and it has a good reputation in the market and is favored by customers. There are also enterprises in Jiangsu that continue to increase investment in research and development, actively innovate, and optimize production processes to enhance product competitiveness. Their products are not only supplied to the domestic market, but also exported overseas.
There are also manufacturers specializing in the production of 2-amino-6-chloropyrazine in overseas, Europe, America and other places. For example, some manufacturers in the United States, relying on strong scientific research strength and mature industrial system, have unique advantages in product purity and performance, and occupy a place in the international high-end market. Some European manufacturers are good at fine chemicals. The 2-amino-6-chloropyrazine they produce is widely used in specific fields and is known for its high quality and stable supply.
To sum up, the manufacturers of 2-amino-6-chloropyrazine are all over the world, and different manufacturers have their own strengths and weaknesses. With their own characteristics and advantages, they meet the diverse needs of the market.