2-Amino-5-Bromo-3-Cyanopyrazine

2-% hydroxy-5-sulfonic acid-3-aminopyridine, this substance has a wide range of uses. In the field of medicine, it is a key intermediate and can help synthesize many specific drugs. For example, in the development of drugs for the treatment of cardiovascular diseases, it participates in the construction of drug activity structures, which is of great significance for regulating cardiovascular function; in the development of antibacterial drugs, with its unique chemical structure, it imparts stronger antibacterial activity and specificity to drugs, which can effectively inhibit the growth and reproduction of specific bacteria.
In the field of materials science, it can be used to prepare functional materials. Such as the preparation of materials with special optical properties, after special processing, the material can produce unique absorption and emission of specific wavelengths of light, which can be used in optical sensors, optical storage devices, etc.; It can also be used to improve the properties of polymer materials, enhance their stability, mechanical properties, etc., improve the comprehensive quality of materials, and broaden the application range.
In the dye industry, as an important raw material, it can synthesize dyes with bright colors and high stability. Due to its structural characteristics, it can make dyes better adhere to fabrics and other substrates, and it is not easy to fade after sun exposure, washing, etc., to meet the needs of high-quality dyes in textile, printing and dyeing industries, and is widely used in various textile dyeing processes. In conclusion, 2-% hydroxy-5-sulfonic acid-3-aminopyridine plays a key role in many fields such as medicine, materials, and dyes due to its unique chemical structure and properties, and effectively promotes the development and progress of related industries.

2-% hydroxy-5-sulfonic acid-3-aminopyridine is a special organic compound with the following physical properties:
- ** Appearance properties **: Under normal conditions, it is mostly in the state of white to light yellow crystalline powder with fine texture. This form is convenient for storage, transportation and subsequent processing. Because it is powdery, when mixed with other substances, it can be more evenly dispersed, which is conducive to the full progress of chemical reactions.
- ** Melting point Boiling point **: The melting point is in a specific temperature range, and the specific value will fluctuate due to purity and other factors, roughly around [X] ° C. The melting point is relatively high, indicating that the intermolecular force is strong and the structure is relatively stable. The boiling point is around [Y] ° C. The higher boiling point makes it stable in solid or liquid state under conventional conditions, and it is not easy to volatilize. It will only change the phase state under specific conditions such as heating.
- ** Solubility **: It shows a certain solubility in water and can be partially dissolved to form a uniform solution. In organic solvents such as ethanol and acetone, the solubility is also different. The solubility in ethanol is moderate, and the solubility in acetone is relatively small. This solubility characteristic provides possibilities for its application in different chemical systems. For example, in solution reactions, suitable solvents can be selected according to their solubility to promote the smooth progress of the reaction.
- ** Density **: The density is about [Z] g/cm ³, which is similar to the density of common organic compounds. This density value determines its distribution when mixed with other substances, and has a certain impact on the material ratio and the stability of the reaction system in the relevant chemical production process.
- ** Odor and Taste **: The smell is weak and there is no special irritating smell. In terms of taste, it cannot be tasted because it is a chemical substance, but it is inferred from the structure that it does not have obvious special taste. This feature makes it not uncomfortable to the operating environment and human body due to strong odor during use, which is conducive to practical application.

To prepare 2-amino-5-bromo-3-nitropyridine, the following methods can be used:
First, start with pyridine, and introduce nitro groups into the pyridine ring by nitrification. Due to the electron cloud density distribution of the pyridine ring, the nitro group is mostly in the 3-position. Then the step of bromination, under appropriate conditions, the bromine atom can enter the 5-position. Finally, through reduction reaction, the nitro group is converted into an amino group to obtain the target product. However, it is necessary to pay attention to the control of the reaction conditions in each step to prevent side reactions, such as excessive nitrification and position selection deviation of bromination. < Br >
Second, a suitable pyridine derivative can be found as the starting material, and this derivative already has some of the required substituents. After a reasonable reaction, the remaining substituents are gradually introduced. For example, a derivative containing an appropriate substituent can activate a specific position of the pyridine ring, so that the subsequent reaction can proceed in the desired direction, so as to increase the selectivity of the reaction, reduce the possibility of side reactions, and reduce the difficulty of separation and purification.
Third, a metal-catalyzed coupling reaction is used. First, a pyridine derivative containing a halogen atom (such as bromine) is prepared, and then it is mediated by a metal catalyst (such as a palladium catalyst) to couple with a reagent containing an amino group and a nitro group. This approach can precisely construct carbon-nitrogen bonds, carbon-carbon bonds, etc., which are commonly used in the synthesis of complex pyridine derivatives. However, the price of metal catalysts may be high, and the reaction conditions may be harsh, so attention should be paid to the recovery of catalysts and the optimization of reaction conditions.
Fourth, the rearrangement reaction strategy is used. The pyridine precursor with a specific structure is selected, and the pyridine derivative with the target substitution mode is obtained through the rearrangement reaction. The rearrangement reaction can realize the migration and transformation of substituents under relatively mild conditions, which has unique advantages. However, it is necessary to know the mechanism of the rearrangement reaction, precisely design the precursor structure, and guide the reaction in the desired direction. < Br >
There are various methods for preparing 2-amino-5-bromo-3-nitropyridine, each with its own advantages and disadvantages. In actual synthesis, the optimal synthesis path should be selected according to factors such as raw material availability, cost, reaction difficulty and product purity.

In today's market, the price of 2-amino-5-bromo-3-aminopyridine is quite influenced by various factors.
The quality of its raw materials is greatly related. The manufacture of this compound requires specific raw materials. If its source is narrow and the public is sought, the price will increase. For example, if the origin of the base material depends on the occasional catastrophe, or the government changes, the production and transportation of it will be hindered, and the cost of 2-amino-5-bromo-3-aminopyridine will increase, and the price will also rise.
Furthermore, the clumsy craftsmanship also affects its price. Sophisticated methods can reduce consumption and increase production, and reduce its cost. If the new technology is created, it can be efficiently aggregated, and the material is saved, the price of the product may be competitive in the city. On the contrary, if the craftsmanship is old-fashioned, the consumption is huge and the production is small, the price will be difficult to lower.
The supply and demand of the city is particularly critical. When this product is in demand in the pharmaceutical and chemical industries, but the supply is insufficient, the price will rise. If a pharmaceutical company develops a new drug and takes it as a material, the demand will surge, but the producer does not respond quickly, and the price will rise. If the market supply is too profitable, but there are few applicants, the business will sell it quickly, or cut the price to compete for the market.
In addition, changes in the world situation also have an impact. Such as the establishment of barriers to trade, the increase or decrease of taxes, can cause changes in its price. The two countries are at odds, and trade restrictions are frequent. The transmission of this product is blocked, and its price may change at home and abroad. If the tax increases, the price of the business will increase, and the price will also rise accordingly.
In summary, the price of 2-amino-5-bromo-3-aminopyridine in the market is not determined uniformly. Raw materials, craftsmanship, supply and demand, and the world situation are all intertwined, making its price constant and unpredictable.

The storage conditions of 2-% hydroxy-5-sulfonic acid-3-sulfobenzaldehyde are crucial to whether this substance can maintain its characteristics and quality for a long time. According to the principles of storage and protection of various substances involved in "Tiangong Kaiwu", the following numbers should be extended to this substance.
First heavy drying. Moisture is the cause of deterioration of various substances, and 2-% hydroxy-5-sulfonic acid-3-sulfobenzaldehyde encounters formaldehyde water, or causes hydrolysis and isochemical change, which damages its structure and properties. Therefore, it is best to choose a dry place and avoid it in a damp place such as a cellar. A desiccant can be placed in the reservoir, such as quicklime, anhydrous calcium chloride, etc., to absorb the surrounding water vapor and keep it dry.
The second time is low temperature. If the temperature is too high, the reaction rate of the substance is often accelerated, causing its decomposition and oxidation. 2-% hydroxy-5-sulfonic acid-3-sulfobenzaldehyde should be stored in a cool and low temperature place, such as deep in the cellar, or in summer with the help of an ice cellar. However, it is also necessary to prevent its undercooling from freezing, which affects the access and quality. Moderate low temperature is appropriate.
and need to be protected from light. Under light, many organic compounds are prone to photochemical reactions and cause structural changes. 2-% hydroxy-5-sulfonic acid-3-sulfobenzaldehyde or the same, so it should be stored in a dark bottle, such as a brown glass bottle, which blocks light from penetrating, or hidden in a dark room to avoid direct light.
In addition, its storage place should be away from fire, heat sources and strong oxidants. This substance may have certain chemical activity and may react violently in case of fire, heat or strong oxidants, causing the risk of explosion and damaging itself. And it is separated from other substances to prevent mutual pollution and reaction.
In summary, 2-% hydroxy-5-sulfonic acid-3-sulfobenzaldehyde should be stored in a dry, cool, dark place, and isolated from dangerous substances, so as to maintain its stability and prepare for emergencies.