2-Amino-3-bromopyrazine

2-Amino-3-bromopyrazine is one of the organic compounds. Its physical properties are quite important and are related to many chemical applications.
Looking at its appearance, it often takes the form of a white to pale yellow crystalline powder, which is common in most chemical experiments and industrial production scenes. Its color and morphology can be the key clues for preliminary identification of this substance.
When it comes to the melting point, it is about 134-138 ° C. The melting point is the inherent physical property of the substance, by which its purity can be identified. If the melting point of the sample is consistent with this range and the melting range is narrow, the purity is quite high; conversely, if it deviates from this range or the melting range is wide, it may contain impurities.
Solubility is also an important physical property. 2-Amino-3-bromopyrazine is slightly soluble in water, but it exhibits good solubility in common organic solvents such as ethanol and dichloromethane. This property is of great significance in the extraction, separation and other steps in organic synthesis. In ethanol, molecules and ethanol interact with hydrogen bonds to achieve dissolution; in dichloromethane, due to the matching of the forces between the two molecules, they can also be well miscible.
In addition, the compound has certain stability and can maintain its own chemical structure under conventional conditions. However, under extreme conditions such as high temperature and strong acid and alkali, its structure may change.
In summary, the physical properties of 2-amino-3-bromopyrazine, such as appearance, melting point, solubility and stability, are of great value in chemical research, organic synthesis and related industrial fields, providing a key basis for its application and treatment.

2-Amino-3-bromopyrazine is one of the organic compounds. Its chemical properties are particularly important and have applications in many fields.
This compound has certain reactivity. Due to the existence of amino and bromine atoms, it can initiate a variety of chemical reactions. Amino groups are nucleophilic and can participate in nucleophilic substitution reactions. For example, when they meet halogenated hydrocarbons, the nitrogen atom of the amino group can attack the carbon atom of the halogenated hydrocarbon, and the halogen atom leaves, forming a new carbon-nitrogen bond to obtain a replacement product.
Furthermore, bromine atoms are also active and can undergo nucleophilic substitution. In the case of nucleophiles, bromine can be replaced. For example, under basic conditions, hydroxyl and other nucleophiles can replace bromine atoms to produce derivatives containing hydroxyl groups.
2-Amino-3-bromopyrazine can also participate in the cyclization reaction. In its molecular structure, the pyrazine ring interacts with the amino group and the bromine atom. Under appropriate conditions, the amino group and other parts in the molecule are reacted to form a new cyclic structure, which may increase its structural complexity and stability.
In the aspect of redox reaction, the amino group may be oxidized, causing the valence state of the nitrogen atom to change, and the corresponding oxidation product is formed. The pyrazine ring may also change the distribution of electron clouds on the ring due to different reaction conditions, or be reduced, resulting in different structures and properties.
In addition, the physical properties of 2-amino-3-bromopyrazine also affect its chemical behavior. Its solubility is different in different solvents, which plays a role in the process and products of the reaction in which it participates. In organic solvents, its molecules interact with solvent molecules, or change the reaction activity and selectivity.
In summary, 2-amino-3-bromopyrazine is chemically active due to the characteristics of amino and bromine atoms and pyrazine rings. It can participate in a variety of reactions and has important value in organic synthesis and other fields.

2-Amino-3-bromopyrazine is also an important intermediate in organic synthesis. Its common synthesis methods are as follows:
First, pyrazine is used as the starting material. Pyrazine has a conjugated system and has unique chemical properties. First, under specific reaction conditions, pyrazine is halogenated with suitable halogenating reagents, such as bromine or bromine-containing compounds, and bromine atoms are introduced into its ring to obtain 3-bromopyrazine. After nitration reaction, nitro is introduced at a suitable position, and then by reduction means, such as iron powder, zinc powder and other gold belong to acidic medium, or by catalytic hydrogenation, the nitro group is converted into amino group, and then 2-amino-3-bromopyrazine is obtained. This route step is relatively clear, but the reaction conditions of each step need to be carefully regulated. The position selectivity of bromination during halogenation and the regioselectivity during nitrification are key considerations.
Second, the pyrazine ring is constructed with compounds containing nitrogen and bromine. If a nitrogen-containing heterocyclic precursor is selected and reacted with a bromine-containing electrophilic or nucleophilic reagent in the presence of a suitable catalyst, it is cyclized to form a pyrazine ring, and amino and bromine atoms are introduced at the same time. This approach requires careful design of the precursor structure and reaction conditions to make the cyclization reaction efficient and obtain the target product. For example, some nitrogen-containing dicarbonyl compounds and bromine-containing amine compounds, catalyzed by basic catalysts, can be cyclized and condensed within molecules to construct pyrazine rings and introduce corresponding substituents. This method can construct the target molecule in one or several steps, which can improve the synthesis efficiency, but requires strict raw material selection and reaction conditions.
Third, bromination is carried out using aminopyrazine as raw material. Aminopyrazine is first protected by a protective group to prevent the amino group from being affected during bromination. Commonly used protective groups such as tert-butoxycarbonyl (BOC), benzyloxycarbonyl (Cbz), etc. The protected aminopyrazine is then reacted with a brominating reagent to introduce bromine atoms at a specific position, and finally the protective group is removed to obtain 2-amino-3-bromopyrazine. This method can better control the bromination position by protecting the amino group first, reduce the occurrence of side reactions, and improve the purity and yield of the product. However, the steps of protection and deprotection are increased, resulting in an increase in the synthesis route.
All these synthetic methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively weigh many factors such as raw material availability, cost, target product purity and yield to choose the best synthetic path.

2-Amino-3-bromopyrazine is used in various fields such as medicine and materials.
In the field of medicine, it is often a key intermediate for the synthesis of various drugs. Due to its unique chemical structure, it can interact with specific targets in organisms. It can be connected to other functional groups through specific chemical reactions to construct compounds with specific pharmacological activities. For example, for the development of antibacterial drugs, its structure can help the drug to precisely act on the specific metabolic pathway of bacteria, interfere with the normal physiological activities of bacteria, and achieve antibacterial effect; when developing anticancer drugs, it can use its structural characteristics to design drugs that can target specific proteins or signaling pathways of tumor cells to inhibit the proliferation and spread of tumor cells.
In the field of materials, 2-amino-3-bromopyrazine also has outstanding performance. First, in the preparation of organic optoelectronic materials, it can be used as a basic structural unit. Due to its structure endowing the material with specific electrical and optical properties, introducing it into polymer or small molecule materials can adjust the energy level structure of the material, improve the charge transport performance, and improve the luminous efficiency of the material. It is expected to be applied to optoelectronic devices such as organic Light Emitting Diodes (OLEDs), making the display screen thinner, more energy-efficient and with higher resolution. Second, in the synthesis of functional polymer materials, it can be used as a cross-linking agent or modifier. By chemically reacting with polymer chains, the physical and chemical properties of polymer materials are changed, such as enhancing the mechanical strength of materials and improving thermal stability, making materials widely used in aerospace, automobile manufacturing and other fields that require strict material properties.
In summary, 2-amino-3-bromopyrazine has shown important application value in the fields of medicine and materials, providing key support for the development of many fields.

Today, there are inquiries about the market price of 2-amino-3-bromopyrazine. This 2-amino-3-bromopyrazine is an organic compound, which is widely used in medicine, pesticides, materials science and other fields. Its market price is difficult to hide, due to many factors.
First, the cost of raw materials has a great impact. If the price of raw materials used to synthesize 2-amino-3-bromopyrazine fluctuates, the cost of 2-amino-3-bromopyrazine will also change, which in turn affects the selling price. If the raw materials are scarce, or the production process of raw materials changes, resulting in an increase in the cost of this compound, the price of this compound will increase.
Second, the simplicity of the production process is also the key. If the production process of 2-amino-3-bromopyrazine is complicated, requires multiple processes, and requires strict reaction conditions, such as precise temperature and pressure control, and high equipment requirements, the production cost will increase, and the market price will also rise. And if a simple and efficient new process comes out, the cost may be reduced, and the price is expected to be lowered.
Third, the market supply and demand relationship is the main factor that determines the price. If the market demand for 2-amino-3-bromopyrazine is strong and the supply is limited, the price will rise; conversely, if there is an excess supply and insufficient demand, the price will decline. For example, if there is a new research and development in the pharmaceutical field, the demand for this compound will increase sharply, and the manufacturer fails to expand production capacity in time, the price will rise.
Fourth, product quality and purity also affect the price. High-purity 2-amino-3-bromopyrazine, because it can meet the needs of high-end applications, such as scenes with extremely high impurity requirements in pharmaceutical research and development, its price is often higher than that of lower purity.
In summary, the market price of 2-amino-3-bromopyrazine is not fixed and often changes due to factors such as raw material cost, production process, supply and demand relationship, and product quality. To know the exact price, it is recommended to consult the relevant chemical product suppliers, distributors, or refer to the latest quotations of the chemical product trading platform to obtain more accurate price information.